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Gastrointestinal dysfunction contributes to weight loss in Huntington's disease mice.

van der Burg, Jorien m; Winqvist, Annika LU ; Aziz, N Ahmad; Maat-Schieman, Marion L C; Roos, Raymund A C; Bates, Gillian P; Brundin, Patrik LU ; Björkqvist, Maria LU and Wierup, Nils LU (2011) In Neurobiology of Disease 44. p.1-8
Abstract
Weight loss is the most important non-neurological complication of Huntington's disease (HD). It correlates with disease progression and affects the quality of life of HD patients, suggesting that it could be a valuable target for therapeutic intervention. The mechanism underlying weight loss in HD is unknown. Mutant huntingtin, the protein that causes the disease, is not only expressed in the brain, but also along the gastrointestinal (GI) tract. Here we demonstrate that the GI tract of HD mice is affected. At the anatomical level we observed loss of enteric neuropeptides, as well as decreased mucosal thickness and villus length. Exploring the functions of the GI system we found impaired gut motility, diarrhea, and malabsorption of food.... (More)
Weight loss is the most important non-neurological complication of Huntington's disease (HD). It correlates with disease progression and affects the quality of life of HD patients, suggesting that it could be a valuable target for therapeutic intervention. The mechanism underlying weight loss in HD is unknown. Mutant huntingtin, the protein that causes the disease, is not only expressed in the brain, but also along the gastrointestinal (GI) tract. Here we demonstrate that the GI tract of HD mice is affected. At the anatomical level we observed loss of enteric neuropeptides, as well as decreased mucosal thickness and villus length. Exploring the functions of the GI system we found impaired gut motility, diarrhea, and malabsorption of food. The degree of malabsorption was inversely associated with body weight, suggesting that GI dysfunction plays an important role in weight loss in HD mice. In summary, these observations suggest that the GI tract is affected in HD mice and that GI dysfunction contributes to nutritional deficiencies and weight loss. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Neurobiology of Disease
volume
44
pages
1 - 8
publisher
Elsevier
external identifiers
  • wos:000294197700001
  • pmid:21624468
  • scopus:79961127043
ISSN
0969-9961
DOI
10.1016/j.nbd.2011.05.006
language
English
LU publication?
yes
id
f89ce500-f96a-4306-b4d4-8ed808f10b90 (old id 2008697)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/21624468?dopt=Abstract
date added to LUP
2011-07-01 11:13:06
date last changed
2017-11-05 04:43:19
@article{f89ce500-f96a-4306-b4d4-8ed808f10b90,
  abstract     = {Weight loss is the most important non-neurological complication of Huntington's disease (HD). It correlates with disease progression and affects the quality of life of HD patients, suggesting that it could be a valuable target for therapeutic intervention. The mechanism underlying weight loss in HD is unknown. Mutant huntingtin, the protein that causes the disease, is not only expressed in the brain, but also along the gastrointestinal (GI) tract. Here we demonstrate that the GI tract of HD mice is affected. At the anatomical level we observed loss of enteric neuropeptides, as well as decreased mucosal thickness and villus length. Exploring the functions of the GI system we found impaired gut motility, diarrhea, and malabsorption of food. The degree of malabsorption was inversely associated with body weight, suggesting that GI dysfunction plays an important role in weight loss in HD mice. In summary, these observations suggest that the GI tract is affected in HD mice and that GI dysfunction contributes to nutritional deficiencies and weight loss.},
  author       = {van der Burg, Jorien m and Winqvist, Annika and Aziz, N Ahmad and Maat-Schieman, Marion L C and Roos, Raymund A C and Bates, Gillian P and Brundin, Patrik and Björkqvist, Maria and Wierup, Nils},
  issn         = {0969-9961},
  language     = {eng},
  pages        = {1--8},
  publisher    = {Elsevier},
  series       = {Neurobiology of Disease},
  title        = {Gastrointestinal dysfunction contributes to weight loss in Huntington's disease mice.},
  url          = {http://dx.doi.org/10.1016/j.nbd.2011.05.006},
  volume       = {44},
  year         = {2011},
}