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The impact of type 2 diabetes mellitus on cancer-specific survival: A follow-up study in sweden.

Liu, Xiangdong LU ; Ji, Jianguang LU ; Sundquist, Kristina LU ; Sundquist, Jan LU and Hemminki, Kari LU (2012) In Cancer 118(5). p.1353-1361
Abstract
BACKGROUND:

Earlier studies have suggested that type 2 diabetes mellitus (T2DM) alters the risk of developing a variety of cancers, but little has been known about the impact of T2DM on cancer prognosis. On the basis of nationwide population-based Swedish registries, the authors of this report compared the cause-specific survival among cancer patients with and without T2DM.



METHODS:

Patients with T2DM were identified from the nationwide Swedish Hospital Discharge Register, and cancers were recorded from the Swedish Cancer Registry. Hazard ratios (HRs) were calculated using Cox regression models to compare variations in cause-specific survival between cancer patients with and without T2DM.

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BACKGROUND:

Earlier studies have suggested that type 2 diabetes mellitus (T2DM) alters the risk of developing a variety of cancers, but little has been known about the impact of T2DM on cancer prognosis. On the basis of nationwide population-based Swedish registries, the authors of this report compared the cause-specific survival among cancer patients with and without T2DM.



METHODS:

Patients with T2DM were identified from the nationwide Swedish Hospital Discharge Register, and cancers were recorded from the Swedish Cancer Registry. Hazard ratios (HRs) were calculated using Cox regression models to compare variations in cause-specific survival between cancer patients with and without T2DM.



RESULTS:

Of the 1016,105 cancer patients, 16,123 had been hospitalized with T2DM before their diagnosis of cancer. The mortality rate was significantly higher among cancer patients with T2DM than among those without T2DM (cause-specific HR, 1.38; 95% confidence interval, 1.35-1.41). There were no differences in TNM stage distribution among cancer patients with or without T2DM for the main cancers, with an exception of tumor and metastatic classifications for breast cancer and prostate cancer, respectively.



CONCLUSIONS:

The current results indicated that patients with T2DM who are diagnosed with a subsequent cancer are at an increased risk for cause-specific mortality compared with patients who have cancer without T2DM. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
diabetes mellitus, type 2, TNM classification, cancer-specific survival, national database
in
Cancer
volume
118
issue
5
pages
1353 - 1361
publisher
John Wiley & Sons
external identifiers
  • wos:000300667800023
  • pmid:21800292
  • scopus:84857370704
ISSN
1097-0142
DOI
10.1002/cncr.26420
language
English
LU publication?
yes
id
ceb78177-662b-4874-9e0c-9ff2d000a63a (old id 2151689)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/21800292?dopt=Abstract
date added to LUP
2011-09-04 21:02:38
date last changed
2017-05-28 03:16:25
@article{ceb78177-662b-4874-9e0c-9ff2d000a63a,
  abstract     = {BACKGROUND:<br/><br>
Earlier studies have suggested that type 2 diabetes mellitus (T2DM) alters the risk of developing a variety of cancers, but little has been known about the impact of T2DM on cancer prognosis. On the basis of nationwide population-based Swedish registries, the authors of this report compared the cause-specific survival among cancer patients with and without T2DM.<br/><br>
<br/><br>
METHODS:<br/><br>
Patients with T2DM were identified from the nationwide Swedish Hospital Discharge Register, and cancers were recorded from the Swedish Cancer Registry. Hazard ratios (HRs) were calculated using Cox regression models to compare variations in cause-specific survival between cancer patients with and without T2DM.<br/><br>
<br/><br>
RESULTS:<br/><br>
Of the 1016,105 cancer patients, 16,123 had been hospitalized with T2DM before their diagnosis of cancer. The mortality rate was significantly higher among cancer patients with T2DM than among those without T2DM (cause-specific HR, 1.38; 95% confidence interval, 1.35-1.41). There were no differences in TNM stage distribution among cancer patients with or without T2DM for the main cancers, with an exception of tumor and metastatic classifications for breast cancer and prostate cancer, respectively.<br/><br>
<br/><br>
CONCLUSIONS:<br/><br>
The current results indicated that patients with T2DM who are diagnosed with a subsequent cancer are at an increased risk for cause-specific mortality compared with patients who have cancer without T2DM.},
  author       = {Liu, Xiangdong and Ji, Jianguang and Sundquist, Kristina and Sundquist, Jan and Hemminki, Kari},
  issn         = {1097-0142},
  keyword      = {diabetes mellitus,type 2,TNM classification,cancer-specific survival,national database},
  language     = {eng},
  number       = {5},
  pages        = {1353--1361},
  publisher    = {John Wiley & Sons},
  series       = {Cancer},
  title        = {The impact of type 2 diabetes mellitus on cancer-specific survival: A follow-up study in sweden.},
  url          = {http://dx.doi.org/10.1002/cncr.26420},
  volume       = {118},
  year         = {2012},
}