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Clonal Evolution through Loss of Chromosomes and Subsequent Polyploidization in Chondrosarcoma.

Olsson, Linda LU ; Paulsson, Kajsa LU ; Bovée, Judith V M G and Hansén Nord, Karolin LU (2011) In PLoS ONE 6(9).
Abstract
Near-haploid chromosome numbers have been found in less than 1% of cytogenetically reported tumors, but seem to be more common in certain neoplasms including the malignant cartilage-producing tumor chondrosarcoma. By a literature survey of published karyotypes from chondrosarcomas we could confirm that loss of chromosomes resulting in hyperhaploid-hypodiploid cells is common and that these cells may polyploidize. Sixteen chondrosarcomas were investigated by single nucleotide polymorphism (SNP) array and the majority displayed SNP patterns indicative of a hyperhaploid-hypodiploid origin, with or without subsequent polyploidization. Except for chromosomes 5, 7, 19, 20 and 21, autosomal loss of heterozygosity was commonly found, resulting... (More)
Near-haploid chromosome numbers have been found in less than 1% of cytogenetically reported tumors, but seem to be more common in certain neoplasms including the malignant cartilage-producing tumor chondrosarcoma. By a literature survey of published karyotypes from chondrosarcomas we could confirm that loss of chromosomes resulting in hyperhaploid-hypodiploid cells is common and that these cells may polyploidize. Sixteen chondrosarcomas were investigated by single nucleotide polymorphism (SNP) array and the majority displayed SNP patterns indicative of a hyperhaploid-hypodiploid origin, with or without subsequent polyploidization. Except for chromosomes 5, 7, 19, 20 and 21, autosomal loss of heterozygosity was commonly found, resulting from chromosome loss and subsequent duplication of monosomic chromosomes giving rise to uniparental disomy. Additional gains, losses and rearrangements of genetic material, and even repeated rounds of polyploidization, may affect chondrosarcoma cells resulting in highly complex karyotypes. Loss of chromosomes and subsequent polyploidization was not restricted to a particular chondrosarcoma subtype and, although commonly found in chondrosarcoma, binucleated cells did not seem to be involved in these events. (Less)
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published
subject
in
PLoS ONE
volume
6
issue
9
publisher
Public Library of Science
external identifiers
  • wos:000295260400027
  • pmid:21949816
  • scopus:80052917970
ISSN
1932-6203
DOI
10.1371/journal.pone.0024977
language
English
LU publication?
yes
id
226d7315-f11d-4d55-98b2-74fb8689a6e6 (old id 2168394)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/21949816?dopt=Abstract
date added to LUP
2011-10-03 14:25:12
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2017-01-01 06:21:48
@article{226d7315-f11d-4d55-98b2-74fb8689a6e6,
  abstract     = {Near-haploid chromosome numbers have been found in less than 1% of cytogenetically reported tumors, but seem to be more common in certain neoplasms including the malignant cartilage-producing tumor chondrosarcoma. By a literature survey of published karyotypes from chondrosarcomas we could confirm that loss of chromosomes resulting in hyperhaploid-hypodiploid cells is common and that these cells may polyploidize. Sixteen chondrosarcomas were investigated by single nucleotide polymorphism (SNP) array and the majority displayed SNP patterns indicative of a hyperhaploid-hypodiploid origin, with or without subsequent polyploidization. Except for chromosomes 5, 7, 19, 20 and 21, autosomal loss of heterozygosity was commonly found, resulting from chromosome loss and subsequent duplication of monosomic chromosomes giving rise to uniparental disomy. Additional gains, losses and rearrangements of genetic material, and even repeated rounds of polyploidization, may affect chondrosarcoma cells resulting in highly complex karyotypes. Loss of chromosomes and subsequent polyploidization was not restricted to a particular chondrosarcoma subtype and, although commonly found in chondrosarcoma, binucleated cells did not seem to be involved in these events.},
  articleno    = {e24977},
  author       = {Olsson, Linda and Paulsson, Kajsa and Bovée, Judith V M G and Hansén Nord, Karolin},
  issn         = {1932-6203},
  language     = {eng},
  number       = {9},
  publisher    = {Public Library of Science},
  series       = {PLoS ONE},
  title        = {Clonal Evolution through Loss of Chromosomes and Subsequent Polyploidization in Chondrosarcoma.},
  url          = {http://dx.doi.org/10.1371/journal.pone.0024977},
  volume       = {6},
  year         = {2011},
}