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Protocol and Methodology of the Stroke in Young Fabry Patients (sifap1) Study: A Prospective Multicenter European Study of 5,024 Young Stroke Patients Aged 18-55 Years

Rolfs, Arndt; Martus, Peter; Heuschmann, Peter U.; Grittner, Ulrike; Holzhausen, Martin; Tatlisumak, Turgut; Boettcher, Tobias; Fazekas, Franz; Enzinger, Christian and Ropele, Stefan, et al. (2011) In Cerebrovascular Diseases 31(3). p.253-262
Abstract
Background: Stroke in the young has not been thoroughly investigated with most previous studies based on a small number of patients from single centers. Furthermore, recent reports indicate that Fabry disease may be a significant cause for young stroke. The primary aim of our study was to determine the prevalence of Fabry disease in young stroke patients, while the secondary aim was to describe patterns of stroke in young patients. Methods: We initiated the Stroke in Young Fabry Patients (sifap1) study as a multinational prospective European study of stroke patients aged 18-55 years and collected a broad range of clinical, laboratory, and radiological data using stringent standardized methods. All patients were tested for Fabry disease and... (More)
Background: Stroke in the young has not been thoroughly investigated with most previous studies based on a small number of patients from single centers. Furthermore, recent reports indicate that Fabry disease may be a significant cause for young stroke. The primary aim of our study was to determine the prevalence of Fabry disease in young stroke patients, while the secondary aim was to describe patterns of stroke in young patients. Methods: We initiated the Stroke in Young Fabry Patients (sifap1) study as a multinational prospective European study of stroke patients aged 18-55 years and collected a broad range of clinical, laboratory, and radiological data using stringent standardized methods. All patients were tested for Fabry disease and blood was stored for future genetic testing. Results: We managed to enroll 5,024 eligible young stroke patients in 15 countries and 47 centers across Europe between April 2007 and January 2010. The median number of patients included per center was 98 with a range between 8 and 315. The average duration of patient recruitment per center was 22 months, ranging between 5 and 33 months. The database was closed in July 2010. This paper describes protocol and methodology of the sifap1 study. Conclusion: The sifap1 study included the largest series of young stroke patients so far and will allow for analyses on a large number of aspects of stroke in the young. Copyright (C) 2010 S. Karger AG, Basel (Less)
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Contribution to journal
publication status
published
subject
keywords
young patients, Stroke, Fabry disease, Multicenter epidemiological study
in
Cerebrovascular Diseases
volume
31
issue
3
pages
253 - 262
publisher
Karger
external identifiers
  • wos:000291816300007
  • scopus:78650235882
ISSN
1421-9786
DOI
10.1159/000322153
language
English
LU publication?
yes
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57c9b9e7-69eb-42ff-be25-3ead574239b1 (old id 2056749)
date added to LUP
2011-08-02 09:00:54
date last changed
2017-11-05 03:24:48
@article{57c9b9e7-69eb-42ff-be25-3ead574239b1,
  abstract     = {Background: Stroke in the young has not been thoroughly investigated with most previous studies based on a small number of patients from single centers. Furthermore, recent reports indicate that Fabry disease may be a significant cause for young stroke. The primary aim of our study was to determine the prevalence of Fabry disease in young stroke patients, while the secondary aim was to describe patterns of stroke in young patients. Methods: We initiated the Stroke in Young Fabry Patients (sifap1) study as a multinational prospective European study of stroke patients aged 18-55 years and collected a broad range of clinical, laboratory, and radiological data using stringent standardized methods. All patients were tested for Fabry disease and blood was stored for future genetic testing. Results: We managed to enroll 5,024 eligible young stroke patients in 15 countries and 47 centers across Europe between April 2007 and January 2010. The median number of patients included per center was 98 with a range between 8 and 315. The average duration of patient recruitment per center was 22 months, ranging between 5 and 33 months. The database was closed in July 2010. This paper describes protocol and methodology of the sifap1 study. Conclusion: The sifap1 study included the largest series of young stroke patients so far and will allow for analyses on a large number of aspects of stroke in the young. Copyright (C) 2010 S. Karger AG, Basel},
  author       = {Rolfs, Arndt and Martus, Peter and Heuschmann, Peter U. and Grittner, Ulrike and Holzhausen, Martin and Tatlisumak, Turgut and Boettcher, Tobias and Fazekas, Franz and Enzinger, Christian and Ropele, Stefan and Schmidt, Reinhold and Riess, Olaf and Norrving, Bo},
  issn         = {1421-9786},
  keyword      = {young patients,Stroke,Fabry disease,Multicenter epidemiological study},
  language     = {eng},
  number       = {3},
  pages        = {253--262},
  publisher    = {Karger},
  series       = {Cerebrovascular Diseases},
  title        = {Protocol and Methodology of the Stroke in Young Fabry Patients (sifap1) Study: A Prospective Multicenter European Study of 5,024 Young Stroke Patients Aged 18-55 Years},
  url          = {http://dx.doi.org/10.1159/000322153},
  volume       = {31},
  year         = {2011},
}