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Genotyping of human papillomavirus in triaging of low-grade cervical cytology.

Söderlund Strand, Anna LU ; Eklund, Carina LU ; Kemetli, Levent; Grillner, Lena; Törnberg, Sven; Dillner, Joakim LU and Dillner, Lena LU (2011) In American Journal of Obstetrics and Gynecology 205(2). p.1-145
Abstract
OBJECTIVE: The objective of the study was to evaluate whether typing of human papillomavirus (HPV) among women with low-grade cervical cytology can improve the ability to identify women with cervical cancer or cervical intraepithelial neoplasia grade III (CIN III or worse). STUDY DESIGN: A total of 1595 women with low-grade cervical cytology participating in a randomized implementation trial of HPV triaging using Hybrid Capture II were also HPV genotyped and CIN III or worse predictive values evaluated. RESULTS: HPV 16 was detected in 57% of cases with CIN III or worse but only among 24% of all tested women. Testing for the 3 HPV types with highest risk (HPV16/31/33) detected 77% of CIN III or worse, with 36% of women testing positive.... (More)
OBJECTIVE: The objective of the study was to evaluate whether typing of human papillomavirus (HPV) among women with low-grade cervical cytology can improve the ability to identify women with cervical cancer or cervical intraepithelial neoplasia grade III (CIN III or worse). STUDY DESIGN: A total of 1595 women with low-grade cervical cytology participating in a randomized implementation trial of HPV triaging using Hybrid Capture II were also HPV genotyped and CIN III or worse predictive values evaluated. RESULTS: HPV 16 was detected in 57% of cases with CIN III or worse but only among 24% of all tested women. Testing for the 3 HPV types with highest risk (HPV16/31/33) detected 77% of CIN III or worse, with 36% of women testing positive. Positivity for the other high-risk HPV types had a decreased risk for CIN III or worse. CONCLUSION: Different high-risk HPV types confer different risks for the presence of CIN III or worse, implying that HPV genotyping could be useful for the optimization of triaging strategies. (Less)
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type
Contribution to journal
publication status
published
subject
in
American Journal of Obstetrics and Gynecology
volume
205
issue
2
pages
1 - 145
publisher
Elsevier
external identifiers
  • wos:000293219400031
  • pmid:21658668
  • scopus:79960909426
ISSN
1097-6868
DOI
10.1016/j.ajog.2011.03.056
language
English
LU publication?
yes
id
53ced846-8d74-4f75-bae0-fb2c9fdeb259 (old id 2008262)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/21658668?dopt=Abstract
date added to LUP
2011-07-04 13:28:01
date last changed
2017-07-09 03:20:15
@article{53ced846-8d74-4f75-bae0-fb2c9fdeb259,
  abstract     = {OBJECTIVE: The objective of the study was to evaluate whether typing of human papillomavirus (HPV) among women with low-grade cervical cytology can improve the ability to identify women with cervical cancer or cervical intraepithelial neoplasia grade III (CIN III or worse). STUDY DESIGN: A total of 1595 women with low-grade cervical cytology participating in a randomized implementation trial of HPV triaging using Hybrid Capture II were also HPV genotyped and CIN III or worse predictive values evaluated. RESULTS: HPV 16 was detected in 57% of cases with CIN III or worse but only among 24% of all tested women. Testing for the 3 HPV types with highest risk (HPV16/31/33) detected 77% of CIN III or worse, with 36% of women testing positive. Positivity for the other high-risk HPV types had a decreased risk for CIN III or worse. CONCLUSION: Different high-risk HPV types confer different risks for the presence of CIN III or worse, implying that HPV genotyping could be useful for the optimization of triaging strategies.},
  author       = {Söderlund Strand, Anna and Eklund, Carina and Kemetli, Levent and Grillner, Lena and Törnberg, Sven and Dillner, Joakim and Dillner, Lena},
  issn         = {1097-6868},
  language     = {eng},
  number       = {2},
  pages        = {1--145},
  publisher    = {Elsevier},
  series       = {American Journal of Obstetrics and Gynecology},
  title        = {Genotyping of human papillomavirus in triaging of low-grade cervical cytology.},
  url          = {http://dx.doi.org/10.1016/j.ajog.2011.03.056},
  volume       = {205},
  year         = {2011},
}