Advanced

Familial Mortality Risks in Patients With Heart Failure : A Swedish Sibling Study

Lindgren, Magnus P. LU ; Smith, J. Gustav LU ; Li, Xinjun LU ; Sundquist, Jan LU ; Sundquist, Kristina LU and Zöller, Bengt LU (2018) In Journal of the American Heart Association 7(24).
Abstract
Background

The influence of familial factors on the prognosis of heart failure (HF) is unknown. This nationwide follow‐up study aimed to determine familial mortality risks of HF among Swedish siblings hospitalized for HF.
Methods and Results

We linked several Swedish nationwide registers for individuals aged 0 to 80 years. The study population consisted of 373 people hospitalized for HF for the first time between 2000 and 2012 with 1 proband sibling previously hospitalized for HF for the first time between 2000 and 2007. Families with congenital heart disease were excluded. Familial hazard ratios (HRs) for mortality after first HF hospitalization were determined with Cox regression. The influence of proband survival... (More)
Background

The influence of familial factors on the prognosis of heart failure (HF) is unknown. This nationwide follow‐up study aimed to determine familial mortality risks of HF among Swedish siblings hospitalized for HF.
Methods and Results

We linked several Swedish nationwide registers for individuals aged 0 to 80 years. The study population consisted of 373 people hospitalized for HF for the first time between 2000 and 2012 with 1 proband sibling previously hospitalized for HF for the first time between 2000 and 2007. Families with congenital heart disease were excluded. Familial hazard ratios (HRs) for mortality after first HF hospitalization were determined with Cox regression. The influence of proband survival was categorized as short survival (<5 years) or long survival (≥5 years) and determined continuously for the initial 5 years of proband survival. Adjustments were made for age, sex, time period, and common HF comorbidities. Short proband survival was associated with a HR of 2.02 (95% confidence interval, 1.32–3.09) for overall mortality. This HR was 2.35 (95% confidence interval, 1.18–4.67) in patients without preceding coronary heart disease, whereas patients with ischemic HF had an HR of 1.84 (95% confidence interval, 1.05–3.23). For each year of proband survival, the risk of death decreased, with a HR of 0.86 (95% confidence interval, 0.77–0.98).
Conclusions

Our results suggest that family history of poor survival in specific relation to HF is an important risk factor for death in HF patients. Additional studies are needed to characterize the molecular underpinnings and detailed phenotypic characteristics of such patients. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of the American Heart Association
volume
7
issue
24
publisher
Wiley-Blackwell
external identifiers
  • scopus:85058773166
ISSN
2047-9980
DOI
10.1161/JAHA.118.010181
language
English
LU publication?
yes
id
1d0cb45b-5320-42a1-95f2-827ddf3dc435
date added to LUP
2018-12-18 07:54:28
date last changed
2019-06-19 03:00:34
@article{1d0cb45b-5320-42a1-95f2-827ddf3dc435,
  abstract     = {Background<br>
<br>
The influence of familial factors on the prognosis of heart failure (HF) is unknown. This nationwide follow‐up study aimed to determine familial mortality risks of HF among Swedish siblings hospitalized for HF.<br>
Methods and Results<br>
<br>
We linked several Swedish nationwide registers for individuals aged 0 to 80 years. The study population consisted of 373 people hospitalized for HF for the first time between 2000 and 2012 with 1 proband sibling previously hospitalized for HF for the first time between 2000 and 2007. Families with congenital heart disease were excluded. Familial hazard ratios (HRs) for mortality after first HF hospitalization were determined with Cox regression. The influence of proband survival was categorized as short survival (&lt;5 years) or long survival (≥5 years) and determined continuously for the initial 5 years of proband survival. Adjustments were made for age, sex, time period, and common HF comorbidities. Short proband survival was associated with a HR of 2.02 (95% confidence interval, 1.32–3.09) for overall mortality. This HR was 2.35 (95% confidence interval, 1.18–4.67) in patients without preceding coronary heart disease, whereas patients with ischemic HF had an HR of 1.84 (95% confidence interval, 1.05–3.23). For each year of proband survival, the risk of death decreased, with a HR of 0.86 (95% confidence interval, 0.77–0.98).<br>
Conclusions<br>
<br>
Our results suggest that family history of poor survival in specific relation to HF is an important risk factor for death in HF patients. Additional studies are needed to characterize the molecular underpinnings and detailed phenotypic characteristics of such patients.},
  articleno    = {e010181},
  author       = {Lindgren, Magnus P. and Smith, J. Gustav and Li, Xinjun and Sundquist, Jan and Sundquist, Kristina and Zöller, Bengt},
  issn         = {2047-9980},
  language     = {eng},
  month        = {12},
  number       = {24},
  publisher    = {Wiley-Blackwell},
  series       = {Journal of the American Heart Association},
  title        = {Familial Mortality Risks in Patients With Heart Failure : A Swedish Sibling Study},
  url          = {http://dx.doi.org/10.1161/JAHA.118.010181},
  volume       = {7},
  year         = {2018},
}