Airspace Dimension Assessment with Nanoparticles (AiDA) in Comparison to Established Pulmonary Function Tests
(2022) In International Journal of Nanomedicine 17. p.2777-2790- Abstract
Background: Airspace Dimensions Assessment with nanoparticles (AiDA) is a new method for non-invasive measurement of pulmonary distal airspaces. The aim of this study was to compare AiDA measurements with other pulmonary function variables to better understand the potential of AiDA in a clinical context. Methods: AiDA measurements and pulmonary function tests were performed in 695 subjects as part of the Swedish CArdioPulmonary bioImage Study. The measurement protocol included spirometry, measurement of diffusing capacity of carbon monoxide, oscillometry and pulmonary computed tomography. AiDA indices were compared to all other pulmonary examination measurements using multivariate statistical analysis. Results: Our results show that... (More)
Background: Airspace Dimensions Assessment with nanoparticles (AiDA) is a new method for non-invasive measurement of pulmonary distal airspaces. The aim of this study was to compare AiDA measurements with other pulmonary function variables to better understand the potential of AiDA in a clinical context. Methods: AiDA measurements and pulmonary function tests were performed in 695 subjects as part of the Swedish CArdioPulmonary bioImage Study. The measurement protocol included spirometry, measurement of diffusing capacity of carbon monoxide, oscillometry and pulmonary computed tomography. AiDA indices were compared to all other pulmonary examination measurements using multivariate statistical analysis. Results: Our results show that AiDA measurements were significantly correlated with other pulmonary function examination indices, although covariance was low. We found that AiDA variables explained variance in the data that other lung function variables only influenced to a minor extent. Conclusion: We conclude that the AiDA method provides information about the lung that is inaccessible with more conventional lung function techniques.
(Less)
- author
- Petersson-Sjögren, Madeleine LU ; Jakobsson, Jonas LU ; Aaltonen, H. Laura LU ; Nicklasson, Hanna LU ; Rissler, Jenny LU ; Engström, Gunnar LU ; Wollmer, Per LU and Löndahl, Jakob LU
- organization
-
- LTH Profile Area: Nanoscience and Semiconductor Technology
- LTH Profile Area: Aerosols
- NanoLund: Centre for Nanoscience
- Ergonomics and Aerosol Technology
- Nuclear physics
- Radiology Diagnostics, Malmö (research group)
- Cardiovascular Research - Epidemiology (research group)
- EpiHealth: Epidemiology for Health
- LTH Profile Area: Engineering Health
- publishing date
- 2022
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- aerosol nanoparticles, airspace dimension assessment with nanoparticles, COPD diagnostics, distal airspaces, respiratory diagnostics with nanoparticles
- in
- International Journal of Nanomedicine
- volume
- 17
- pages
- 14 pages
- publisher
- Dove Medical Press Ltd.
- external identifiers
-
- pmid:35782019
- scopus:85133256379
- ISSN
- 1176-9114
- DOI
- 10.2147/IJN.S360271
- language
- English
- LU publication?
- yes
- id
- 1f57ae65-53c2-4433-8e74-c8a4c34c3a28
- date added to LUP
- 2022-10-04 09:34:05
- date last changed
- 2024-09-20 01:13:21
@article{1f57ae65-53c2-4433-8e74-c8a4c34c3a28, abstract = {{<p>Background: Airspace Dimensions Assessment with nanoparticles (AiDA) is a new method for non-invasive measurement of pulmonary distal airspaces. The aim of this study was to compare AiDA measurements with other pulmonary function variables to better understand the potential of AiDA in a clinical context. Methods: AiDA measurements and pulmonary function tests were performed in 695 subjects as part of the Swedish CArdioPulmonary bioImage Study. The measurement protocol included spirometry, measurement of diffusing capacity of carbon monoxide, oscillometry and pulmonary computed tomography. AiDA indices were compared to all other pulmonary examination measurements using multivariate statistical analysis. Results: Our results show that AiDA measurements were significantly correlated with other pulmonary function examination indices, although covariance was low. We found that AiDA variables explained variance in the data that other lung function variables only influenced to a minor extent. Conclusion: We conclude that the AiDA method provides information about the lung that is inaccessible with more conventional lung function techniques.</p>}}, author = {{Petersson-Sjögren, Madeleine and Jakobsson, Jonas and Aaltonen, H. Laura and Nicklasson, Hanna and Rissler, Jenny and Engström, Gunnar and Wollmer, Per and Löndahl, Jakob}}, issn = {{1176-9114}}, keywords = {{aerosol nanoparticles; airspace dimension assessment with nanoparticles; COPD diagnostics; distal airspaces; respiratory diagnostics with nanoparticles}}, language = {{eng}}, pages = {{2777--2790}}, publisher = {{Dove Medical Press Ltd.}}, series = {{International Journal of Nanomedicine}}, title = {{Airspace Dimension Assessment with Nanoparticles (AiDA) in Comparison to Established Pulmonary Function Tests}}, url = {{http://dx.doi.org/10.2147/IJN.S360271}}, doi = {{10.2147/IJN.S360271}}, volume = {{17}}, year = {{2022}}, }