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Secular trends in prevalent mild cognitive impairment: Data from the Swedish population-based study Good Aging in Skåne

Overton, Marieclaire LU ; Pihlsgård, Mats LU and Elmståhl, Sölve LU (2022) In Alzheimer's and Dementia: Translational Research and Clinical Interventions 8(1).
Abstract
Background: Research suggests that incident dementia is decreasing, yet research
on secular trends of prodromal dementia such as mild cognitive impairment (MCI) is
lacking.
Methods: To determine change ofMCI prevalence over time and potential explanatory
factors, four baseline samples (years 2001–2020) of Swedish participants (n = 3910)
aged 60 and 81 at examination were compared.
Results: An overall drop of 9 to 10 percentage points inMCI prevalence between 2001
and 2020 was observed, with lower odds ratios (OR) forMCI in the latest birth cohorts
compared to earliest (e.g., ORs for 60-year-olds in latest born = 0.53; 95% confidence
interval [CI] 0.37–0.76). Adjustments for sociodemographic (e.g.,... (More)
Background: Research suggests that incident dementia is decreasing, yet research
on secular trends of prodromal dementia such as mild cognitive impairment (MCI) is
lacking.
Methods: To determine change ofMCI prevalence over time and potential explanatory
factors, four baseline samples (years 2001–2020) of Swedish participants (n = 3910)
aged 60 and 81 at examination were compared.
Results: An overall drop of 9 to 10 percentage points inMCI prevalence between 2001
and 2020 was observed, with lower odds ratios (OR) forMCI in the latest birth cohorts
compared to earliest (e.g., ORs for 60-year-olds in latest born = 0.53; 95% confidence
interval [CI] 0.37–0.76). Adjustments for sociodemographic (e.g., education), lifestyle,
vascular and metabolic health and depression could not fully explain the observedMCI
decline (e.g., 60-year-olds, OR = 0.59; 95% CI 0.40–0.88).
Discussion: Studies like this are imperative as even a slight postponement in the onset
of dementia could have a substantial impact on future public health burden. (Less)
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author
; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Alzheimer's and Dementia: Translational Research and Clinical Interventions
volume
8
issue
1
article number
e12260
publisher
John Wiley & Sons Inc.
external identifiers
  • scopus:85145066025
ISSN
2352-8737
DOI
10.1002/trc2.12260
language
English
LU publication?
yes
id
1d21ced7-d4ce-4c72-9e0a-f205262a8313
date added to LUP
2024-08-19 15:43:57
date last changed
2025-04-04 14:44:55
@article{1d21ced7-d4ce-4c72-9e0a-f205262a8313,
  abstract     = {{Background: Research suggests that incident dementia is decreasing, yet research<br/>on secular trends of prodromal dementia such as mild cognitive impairment (MCI) is<br/>lacking.<br/>Methods: To determine change ofMCI prevalence over time and potential explanatory<br/>factors, four baseline samples (years 2001–2020) of Swedish participants (n = 3910)<br/>aged 60 and 81 at examination were compared.<br/>Results: An overall drop of 9 to 10 percentage points inMCI prevalence between 2001<br/>and 2020 was observed, with lower odds ratios (OR) forMCI in the latest birth cohorts<br/>compared to earliest (e.g., ORs for 60-year-olds in latest born = 0.53; 95% confidence<br/>interval [CI] 0.37–0.76). Adjustments for sociodemographic (e.g., education), lifestyle,<br/>vascular and metabolic health and depression could not fully explain the observedMCI<br/>decline (e.g., 60-year-olds, OR = 0.59; 95% CI 0.40–0.88).<br/>Discussion: Studies like this are imperative as even a slight postponement in the onset<br/>of dementia could have a substantial impact on future public health burden.}},
  author       = {{Overton, Marieclaire and Pihlsgård, Mats and Elmståhl, Sölve}},
  issn         = {{2352-8737}},
  language     = {{eng}},
  month        = {{03}},
  number       = {{1}},
  publisher    = {{John Wiley & Sons Inc.}},
  series       = {{Alzheimer's and Dementia: Translational Research and Clinical Interventions}},
  title        = {{Secular trends in prevalent mild cognitive impairment: Data from the Swedish population-based study Good Aging in Skåne}},
  url          = {{http://dx.doi.org/10.1002/trc2.12260}},
  doi          = {{10.1002/trc2.12260}},
  volume       = {{8}},
  year         = {{2022}},
}