Secular trends in prevalent mild cognitive impairment: Data from the Swedish population-based study Good Aging in Skåne
(2022) In Alzheimer's and Dementia: Translational Research and Clinical Interventions 8(1).- Abstract
- Background: Research suggests that incident dementia is decreasing, yet research
on secular trends of prodromal dementia such as mild cognitive impairment (MCI) is
lacking.
Methods: To determine change ofMCI prevalence over time and potential explanatory
factors, four baseline samples (years 2001–2020) of Swedish participants (n = 3910)
aged 60 and 81 at examination were compared.
Results: An overall drop of 9 to 10 percentage points inMCI prevalence between 2001
and 2020 was observed, with lower odds ratios (OR) forMCI in the latest birth cohorts
compared to earliest (e.g., ORs for 60-year-olds in latest born = 0.53; 95% confidence
interval [CI] 0.37–0.76). Adjustments for sociodemographic (e.g.,... (More) - Background: Research suggests that incident dementia is decreasing, yet research
on secular trends of prodromal dementia such as mild cognitive impairment (MCI) is
lacking.
Methods: To determine change ofMCI prevalence over time and potential explanatory
factors, four baseline samples (years 2001–2020) of Swedish participants (n = 3910)
aged 60 and 81 at examination were compared.
Results: An overall drop of 9 to 10 percentage points inMCI prevalence between 2001
and 2020 was observed, with lower odds ratios (OR) forMCI in the latest birth cohorts
compared to earliest (e.g., ORs for 60-year-olds in latest born = 0.53; 95% confidence
interval [CI] 0.37–0.76). Adjustments for sociodemographic (e.g., education), lifestyle,
vascular and metabolic health and depression could not fully explain the observedMCI
decline (e.g., 60-year-olds, OR = 0.59; 95% CI 0.40–0.88).
Discussion: Studies like this are imperative as even a slight postponement in the onset
of dementia could have a substantial impact on future public health burden. (Less)
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https://lup.lub.lu.se/record/1d21ced7-d4ce-4c72-9e0a-f205262a8313
- author
- Overton, Marieclaire LU ; Pihlsgård, Mats LU and Elmståhl, Sölve LU
- organization
- publishing date
- 2022-03-01
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Alzheimer's and Dementia: Translational Research and Clinical Interventions
- volume
- 8
- issue
- 1
- article number
- e12260
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- scopus:85145066025
- ISSN
- 2352-8737
- DOI
- 10.1002/trc2.12260
- language
- English
- LU publication?
- yes
- id
- 1d21ced7-d4ce-4c72-9e0a-f205262a8313
- date added to LUP
- 2024-08-19 15:43:57
- date last changed
- 2024-08-20 04:00:44
@article{1d21ced7-d4ce-4c72-9e0a-f205262a8313, abstract = {{Background: Research suggests that incident dementia is decreasing, yet research<br/>on secular trends of prodromal dementia such as mild cognitive impairment (MCI) is<br/>lacking.<br/>Methods: To determine change ofMCI prevalence over time and potential explanatory<br/>factors, four baseline samples (years 2001–2020) of Swedish participants (n = 3910)<br/>aged 60 and 81 at examination were compared.<br/>Results: An overall drop of 9 to 10 percentage points inMCI prevalence between 2001<br/>and 2020 was observed, with lower odds ratios (OR) forMCI in the latest birth cohorts<br/>compared to earliest (e.g., ORs for 60-year-olds in latest born = 0.53; 95% confidence<br/>interval [CI] 0.37–0.76). Adjustments for sociodemographic (e.g., education), lifestyle,<br/>vascular and metabolic health and depression could not fully explain the observedMCI<br/>decline (e.g., 60-year-olds, OR = 0.59; 95% CI 0.40–0.88).<br/>Discussion: Studies like this are imperative as even a slight postponement in the onset<br/>of dementia could have a substantial impact on future public health burden.}}, author = {{Overton, Marieclaire and Pihlsgård, Mats and Elmståhl, Sölve}}, issn = {{2352-8737}}, language = {{eng}}, month = {{03}}, number = {{1}}, publisher = {{John Wiley & Sons Inc.}}, series = {{Alzheimer's and Dementia: Translational Research and Clinical Interventions}}, title = {{Secular trends in prevalent mild cognitive impairment: Data from the Swedish population-based study Good Aging in Skåne}}, url = {{http://dx.doi.org/10.1002/trc2.12260}}, doi = {{10.1002/trc2.12260}}, volume = {{8}}, year = {{2022}}, }