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Relation Between Growth And Bone Collagen Content In Young Pigs; Effects Of Dietary Alpha-Ketoglutarate Supplementation

Kowalik, Sylwester; Wawrzyniak-Gacek, Agata; Piersiak, Tomasz and Pierzynowski, Stefan LU (2011) In Bulletin of the Veterinary Institute in Puławy 55(2). p.287-292
Abstract
The aim of this study was to determine the effect of dietary supplementation with alpha-ketoglutarate (AKG) sodium salt on growth rate in relation to bone collagen formation during the first 70 d of postnatal life in piglets. The results show that dietary AKG supplementation increased body weight of the experimental piglets in comparison to the controls, especially between 21(st) and 56(th) d of life (P <= 0.01). Moreover, the area of collagen trabeculae slightly increased in experimental age sub-groups and reached the highest differences between 14(th) (P <= 0.01) and 70(th) d of piglets life (P <= 0.001). In contrast, the highest values for the number of collagen trabeculae were observed in piglets at 3(rd) d of age, regardless... (More)
The aim of this study was to determine the effect of dietary supplementation with alpha-ketoglutarate (AKG) sodium salt on growth rate in relation to bone collagen formation during the first 70 d of postnatal life in piglets. The results show that dietary AKG supplementation increased body weight of the experimental piglets in comparison to the controls, especially between 21(st) and 56(th) d of life (P <= 0.01). Moreover, the area of collagen trabeculae slightly increased in experimental age sub-groups and reached the highest differences between 14(th) (P <= 0.01) and 70(th) d of piglets life (P <= 0.001). In contrast, the highest values for the number of collagen trabeculae were observed in piglets at 3(rd) d of age, regardless of treatment group. The positive effect of AKG supplementation on the number of collagen trabeculae was found between 3(rd) and 35(th) d of life, with statistical confirmation at days 14, 35, and 56 (P <= 0.01). The data-lines of the bone strain showed similar course during the whole experimental period, except 56(th) d of life, when the experimental piglets reached statistically significant, higher values in comparison to the controls (P <= 0.05). Similarly, the blood plasma osteocalcin reached the highest concentration in experimental sub-groups from 21(st) d of life in comparison to the controls, with statistical significance at the age of 56 (P <= 0.05). These data indicate that dietary AKG supplementation effectively stimulated collagen synthesis in young growing piglets, both before and after weaning. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
piglets, bone, collagen, alpha-ketoglutarate
in
Bulletin of the Veterinary Institute in Puławy
volume
55
issue
2
pages
287 - 292
publisher
National Veterinary Research Institute
external identifiers
  • wos:000292488900021
ISSN
0042-4870
language
English
LU publication?
yes
id
1cf63387-b451-4408-b118-1b2e7dc77bef (old id 2029086)
alternative location
http://bulletin.piwet.pulawy.pl/images/stories/pdf/20112/20112287292.pdf
date added to LUP
2011-07-26 14:04:24
date last changed
2016-04-15 23:18:10
@article{1cf63387-b451-4408-b118-1b2e7dc77bef,
  abstract     = {The aim of this study was to determine the effect of dietary supplementation with alpha-ketoglutarate (AKG) sodium salt on growth rate in relation to bone collagen formation during the first 70 d of postnatal life in piglets. The results show that dietary AKG supplementation increased body weight of the experimental piglets in comparison to the controls, especially between 21(st) and 56(th) d of life (P &lt;= 0.01). Moreover, the area of collagen trabeculae slightly increased in experimental age sub-groups and reached the highest differences between 14(th) (P &lt;= 0.01) and 70(th) d of piglets life (P &lt;= 0.001). In contrast, the highest values for the number of collagen trabeculae were observed in piglets at 3(rd) d of age, regardless of treatment group. The positive effect of AKG supplementation on the number of collagen trabeculae was found between 3(rd) and 35(th) d of life, with statistical confirmation at days 14, 35, and 56 (P &lt;= 0.01). The data-lines of the bone strain showed similar course during the whole experimental period, except 56(th) d of life, when the experimental piglets reached statistically significant, higher values in comparison to the controls (P &lt;= 0.05). Similarly, the blood plasma osteocalcin reached the highest concentration in experimental sub-groups from 21(st) d of life in comparison to the controls, with statistical significance at the age of 56 (P &lt;= 0.05). These data indicate that dietary AKG supplementation effectively stimulated collagen synthesis in young growing piglets, both before and after weaning.},
  author       = {Kowalik, Sylwester and Wawrzyniak-Gacek, Agata and Piersiak, Tomasz and Pierzynowski, Stefan},
  issn         = {0042-4870},
  keyword      = {piglets,bone,collagen,alpha-ketoglutarate},
  language     = {eng},
  number       = {2},
  pages        = {287--292},
  publisher    = {National Veterinary Research Institute},
  series       = {Bulletin of the Veterinary Institute in Puławy},
  title        = {Relation Between Growth And Bone Collagen Content In Young Pigs; Effects Of Dietary Alpha-Ketoglutarate Supplementation},
  volume       = {55},
  year         = {2011},
}