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Effects on fetal and maternal temperatures of paracetamol administration during labour: a case-control study.

Lavesson, Tony LU ; Akerman, Fernanda; Källén, Karin LU and Olofsson, Per LU (2013) In European Journal of Obstetrics, Gynecology, and Reproductive Biology 168(2). p.138-144
Abstract
OBJECTIVE: To study the effect of paracetamol (acetaminophen) on maternal and fetal temperatures in labour. STUDY DESIGN: From a cohort of 185 women with continuous maternal axillary and fetal scalp temperature recordings in labour, 18 women treated with 1000mg paracetamol orally for pyrexia and 36 untreated controls matched for parity, cervical dilatation, and epidural analgesia were selected. Electronically stored temperature data were analysed offline post hoc. The dual temperatures recorded every 30min from 60min before (T-60) paracetamol administration (T0) until delivery, were noted. Longitudinal data were compared with Wilcoxon matched-pairs signed-ranks test and cross-sectional data with Mann-Whitney U test. Shapes of the... (More)
OBJECTIVE: To study the effect of paracetamol (acetaminophen) on maternal and fetal temperatures in labour. STUDY DESIGN: From a cohort of 185 women with continuous maternal axillary and fetal scalp temperature recordings in labour, 18 women treated with 1000mg paracetamol orally for pyrexia and 36 untreated controls matched for parity, cervical dilatation, and epidural analgesia were selected. Electronically stored temperature data were analysed offline post hoc. The dual temperatures recorded every 30min from 60min before (T-60) paracetamol administration (T0) until delivery, were noted. Longitudinal data were compared with Wilcoxon matched-pairs signed-ranks test and cross-sectional data with Mann-Whitney U test. Shapes of the temperature curves were compared with mixed-effect models statistics for repeated measurements. The main outcome measures were temperature changes after paracetamol. A two-tailed P<0.05 was considered significant. RESULTS: Prior to T0 maternal and fetal temperatures increased in the paracetamol group, but after T0 no significant changes (P≥0.1) were seen when compared with Wilcoxon signed-ranks test. In the control group, both temperatures increased from T-60 and onwards. Delta-temperatures (fetal minus maternal temperature) remained unchanged in both groups. Analyses of the mixed-effect models showed a significant difference (P=0.01) in the shape of fetal temperature curves between the paracetamol and control groups, but no significant difference (P=0.4) in maternal temperature curve shapes. CONCLUSION: In febrile parturients, neither maternal nor fetal temperatures dropped after paracetamol, but paracetamol halted an increasing trend and stabilised the fetal temperature. The effect of paracetamol on maternal temperature was inconclusive. (Less)
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author
organization
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type
Contribution to journal
publication status
published
subject
in
European Journal of Obstetrics, Gynecology, and Reproductive Biology
volume
168
issue
2
pages
138 - 144
publisher
Elsevier
external identifiers
  • wos:000320834500004
  • pmid:23375211
  • scopus:84878509860
ISSN
0301-2115
DOI
10.1016/j.ejogrb.2012.12.033
language
English
LU publication?
yes
id
1ebc9b00-de20-4643-8703-1fd30a3525cd (old id 3560261)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/23375211?dopt=Abstract
date added to LUP
2013-03-01 12:44:49
date last changed
2019-01-06 03:58:18
@article{1ebc9b00-de20-4643-8703-1fd30a3525cd,
  abstract     = {OBJECTIVE: To study the effect of paracetamol (acetaminophen) on maternal and fetal temperatures in labour. STUDY DESIGN: From a cohort of 185 women with continuous maternal axillary and fetal scalp temperature recordings in labour, 18 women treated with 1000mg paracetamol orally for pyrexia and 36 untreated controls matched for parity, cervical dilatation, and epidural analgesia were selected. Electronically stored temperature data were analysed offline post hoc. The dual temperatures recorded every 30min from 60min before (T-60) paracetamol administration (T0) until delivery, were noted. Longitudinal data were compared with Wilcoxon matched-pairs signed-ranks test and cross-sectional data with Mann-Whitney U test. Shapes of the temperature curves were compared with mixed-effect models statistics for repeated measurements. The main outcome measures were temperature changes after paracetamol. A two-tailed P&lt;0.05 was considered significant. RESULTS: Prior to T0 maternal and fetal temperatures increased in the paracetamol group, but after T0 no significant changes (P≥0.1) were seen when compared with Wilcoxon signed-ranks test. In the control group, both temperatures increased from T-60 and onwards. Delta-temperatures (fetal minus maternal temperature) remained unchanged in both groups. Analyses of the mixed-effect models showed a significant difference (P=0.01) in the shape of fetal temperature curves between the paracetamol and control groups, but no significant difference (P=0.4) in maternal temperature curve shapes. CONCLUSION: In febrile parturients, neither maternal nor fetal temperatures dropped after paracetamol, but paracetamol halted an increasing trend and stabilised the fetal temperature. The effect of paracetamol on maternal temperature was inconclusive.},
  author       = {Lavesson, Tony and Akerman, Fernanda and Källén, Karin and Olofsson, Per},
  issn         = {0301-2115},
  language     = {eng},
  number       = {2},
  pages        = {138--144},
  publisher    = {Elsevier},
  series       = {European Journal of Obstetrics, Gynecology, and Reproductive Biology},
  title        = {Effects on fetal and maternal temperatures of paracetamol administration during labour: a case-control study.},
  url          = {http://dx.doi.org/10.1016/j.ejogrb.2012.12.033},
  volume       = {168},
  year         = {2013},
}