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Glucose-sensing mechanisms in pancreatic beta-cells

MacDonald, Patrick LU ; Joseph, JW and Rorsman, Patrik LU (2005) In Royal Society of London. Philosophical Transactions B. Biological Sciences 360(1464). p.2211-2225
Abstract
The appropriate secretion of insulin from pancreatic beta-cells is critically important to the maintenance of energy homeostasis. The beta-cells must sense and respond suitably to postprandial increases of blood glucose, and perturbation of glucose-sensing in these cells can lead to hypoglycaemia or hyperglycaemias and ultimately diabetes. Here, we review beta-cell glucose-sensing with a particular focus on the regulation of cellular excitability and exocytosis. We examine in turn: (i) the generation of metabolic signalling molecules; (ii) the regulation of beta-cell membrane potential; and (iii) insulin granule dynamics and exocytosis. We further discuss the role of well known and putative candidate metabolic signals as regulators of... (More)
The appropriate secretion of insulin from pancreatic beta-cells is critically important to the maintenance of energy homeostasis. The beta-cells must sense and respond suitably to postprandial increases of blood glucose, and perturbation of glucose-sensing in these cells can lead to hypoglycaemia or hyperglycaemias and ultimately diabetes. Here, we review beta-cell glucose-sensing with a particular focus on the regulation of cellular excitability and exocytosis. We examine in turn: (i) the generation of metabolic signalling molecules; (ii) the regulation of beta-cell membrane potential; and (iii) insulin granule dynamics and exocytosis. We further discuss the role of well known and putative candidate metabolic signals as regulators of insulin secretion. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
potential, membrane, ion channels, metabolism, glucose, insulin secretion, exocytosis
in
Royal Society of London. Philosophical Transactions B. Biological Sciences
volume
360
issue
1464
pages
2211 - 2225
publisher
Royal Society
external identifiers
  • pmid:16321791
  • wos:000233992100003
  • scopus:33244466564
ISSN
1471-2970
DOI
10.1098/rstb.2005.1762
language
English
LU publication?
yes
id
50c4202d-b2e4-429f-9836-eb0c54e86ed7 (old id 210871)
date added to LUP
2007-08-14 10:26:17
date last changed
2017-10-08 04:22:48
@article{50c4202d-b2e4-429f-9836-eb0c54e86ed7,
  abstract     = {The appropriate secretion of insulin from pancreatic beta-cells is critically important to the maintenance of energy homeostasis. The beta-cells must sense and respond suitably to postprandial increases of blood glucose, and perturbation of glucose-sensing in these cells can lead to hypoglycaemia or hyperglycaemias and ultimately diabetes. Here, we review beta-cell glucose-sensing with a particular focus on the regulation of cellular excitability and exocytosis. We examine in turn: (i) the generation of metabolic signalling molecules; (ii) the regulation of beta-cell membrane potential; and (iii) insulin granule dynamics and exocytosis. We further discuss the role of well known and putative candidate metabolic signals as regulators of insulin secretion.},
  author       = {MacDonald, Patrick and Joseph, JW and Rorsman, Patrik},
  issn         = {1471-2970},
  keyword      = {potential,membrane,ion channels,metabolism,glucose,insulin secretion,exocytosis},
  language     = {eng},
  number       = {1464},
  pages        = {2211--2225},
  publisher    = {Royal Society},
  series       = {Royal Society of London. Philosophical Transactions B. Biological Sciences},
  title        = {Glucose-sensing mechanisms in pancreatic beta-cells},
  url          = {http://dx.doi.org/10.1098/rstb.2005.1762},
  volume       = {360},
  year         = {2005},
}