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Beneficial Effects of Hormone Replacement Therapy on Periodontitis are Vitamin D Associated.

Jönsson, Daniel LU ; Aggarwal, Prerna; Nilsson, Bengt-Olof LU and Demmer, Ryan T (2013) In Journal of Periodontology 84(8). p.1048-1057
Abstract
Background: Possible synergism between female sex hormones and vitamin D on periodontitis pathology has not been assessed. Here, we investigate effects of estrogen, progesterone and vitamin D on periodontitis in a population-based sample and use cell studies to explore mechanistic explanations of the population-based findings. Methods: The epidemiological analysis utilizes cross-sectional data from the continuous NHANES 2001-2004. The cross-sections include n=1,230 women aged 40-85 who received a periodontal examination, responded to questions regarding hormone replacement therapy (HRT) and provided a blood sample for serum vitamin D assessments. For mechanistic cell culture studies, human monocytes were cultured with or without LPS,... (More)
Background: Possible synergism between female sex hormones and vitamin D on periodontitis pathology has not been assessed. Here, we investigate effects of estrogen, progesterone and vitamin D on periodontitis in a population-based sample and use cell studies to explore mechanistic explanations of the population-based findings. Methods: The epidemiological analysis utilizes cross-sectional data from the continuous NHANES 2001-2004. The cross-sections include n=1,230 women aged 40-85 who received a periodontal examination, responded to questions regarding hormone replacement therapy (HRT) and provided a blood sample for serum vitamin D assessments. For mechanistic cell culture studies, human monocytes were cultured with or without LPS, estradiol, progesterone and/or 1,25-dihydroxyvitamin D3 and transcriptional activity of IL-6, IL-1β, BLC and RANTES was assessed. Results: HRT use (vs. none) was associated with higher attachment levels and more teeth only among vitamin D sufficient (>20 ng/ml) participants. The odds ratio for having moderate/severe periodontitis among HRT vs. non-HRT users was 0.69 among vitamin D sufficient participants and 1.19 in vitamin D deficient subjects. LPS-induced IL-6, IL-1β and BLC expression was attenuated in human monocytes treated with estrogen and progesterone. Down-regulation of IL-6 expression by estrogen and progesterone was potentiated when vitamin D was included. LPS-induced IL-6 and RANTES expression was decreased, and BLC expression was totally reversed, by vitamin D treatment. Conclusion: Maximal beneficial effects of HRT on periodontitis are associated with high vitamin D levels. This effect is plausibly mediated via an anti-inflammatory transcriptional mechanism. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Periodontology
volume
84
issue
8
pages
1048 - 1057
publisher
American Academy of Periodontology
external identifiers
  • wos:000328685100002
  • pmid:23030238
  • scopus:84882242816
ISSN
0022-3492
DOI
10.1902/jop.2012.120434
language
English
LU publication?
yes
id
2105c6e5-2aad-47c6-9d1d-158a5255a6e0 (old id 3161199)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/23030238?dopt=Abstract
date added to LUP
2012-11-01 13:07:12
date last changed
2019-02-20 02:01:32
@article{2105c6e5-2aad-47c6-9d1d-158a5255a6e0,
  abstract     = {Background: Possible synergism between female sex hormones and vitamin D on periodontitis pathology has not been assessed. Here, we investigate effects of estrogen, progesterone and vitamin D on periodontitis in a population-based sample and use cell studies to explore mechanistic explanations of the population-based findings. Methods: The epidemiological analysis utilizes cross-sectional data from the continuous NHANES 2001-2004. The cross-sections include n=1,230 women aged 40-85 who received a periodontal examination, responded to questions regarding hormone replacement therapy (HRT) and provided a blood sample for serum vitamin D assessments. For mechanistic cell culture studies, human monocytes were cultured with or without LPS, estradiol, progesterone and/or 1,25-dihydroxyvitamin D3 and transcriptional activity of IL-6, IL-1β, BLC and RANTES was assessed. Results: HRT use (vs. none) was associated with higher attachment levels and more teeth only among vitamin D sufficient (>20 ng/ml) participants. The odds ratio for having moderate/severe periodontitis among HRT vs. non-HRT users was 0.69 among vitamin D sufficient participants and 1.19 in vitamin D deficient subjects. LPS-induced IL-6, IL-1β and BLC expression was attenuated in human monocytes treated with estrogen and progesterone. Down-regulation of IL-6 expression by estrogen and progesterone was potentiated when vitamin D was included. LPS-induced IL-6 and RANTES expression was decreased, and BLC expression was totally reversed, by vitamin D treatment. Conclusion: Maximal beneficial effects of HRT on periodontitis are associated with high vitamin D levels. This effect is plausibly mediated via an anti-inflammatory transcriptional mechanism.},
  author       = {Jönsson, Daniel and Aggarwal, Prerna and Nilsson, Bengt-Olof and Demmer, Ryan T},
  issn         = {0022-3492},
  language     = {eng},
  number       = {8},
  pages        = {1048--1057},
  publisher    = {American Academy of Periodontology},
  series       = {Journal of Periodontology},
  title        = {Beneficial Effects of Hormone Replacement Therapy on Periodontitis are Vitamin D Associated.},
  url          = {http://dx.doi.org/10.1902/jop.2012.120434},
  volume       = {84},
  year         = {2013},
}