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Dietary factors and in situ and invasive cervical cancer risk in the European prospective investigation into cancer and nutrition study

Gonzalez, Carlos A.; Travier, Noemie; Lujan-Barroso, Leila; Castellsague, Xavier; Xavier Bosch, F.; Roura, Esther; Bueno-de-Mesquita, H. Bas; Palli, Domenico; Boeing, Heiner and Pala, Valeria, et al. (2011) In International Journal of Cancer 129(2). p.449-459
Abstract
Some dietary factors could be involved as cofactors in cervical carcinogenesis, but evidence is inconclusive. There are no data about the effect of fruits and vegetables intake (F&V) on cervical cancer from cohort studies. We examined the association between the intake of F&V and selected nutrients and the incidence of carcinoma in situ (CIS) and invasive squamous cervical cancer (ISC) in a prospective study of 299,649 women, participating in the European Prospective Investigation into Cancer and Nutrition study. Cox proportional hazard models were used to estimate adjusted hazard ratios (HRs) and 95% confidence intervals (95% CI). A calibration study was used to control measurement errors in the dietary questionnaire. After a mean... (More)
Some dietary factors could be involved as cofactors in cervical carcinogenesis, but evidence is inconclusive. There are no data about the effect of fruits and vegetables intake (F&V) on cervical cancer from cohort studies. We examined the association between the intake of F&V and selected nutrients and the incidence of carcinoma in situ (CIS) and invasive squamous cervical cancer (ISC) in a prospective study of 299,649 women, participating in the European Prospective Investigation into Cancer and Nutrition study. Cox proportional hazard models were used to estimate adjusted hazard ratios (HRs) and 95% confidence intervals (95% CI). A calibration study was used to control measurement errors in the dietary questionnaire. After a mean of 9 years of follow-up, 253 ISC and 817 CIS cases were diagnosed. In the calibrated model, we observed a statistically significant inverse association of ISC with a daily increase in intake of 100 g of total fruits (HR 0.83; 95% CI 0.72-0.98) and a statistically nonsignificant inverse association with a daily increase in intake of 100 g of total vegetables (HR 0.85: 95% CI 0.65-1.10). Statistically nonsignificant inverse associations were also observed for leafy vegetables, root vegetables, garlic and onions, citrus fruits, vitamin C, vitamin E and retinol for ISC. No association was found regarding beta-carotene, vitamin D and folic acid for ISC. None of the dietary factors examined was associated with CIS. Our study suggests a possible protective role of fruit intake and other dietary factors on ISC that need to be confirmed on a larger number of ISC cases. (Less)
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keywords
cervical cancer, cohort study, foods and nutrients intake
in
International Journal of Cancer
volume
129
issue
2
pages
449 - 459
publisher
John Wiley & Sons
external identifiers
  • wos:000291603900019
  • scopus:79961117212
ISSN
0020-7136
DOI
10.1002/ijc.25679
language
English
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45ddf41d-3712-4e1e-ab04-9b9da9d36218 (old id 2052616)
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2011-08-02 09:01:02
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2017-04-23 03:18:44
@article{45ddf41d-3712-4e1e-ab04-9b9da9d36218,
  abstract     = {Some dietary factors could be involved as cofactors in cervical carcinogenesis, but evidence is inconclusive. There are no data about the effect of fruits and vegetables intake (F&V) on cervical cancer from cohort studies. We examined the association between the intake of F&V and selected nutrients and the incidence of carcinoma in situ (CIS) and invasive squamous cervical cancer (ISC) in a prospective study of 299,649 women, participating in the European Prospective Investigation into Cancer and Nutrition study. Cox proportional hazard models were used to estimate adjusted hazard ratios (HRs) and 95% confidence intervals (95% CI). A calibration study was used to control measurement errors in the dietary questionnaire. After a mean of 9 years of follow-up, 253 ISC and 817 CIS cases were diagnosed. In the calibrated model, we observed a statistically significant inverse association of ISC with a daily increase in intake of 100 g of total fruits (HR 0.83; 95% CI 0.72-0.98) and a statistically nonsignificant inverse association with a daily increase in intake of 100 g of total vegetables (HR 0.85: 95% CI 0.65-1.10). Statistically nonsignificant inverse associations were also observed for leafy vegetables, root vegetables, garlic and onions, citrus fruits, vitamin C, vitamin E and retinol for ISC. No association was found regarding beta-carotene, vitamin D and folic acid for ISC. None of the dietary factors examined was associated with CIS. Our study suggests a possible protective role of fruit intake and other dietary factors on ISC that need to be confirmed on a larger number of ISC cases.},
  author       = {Gonzalez, Carlos A. and Travier, Noemie and Lujan-Barroso, Leila and Castellsague, Xavier and Xavier Bosch, F. and Roura, Esther and Bueno-de-Mesquita, H. Bas and Palli, Domenico and Boeing, Heiner and Pala, Valeria and Sacerdote, Carlotta and Tumino, Rosario and Panico, Salvatore and Manjer, Jonas and Dillner, Joakim and Hallmans, Goran and Kjellberg, Lennart and Sanchez, Maria-Jose and Altzibar, Jone M. and Barricarte, Aurelio and Navarro, Carmen and Rodriguez, Laudina and Allen, Naomi and Key, Timothy J. and Kaaks, Rudolf and Rohrmann, Sabine and Overvad, Kim and Olsen, Anja and Tjonneland, Anne and Munk, Christian and Kjaer, Susanne Kruger and Peeters, Petra H. M. and van Duijnhoven, Franzel J. B. and Clavel-Chapelon, Francoise and Boutron-Ruault, Marie-Christine and Trichopoulou, Antonia and Benetou, Vasiliki and Naska, Androniki and Lund, Eiliv and Engeset, Dagrun and Skeie, Guri and Franceschi, Silvia and Slimani, Nadia and Rinaldi, Sabina and Riboli, Elio},
  issn         = {0020-7136},
  keyword      = {cervical cancer,cohort study,foods and nutrients intake},
  language     = {eng},
  number       = {2},
  pages        = {449--459},
  publisher    = {John Wiley & Sons},
  series       = {International Journal of Cancer},
  title        = {Dietary factors and in situ and invasive cervical cancer risk in the European prospective investigation into cancer and nutrition study},
  url          = {http://dx.doi.org/10.1002/ijc.25679},
  volume       = {129},
  year         = {2011},
}