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Airspace Dimension Assessment with Nanoparticles (AiDA) in Comparison to Established Pulmonary Function Tests

Petersson-Sjögren, Madeleine LU ; Jakobsson, Jonas LU ; Aaltonen, H. Laura LU ; Nicklasson, Hanna LU ; Rissler, Jenny LU ; Engström, Gunnar LU ; Wollmer, Per LU and Löndahl, Jakob LU orcid (2022) In International Journal of Nanomedicine 17. p.2777-2790
Abstract

Background: Airspace Dimensions Assessment with nanoparticles (AiDA) is a new method for non-invasive measurement of pulmonary distal airspaces. The aim of this study was to compare AiDA measurements with other pulmonary function variables to better understand the potential of AiDA in a clinical context. Methods: AiDA measurements and pulmonary function tests were performed in 695 subjects as part of the Swedish CArdioPulmonary bioImage Study. The measurement protocol included spirometry, measurement of diffusing capacity of carbon monoxide, oscillometry and pulmonary computed tomography. AiDA indices were compared to all other pulmonary examination measurements using multivariate statistical analysis. Results: Our results show that... (More)

Background: Airspace Dimensions Assessment with nanoparticles (AiDA) is a new method for non-invasive measurement of pulmonary distal airspaces. The aim of this study was to compare AiDA measurements with other pulmonary function variables to better understand the potential of AiDA in a clinical context. Methods: AiDA measurements and pulmonary function tests were performed in 695 subjects as part of the Swedish CArdioPulmonary bioImage Study. The measurement protocol included spirometry, measurement of diffusing capacity of carbon monoxide, oscillometry and pulmonary computed tomography. AiDA indices were compared to all other pulmonary examination measurements using multivariate statistical analysis. Results: Our results show that AiDA measurements were significantly correlated with other pulmonary function examination indices, although covariance was low. We found that AiDA variables explained variance in the data that other lung function variables only influenced to a minor extent. Conclusion: We conclude that the AiDA method provides information about the lung that is inaccessible with more conventional lung function techniques.

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author
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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
aerosol nanoparticles, airspace dimension assessment with nanoparticles, COPD diagnostics, distal airspaces, respiratory diagnostics with nanoparticles
in
International Journal of Nanomedicine
volume
17
pages
14 pages
publisher
Dove Medical Press Ltd.
external identifiers
  • scopus:85133256379
  • pmid:35782019
ISSN
1176-9114
DOI
10.2147/IJN.S360271
language
English
LU publication?
yes
id
1f57ae65-53c2-4433-8e74-c8a4c34c3a28
date added to LUP
2022-10-04 09:34:05
date last changed
2024-05-30 15:08:48
@article{1f57ae65-53c2-4433-8e74-c8a4c34c3a28,
  abstract     = {{<p>Background: Airspace Dimensions Assessment with nanoparticles (AiDA) is a new method for non-invasive measurement of pulmonary distal airspaces. The aim of this study was to compare AiDA measurements with other pulmonary function variables to better understand the potential of AiDA in a clinical context. Methods: AiDA measurements and pulmonary function tests were performed in 695 subjects as part of the Swedish CArdioPulmonary bioImage Study. The measurement protocol included spirometry, measurement of diffusing capacity of carbon monoxide, oscillometry and pulmonary computed tomography. AiDA indices were compared to all other pulmonary examination measurements using multivariate statistical analysis. Results: Our results show that AiDA measurements were significantly correlated with other pulmonary function examination indices, although covariance was low. We found that AiDA variables explained variance in the data that other lung function variables only influenced to a minor extent. Conclusion: We conclude that the AiDA method provides information about the lung that is inaccessible with more conventional lung function techniques.</p>}},
  author       = {{Petersson-Sjögren, Madeleine and Jakobsson, Jonas and Aaltonen, H. Laura and Nicklasson, Hanna and Rissler, Jenny and Engström, Gunnar and Wollmer, Per and Löndahl, Jakob}},
  issn         = {{1176-9114}},
  keywords     = {{aerosol nanoparticles; airspace dimension assessment with nanoparticles; COPD diagnostics; distal airspaces; respiratory diagnostics with nanoparticles}},
  language     = {{eng}},
  pages        = {{2777--2790}},
  publisher    = {{Dove Medical Press Ltd.}},
  series       = {{International Journal of Nanomedicine}},
  title        = {{Airspace Dimension Assessment with Nanoparticles (AiDA) in Comparison to Established Pulmonary Function Tests}},
  url          = {{http://dx.doi.org/10.2147/IJN.S360271}},
  doi          = {{10.2147/IJN.S360271}},
  volume       = {{17}},
  year         = {{2022}},
}