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Change in autoantibody and cytokine responses during the evolution of neuromyelitis optica in patients with systemic lupus erythematosus : A preliminary study

Kovacs, Katalin T. ; Kalluri, Sudhakar Reddy ; Boza-Serrano, Antonio LU ; Deierborg, Tomas LU orcid ; Csepany, Tunde ; Simo, Magdolna ; Rokusz, Laszlo ; Miseta, Attila ; Alcaraz, Nicolas and Czirjak, Laszlo , et al. (2016) In Multiple Sclerosis Journal 22(9). p.1192-1201
Abstract

Background: Neuromyelitis optica (NMO)-systemic lupus erythematosus (SLE) association is a rare condition characterized by multiple autoantibodies. Objective: To examine if, during the evolution of NMO, anti-AQP4 responses are part of polyclonal B cell activation, and if T cell responses contribute. Methods: In 19 samples of six patients who developed NMO during SLE, we examined the correlation of AQP4-IgG1 and IgM with (i) anti-MOG IgG and IgM, (ii) anti-nuclear, anti-nucleosome and anti-dsDNA IgG antibodies, (iii) cytokines and chemokines in the serum and (iv) longitudinal relation to NMO relapses/remission. Results: AQP4-IgG1 was present 1-2-5 years before the first NMO relapse. During relapse, AQP4-IgG1, ANA, anti-dsDNA and... (More)

Background: Neuromyelitis optica (NMO)-systemic lupus erythematosus (SLE) association is a rare condition characterized by multiple autoantibodies. Objective: To examine if, during the evolution of NMO, anti-AQP4 responses are part of polyclonal B cell activation, and if T cell responses contribute. Methods: In 19 samples of six patients who developed NMO during SLE, we examined the correlation of AQP4-IgG1 and IgM with (i) anti-MOG IgG and IgM, (ii) anti-nuclear, anti-nucleosome and anti-dsDNA IgG antibodies, (iii) cytokines and chemokines in the serum and (iv) longitudinal relation to NMO relapses/remission. Results: AQP4-IgG1 was present 1-2-5 years before the first NMO relapse. During relapse, AQP4-IgG1, ANA, anti-dsDNA and anti-nucleosome antibodies were elevated. Anti-MOG IgG/IgM and AQP4-IgM antibodies were not detected. AQP4-IgG1 antibodies correlated with concentration of anti-nucleosome, IFN-γ,interferon-gamma-induced CCL10/IP-10 and CCL17/TARC (p

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
AQP4, IL-17, IP-10, myelin oligodendrocyte glycoprotein, SLE, Th1, Th17
in
Multiple Sclerosis Journal
volume
22
issue
9
pages
10 pages
publisher
SAGE Publications
external identifiers
  • scopus:84979515569
  • wos:000380995800012
  • pmid:26514978
ISSN
1352-4585
DOI
10.1177/1352458515613165
language
English
LU publication?
yes
id
1f348f9e-15cf-446e-b5a6-3d9a1e08c536
date added to LUP
2016-08-29 13:28:26
date last changed
2025-04-04 14:32:45
@article{1f348f9e-15cf-446e-b5a6-3d9a1e08c536,
  abstract     = {{<p>Background: Neuromyelitis optica (NMO)-systemic lupus erythematosus (SLE) association is a rare condition characterized by multiple autoantibodies. Objective: To examine if, during the evolution of NMO, anti-AQP4 responses are part of polyclonal B cell activation, and if T cell responses contribute. Methods: In 19 samples of six patients who developed NMO during SLE, we examined the correlation of AQP4-IgG1 and IgM with (i) anti-MOG IgG and IgM, (ii) anti-nuclear, anti-nucleosome and anti-dsDNA IgG antibodies, (iii) cytokines and chemokines in the serum and (iv) longitudinal relation to NMO relapses/remission. Results: AQP4-IgG1 was present 1-2-5 years before the first NMO relapse. During relapse, AQP4-IgG1, ANA, anti-dsDNA and anti-nucleosome antibodies were elevated. Anti-MOG IgG/IgM and AQP4-IgM antibodies were not detected. AQP4-IgG1 antibodies correlated with concentration of anti-nucleosome, IFN-γ,interferon-gamma-induced CCL10/IP-10 and CCL17/TARC (p</p>}},
  author       = {{Kovacs, Katalin T. and Kalluri, Sudhakar Reddy and Boza-Serrano, Antonio and Deierborg, Tomas and Csepany, Tunde and Simo, Magdolna and Rokusz, Laszlo and Miseta, Attila and Alcaraz, Nicolas and Czirjak, Laszlo and Berki, Timea and Molnar, Tihamer and Hemmer, Bernhard and Illes, Zsolt}},
  issn         = {{1352-4585}},
  keywords     = {{AQP4; IL-17; IP-10; myelin oligodendrocyte glycoprotein; SLE; Th1; Th17}},
  language     = {{eng}},
  month        = {{08}},
  number       = {{9}},
  pages        = {{1192--1201}},
  publisher    = {{SAGE Publications}},
  series       = {{Multiple Sclerosis Journal}},
  title        = {{Change in autoantibody and cytokine responses during the evolution of neuromyelitis optica in patients with systemic lupus erythematosus : A preliminary study}},
  url          = {{http://dx.doi.org/10.1177/1352458515613165}},
  doi          = {{10.1177/1352458515613165}},
  volume       = {{22}},
  year         = {{2016}},
}