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alpha-ketoglutarate (AKG) absorption from pig intestine and plasma pharmacokinetics

Dabek, M; Kruszewska, Danuta LU ; Filip, R; Hotowy, A; Pierzynowski, L; Wojtasz-Pajak, A; Szymanczyk, S; Piedra, J L V; Werpachowska, E and Pierzynowski, Stefan LU (2005) In Journal of Animal Physiology and Animal Nutrition 89(11-12). p.419-426
Abstract
To study the absorption, metabolism and kinetics, the AKG ( in different concentrations) was administered intravenously, intra-portally, orally and directly into the ileum or duodenum of pigs, chronically fitted with portal and jugular catheters and T-shaped cannula at the duodenum and ileum. Additionally, this study was conducted to determine the influence of low pH, Fe2+ or/ and SO42- on AKG gut absorption and conversely FeSO4 and FeSO4/AKG on Fe2+ gut absorption. It is concluded that AKG was significantly better absorbed from the upper small intestine than from the distal sections. Furthermore, low pH, Fe2+ and/or SO42- ions enhanced AKG absorption. The AKG administered to the portal vein was rapidly eliminated from the blood (half-life... (More)
To study the absorption, metabolism and kinetics, the AKG ( in different concentrations) was administered intravenously, intra-portally, orally and directly into the ileum or duodenum of pigs, chronically fitted with portal and jugular catheters and T-shaped cannula at the duodenum and ileum. Additionally, this study was conducted to determine the influence of low pH, Fe2+ or/ and SO42- on AKG gut absorption and conversely FeSO4 and FeSO4/AKG on Fe2+ gut absorption. It is concluded that AKG was significantly better absorbed from the upper small intestine than from the distal sections. Furthermore, low pH, Fe2+ and/or SO42- ions enhanced AKG absorption. The AKG administered to the portal vein was rapidly eliminated from the blood (half-life less than 5 min). The short lifetime for AKG is probably dependent on quick metabolism in the enteorcyetes and liver. However, the prolonged half-life can be related to its low AKG blood concentration. The Fe2+ concentrations in blood increased after FeSO4 and FeSO4/AKG duodenal infusion. The implication of above observations is important for practical application of the AKG in animal and human nutrition as well in medicine. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Animal Physiology and Animal Nutrition
volume
89
issue
11-12
pages
419 - 426
publisher
Wiley-Blackwell
external identifiers
  • pmid:16401194
  • wos:000233530100008
  • scopus:28944447958
ISSN
0931-2439
DOI
10.1111/j.1439-0396.2005.00566.x
language
English
LU publication?
yes
id
c1b9f243-8d11-4f9d-af73-df0b54c5f10d (old id 212164)
date added to LUP
2007-08-02 14:23:44
date last changed
2017-04-30 13:50:05
@article{c1b9f243-8d11-4f9d-af73-df0b54c5f10d,
  abstract     = {To study the absorption, metabolism and kinetics, the AKG ( in different concentrations) was administered intravenously, intra-portally, orally and directly into the ileum or duodenum of pigs, chronically fitted with portal and jugular catheters and T-shaped cannula at the duodenum and ileum. Additionally, this study was conducted to determine the influence of low pH, Fe2+ or/ and SO42- on AKG gut absorption and conversely FeSO4 and FeSO4/AKG on Fe2+ gut absorption. It is concluded that AKG was significantly better absorbed from the upper small intestine than from the distal sections. Furthermore, low pH, Fe2+ and/or SO42- ions enhanced AKG absorption. The AKG administered to the portal vein was rapidly eliminated from the blood (half-life less than 5 min). The short lifetime for AKG is probably dependent on quick metabolism in the enteorcyetes and liver. However, the prolonged half-life can be related to its low AKG blood concentration. The Fe2+ concentrations in blood increased after FeSO4 and FeSO4/AKG duodenal infusion. The implication of above observations is important for practical application of the AKG in animal and human nutrition as well in medicine.},
  author       = {Dabek, M and Kruszewska, Danuta and Filip, R and Hotowy, A and Pierzynowski, L and Wojtasz-Pajak, A and Szymanczyk, S and Piedra, J L V and Werpachowska, E and Pierzynowski, Stefan},
  issn         = {0931-2439},
  language     = {eng},
  number       = {11-12},
  pages        = {419--426},
  publisher    = {Wiley-Blackwell},
  series       = {Journal of Animal Physiology and Animal Nutrition},
  title        = {alpha-ketoglutarate (AKG) absorption from pig intestine and plasma pharmacokinetics},
  url          = {http://dx.doi.org/10.1111/j.1439-0396.2005.00566.x},
  volume       = {89},
  year         = {2005},
}