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Long-term survival of metastatic small intestine neuroendocrine tumors : a meta-analysis

Van Den Heede, Klaas LU orcid ; Chidambaram, Swathikan ; Van Slycke, Sam ; Brusselaers, Nele ; Warfvinge, Carl Fredrik LU ; Ohlsson, Håkan LU orcid ; Gustafsson, Rita LU ; Nordenström, Erik LU and Almquist, Martin LU (2022) In Endocrine-Related Cancer 29(3). p.163-173
Abstract

This meta-analysis aims to evaluate the long-term survival and prognostic factors in patients with metastatic small intestine neuroendocrine tumors (siNETs). Patients with siNETs usually present with advanced disease, limiting curative treatment options. The overall survival seems favorable compared to other cancers, but differences in terminology, lack of consistent coding, conflicting results from smaller cohorts, and recent developments of new treatment options make (reliable) survival data difficult to achieve. Nevertheless, accurate survival data are essential for many facets of health care. A systematic literature search was performed using MEDLINE®(PubMed), EMBASE®, Web of Science, and Cochrane Library up to June 30, 2021.... (More)

This meta-analysis aims to evaluate the long-term survival and prognostic factors in patients with metastatic small intestine neuroendocrine tumors (siNETs). Patients with siNETs usually present with advanced disease, limiting curative treatment options. The overall survival seems favorable compared to other cancers, but differences in terminology, lack of consistent coding, conflicting results from smaller cohorts, and recent developments of new treatment options make (reliable) survival data difficult to achieve. Nevertheless, accurate survival data are essential for many facets of health care. A systematic literature search was performed using MEDLINE®(PubMed), EMBASE®, Web of Science, and Cochrane Library up to June 30, 2021. Studies were included if the overall survival data in patients with metastatic siNETs were reported. The results were pooled in a random-effects meta-analysis and are reported as hazard ratios and 95% CIs. Subgroup analyses and meta-regression were performed to assess the observed heterogeneity and the impact of important prognostic factors. After screening 9065 abstracts, there were 23 studies, published between 1995 and 2021, that met the inclusion criteria, with a total of 8636 patients. The weighted 5- and 10-year overall survival was 67 and 37%, respectively. Meta-regression identified younger age and primary tumor resection to be associated with better prognosis. Subgroup analyses showed similar results. This study confirms that in an advanced, metastatic setting, the weighted 5- and 10-year overall survival reveal a favorable prognosis, improving over the last few decades. Meta-regression showed that age at diagnosis is an important prognostic factor.

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author
; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
meta-analysis, metastases, neuroendocrine tumors, small intestine, survival analysis, systematic review
in
Endocrine-Related Cancer
volume
29
issue
3
pages
11 pages
publisher
Society for Endocrinology
external identifiers
  • scopus:85124175519
  • pmid:34982042
ISSN
1479-6821
DOI
10.1530/ERC-21-0354
language
English
LU publication?
yes
id
1eb9b372-4c02-4e3a-9899-3fc06347d9ac
date added to LUP
2022-04-06 15:22:36
date last changed
2024-04-10 15:56:42
@article{1eb9b372-4c02-4e3a-9899-3fc06347d9ac,
  abstract     = {{<p>This meta-analysis aims to evaluate the long-term survival and prognostic factors in patients with metastatic small intestine neuroendocrine tumors (siNETs). Patients with siNETs usually present with advanced disease, limiting curative treatment options. The overall survival seems favorable compared to other cancers, but differences in terminology, lack of consistent coding, conflicting results from smaller cohorts, and recent developments of new treatment options make (reliable) survival data difficult to achieve. Nevertheless, accurate survival data are essential for many facets of health care. A systematic literature search was performed using MEDLINE®(PubMed), EMBASE®, Web of Science, and Cochrane Library up to June 30, 2021. Studies were included if the overall survival data in patients with metastatic siNETs were reported. The results were pooled in a random-effects meta-analysis and are reported as hazard ratios and 95% CIs. Subgroup analyses and meta-regression were performed to assess the observed heterogeneity and the impact of important prognostic factors. After screening 9065 abstracts, there were 23 studies, published between 1995 and 2021, that met the inclusion criteria, with a total of 8636 patients. The weighted 5- and 10-year overall survival was 67 and 37%, respectively. Meta-regression identified younger age and primary tumor resection to be associated with better prognosis. Subgroup analyses showed similar results. This study confirms that in an advanced, metastatic setting, the weighted 5- and 10-year overall survival reveal a favorable prognosis, improving over the last few decades. Meta-regression showed that age at diagnosis is an important prognostic factor.</p>}},
  author       = {{Van Den Heede, Klaas and Chidambaram, Swathikan and Van Slycke, Sam and Brusselaers, Nele and Warfvinge, Carl Fredrik and Ohlsson, Håkan and Gustafsson, Rita and Nordenström, Erik and Almquist, Martin}},
  issn         = {{1479-6821}},
  keywords     = {{meta-analysis; metastases; neuroendocrine tumors; small intestine; survival analysis; systematic review}},
  language     = {{eng}},
  number       = {{3}},
  pages        = {{163--173}},
  publisher    = {{Society for Endocrinology}},
  series       = {{Endocrine-Related Cancer}},
  title        = {{Long-term survival of metastatic small intestine neuroendocrine tumors : a meta-analysis}},
  url          = {{http://dx.doi.org/10.1530/ERC-21-0354}},
  doi          = {{10.1530/ERC-21-0354}},
  volume       = {{29}},
  year         = {{2022}},
}