Inflammation-related proteins in blood after dermal exposure to some common chemicals depend on the skin barrier gene filaggrin - a human experimental study
(2024) In Environmental Toxicology and Pharmacology 105.- Abstract
Filaggrin (FLG), a skin barrier protein, is associated with higher dermal uptake of some chemicals in carriers of loss-of-function (null) mutations. This study investigates FLG mutations and systemic effects following dermal exposure to chemicals. Individuals (n = 23 FLG null, n = 31 FLG wt) were simultaneously exposed to pyrimethanil, pyrene, oxybenzone, and nickel ions for 4 h. Pre- and post-exposure, 25-hydroxyvitamin D3 (25(OH)D3, LC-MS/MS) and 92 inflammation-related proteins (proximity-extension assay) were measured. FLG null carriers exhibited significantly higher 25(OH)D3 concentrations than wt carriers, both pre- and post-exposure. Eleven proteins differed in abundance post- vs pre-exposure among FLG null carriers, and 22... (More)
Filaggrin (FLG), a skin barrier protein, is associated with higher dermal uptake of some chemicals in carriers of loss-of-function (null) mutations. This study investigates FLG mutations and systemic effects following dermal exposure to chemicals. Individuals (n = 23 FLG null, n = 31 FLG wt) were simultaneously exposed to pyrimethanil, pyrene, oxybenzone, and nickel ions for 4 h. Pre- and post-exposure, 25-hydroxyvitamin D3 (25(OH)D3, LC-MS/MS) and 92 inflammation-related proteins (proximity-extension assay) were measured. FLG null carriers exhibited significantly higher 25(OH)D3 concentrations than wt carriers, both pre- and post-exposure. Eleven proteins differed in abundance post- vs pre-exposure among FLG null carriers, and 22 proteins among wt carriers (three proteins overlapped). Twelve proteins showed median differences (post- vs pre-exposure) between FLG null and wt carriers. Overall, FLG null carriers showed an increase, while FLG wt carriers showed a decrease in inflammation-related proteins. These findings suggest FLG-dependent differences in susceptibility to systemic effects following simultaneous dermal chemical exposure.
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- author
- Liljedahl, Emelie Rietz LU ; Gliga, Anda ; de Paula, Helena Korres LU ; Engfeldt, Malin LU ; Julander, Anneli ; Lidén, Carola ; Lindh, Christian LU and Broberg, Karin LU
- organization
-
- Division of Occupational and Environmental Medicine, Lund University
- Epidemiology (research group)
- Applied Mass Spectrometry in Environmental Medicine (research group)
- Genetic Occupational and Environmental Medicine (research group)
- Metalund
- Occupational and Environmental Dermatology (research group)
- EpiHealth: Epidemiology for Health
- LUCC: Lund University Cancer Centre
- publishing date
- 2024
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Environmental exposure, Genetic susceptibility, Inflammation, Occupational exposure, Skin absorption, Skin barrier, Vitamin D
- in
- Environmental Toxicology and Pharmacology
- volume
- 105
- article number
- 104346
- publisher
- Elsevier
- external identifiers
-
- scopus:85180557860
- pmid:38135200
- ISSN
- 1382-6689
- DOI
- 10.1016/j.etap.2023.104346
- language
- English
- LU publication?
- yes
- id
- 1cec889e-69b6-4d84-b761-45e9d21a6d8d
- date added to LUP
- 2024-02-06 15:09:57
- date last changed
- 2024-06-18 21:04:54
@article{1cec889e-69b6-4d84-b761-45e9d21a6d8d, abstract = {{<p>Filaggrin (FLG), a skin barrier protein, is associated with higher dermal uptake of some chemicals in carriers of loss-of-function (null) mutations. This study investigates FLG mutations and systemic effects following dermal exposure to chemicals. Individuals (n = 23 FLG null, n = 31 FLG wt) were simultaneously exposed to pyrimethanil, pyrene, oxybenzone, and nickel ions for 4 h. Pre- and post-exposure, 25-hydroxyvitamin D3 (25(OH)D3, LC-MS/MS) and 92 inflammation-related proteins (proximity-extension assay) were measured. FLG null carriers exhibited significantly higher 25(OH)D3 concentrations than wt carriers, both pre- and post-exposure. Eleven proteins differed in abundance post- vs pre-exposure among FLG null carriers, and 22 proteins among wt carriers (three proteins overlapped). Twelve proteins showed median differences (post- vs pre-exposure) between FLG null and wt carriers. Overall, FLG null carriers showed an increase, while FLG wt carriers showed a decrease in inflammation-related proteins. These findings suggest FLG-dependent differences in susceptibility to systemic effects following simultaneous dermal chemical exposure.</p>}}, author = {{Liljedahl, Emelie Rietz and Gliga, Anda and de Paula, Helena Korres and Engfeldt, Malin and Julander, Anneli and Lidén, Carola and Lindh, Christian and Broberg, Karin}}, issn = {{1382-6689}}, keywords = {{Environmental exposure; Genetic susceptibility; Inflammation; Occupational exposure; Skin absorption; Skin barrier; Vitamin D}}, language = {{eng}}, publisher = {{Elsevier}}, series = {{Environmental Toxicology and Pharmacology}}, title = {{Inflammation-related proteins in blood after dermal exposure to some common chemicals depend on the skin barrier gene filaggrin - a human experimental study}}, url = {{http://dx.doi.org/10.1016/j.etap.2023.104346}}, doi = {{10.1016/j.etap.2023.104346}}, volume = {{105}}, year = {{2024}}, }