Gastrointestinal dysfunction contributes to weight loss in Huntington's disease mice.
van der Burg, Jorien m ; Winqvist, Annika LU ; Aziz, N Ahmad ; Maat-Schieman, Marion L C ; Roos, Raymund A C ; Bates, Gillian P ; Brundin, Patrik LU ; Björkqvist, Maria LU
and Wierup, Nils
LU
(2011)
In Neurobiology of Disease
44.
p.1-8
- Abstract
- Weight loss is the most important non-neurological complication of Huntington's disease (HD). It correlates with disease progression and affects the quality of life of HD patients, suggesting that it could be a valuable target for therapeutic intervention. The mechanism underlying weight loss in HD is unknown. Mutant huntingtin, the protein that causes the disease, is not only expressed in the brain, but also along the gastrointestinal (GI) tract. Here we demonstrate that the GI tract of HD mice is affected. At the anatomical level we observed loss of enteric neuropeptides, as well as decreased mucosal thickness and villus length. Exploring the functions of the GI system we found impaired gut motility, diarrhea, and malabsorption of food.... (More)
- Weight loss is the most important non-neurological complication of Huntington's disease (HD). It correlates with disease progression and affects the quality of life of HD patients, suggesting that it could be a valuable target for therapeutic intervention. The mechanism underlying weight loss in HD is unknown. Mutant huntingtin, the protein that causes the disease, is not only expressed in the brain, but also along the gastrointestinal (GI) tract. Here we demonstrate that the GI tract of HD mice is affected. At the anatomical level we observed loss of enteric neuropeptides, as well as decreased mucosal thickness and villus length. Exploring the functions of the GI system we found impaired gut motility, diarrhea, and malabsorption of food. The degree of malabsorption was inversely associated with body weight, suggesting that GI dysfunction plays an important role in weight loss in HD mice. In summary, these observations suggest that the GI tract is affected in HD mice and that GI dysfunction contributes to nutritional deficiencies and weight loss. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/2008697
- author
- van der Burg, Jorien m
; Winqvist, Annika
LU
; Aziz, N Ahmad
; Maat-Schieman, Marion L C
; Roos, Raymund A C
; Bates, Gillian P
; Brundin, Patrik
LU
; Björkqvist, Maria
LU
and Wierup, Nils
LU
- organization
- publishing date
- 2011
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Neurobiology of Disease
- volume
- 44
- pages
- 1 - 8
- publisher
- Elsevier
- external identifiers
-
- wos:000294197700001
- pmid:21624468
- scopus:79961127043
- pmid:21624468
- ISSN
- 0969-9961
- DOI
- 10.1016/j.nbd.2011.05.006
- language
- English
- LU publication?
- yes
- id
- f89ce500-f96a-4306-b4d4-8ed808f10b90 (old id 2008697)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/21624468?dopt=Abstract
- date added to LUP
- 2016-04-04 08:33:19
- date last changed
- 2023-09-05 15:41:09
@article{f89ce500-f96a-4306-b4d4-8ed808f10b90,
abstract = {{Weight loss is the most important non-neurological complication of Huntington's disease (HD). It correlates with disease progression and affects the quality of life of HD patients, suggesting that it could be a valuable target for therapeutic intervention. The mechanism underlying weight loss in HD is unknown. Mutant huntingtin, the protein that causes the disease, is not only expressed in the brain, but also along the gastrointestinal (GI) tract. Here we demonstrate that the GI tract of HD mice is affected. At the anatomical level we observed loss of enteric neuropeptides, as well as decreased mucosal thickness and villus length. Exploring the functions of the GI system we found impaired gut motility, diarrhea, and malabsorption of food. The degree of malabsorption was inversely associated with body weight, suggesting that GI dysfunction plays an important role in weight loss in HD mice. In summary, these observations suggest that the GI tract is affected in HD mice and that GI dysfunction contributes to nutritional deficiencies and weight loss.}},
author = {{van der Burg, Jorien m and Winqvist, Annika and Aziz, N Ahmad and Maat-Schieman, Marion L C and Roos, Raymund A C and Bates, Gillian P and Brundin, Patrik and Björkqvist, Maria and Wierup, Nils}},
issn = {{0969-9961}},
language = {{eng}},
pages = {{1--8}},
publisher = {{Elsevier}},
series = {{Neurobiology of Disease}},
title = {{Gastrointestinal dysfunction contributes to weight loss in Huntington's disease mice.}},
url = {{http://dx.doi.org/10.1016/j.nbd.2011.05.006}},
doi = {{10.1016/j.nbd.2011.05.006}},
volume = {{44}},
year = {{2011}},
}