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Inflammation-related proteins in blood after dermal exposure to some common chemicals depend on the skin barrier gene filaggrin - a human experimental study

Liljedahl, Emelie Rietz LU ; Gliga, Anda ; de Paula, Helena Korres LU ; Engfeldt, Malin LU ; Julander, Anneli ; Lidén, Carola ; Lindh, Christian LU orcid and Broberg, Karin LU orcid (2024) In Environmental Toxicology and Pharmacology 105.
Abstract

Filaggrin (FLG), a skin barrier protein, is associated with higher dermal uptake of some chemicals in carriers of loss-of-function (null) mutations. This study investigates FLG mutations and systemic effects following dermal exposure to chemicals. Individuals (n = 23 FLG null, n = 31 FLG wt) were simultaneously exposed to pyrimethanil, pyrene, oxybenzone, and nickel ions for 4 h. Pre- and post-exposure, 25-hydroxyvitamin D3 (25(OH)D3, LC-MS/MS) and 92 inflammation-related proteins (proximity-extension assay) were measured. FLG null carriers exhibited significantly higher 25(OH)D3 concentrations than wt carriers, both pre- and post-exposure. Eleven proteins differed in abundance post- vs pre-exposure among FLG null carriers, and 22... (More)

Filaggrin (FLG), a skin barrier protein, is associated with higher dermal uptake of some chemicals in carriers of loss-of-function (null) mutations. This study investigates FLG mutations and systemic effects following dermal exposure to chemicals. Individuals (n = 23 FLG null, n = 31 FLG wt) were simultaneously exposed to pyrimethanil, pyrene, oxybenzone, and nickel ions for 4 h. Pre- and post-exposure, 25-hydroxyvitamin D3 (25(OH)D3, LC-MS/MS) and 92 inflammation-related proteins (proximity-extension assay) were measured. FLG null carriers exhibited significantly higher 25(OH)D3 concentrations than wt carriers, both pre- and post-exposure. Eleven proteins differed in abundance post- vs pre-exposure among FLG null carriers, and 22 proteins among wt carriers (three proteins overlapped). Twelve proteins showed median differences (post- vs pre-exposure) between FLG null and wt carriers. Overall, FLG null carriers showed an increase, while FLG wt carriers showed a decrease in inflammation-related proteins. These findings suggest FLG-dependent differences in susceptibility to systemic effects following simultaneous dermal chemical exposure.

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author
; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Environmental exposure, Genetic susceptibility, Inflammation, Occupational exposure, Skin absorption, Skin barrier, Vitamin D
in
Environmental Toxicology and Pharmacology
volume
105
article number
104346
publisher
Elsevier
external identifiers
  • pmid:38135200
  • scopus:85180557860
ISSN
1382-6689
DOI
10.1016/j.etap.2023.104346
language
English
LU publication?
yes
id
1cec889e-69b6-4d84-b761-45e9d21a6d8d
date added to LUP
2024-02-06 15:09:57
date last changed
2024-04-23 16:04:34
@article{1cec889e-69b6-4d84-b761-45e9d21a6d8d,
  abstract     = {{<p>Filaggrin (FLG), a skin barrier protein, is associated with higher dermal uptake of some chemicals in carriers of loss-of-function (null) mutations. This study investigates FLG mutations and systemic effects following dermal exposure to chemicals. Individuals (n = 23 FLG null, n = 31 FLG wt) were simultaneously exposed to pyrimethanil, pyrene, oxybenzone, and nickel ions for 4 h. Pre- and post-exposure, 25-hydroxyvitamin D3 (25(OH)D3, LC-MS/MS) and 92 inflammation-related proteins (proximity-extension assay) were measured. FLG null carriers exhibited significantly higher 25(OH)D3 concentrations than wt carriers, both pre- and post-exposure. Eleven proteins differed in abundance post- vs pre-exposure among FLG null carriers, and 22 proteins among wt carriers (three proteins overlapped). Twelve proteins showed median differences (post- vs pre-exposure) between FLG null and wt carriers. Overall, FLG null carriers showed an increase, while FLG wt carriers showed a decrease in inflammation-related proteins. These findings suggest FLG-dependent differences in susceptibility to systemic effects following simultaneous dermal chemical exposure.</p>}},
  author       = {{Liljedahl, Emelie Rietz and Gliga, Anda and de Paula, Helena Korres and Engfeldt, Malin and Julander, Anneli and Lidén, Carola and Lindh, Christian and Broberg, Karin}},
  issn         = {{1382-6689}},
  keywords     = {{Environmental exposure; Genetic susceptibility; Inflammation; Occupational exposure; Skin absorption; Skin barrier; Vitamin D}},
  language     = {{eng}},
  publisher    = {{Elsevier}},
  series       = {{Environmental Toxicology and Pharmacology}},
  title        = {{Inflammation-related proteins in blood after dermal exposure to some common chemicals depend on the skin barrier gene filaggrin - a human experimental study}},
  url          = {{http://dx.doi.org/10.1016/j.etap.2023.104346}},
  doi          = {{10.1016/j.etap.2023.104346}},
  volume       = {{105}},
  year         = {{2024}},
}