Clonal Evolution through Loss of Chromosomes and Subsequent Polyploidization in Chondrosarcoma.
(2011) In PLoS ONE 6(9).- Abstract
- Near-haploid chromosome numbers have been found in less than 1% of cytogenetically reported tumors, but seem to be more common in certain neoplasms including the malignant cartilage-producing tumor chondrosarcoma. By a literature survey of published karyotypes from chondrosarcomas we could confirm that loss of chromosomes resulting in hyperhaploid-hypodiploid cells is common and that these cells may polyploidize. Sixteen chondrosarcomas were investigated by single nucleotide polymorphism (SNP) array and the majority displayed SNP patterns indicative of a hyperhaploid-hypodiploid origin, with or without subsequent polyploidization. Except for chromosomes 5, 7, 19, 20 and 21, autosomal loss of heterozygosity was commonly found, resulting... (More)
- Near-haploid chromosome numbers have been found in less than 1% of cytogenetically reported tumors, but seem to be more common in certain neoplasms including the malignant cartilage-producing tumor chondrosarcoma. By a literature survey of published karyotypes from chondrosarcomas we could confirm that loss of chromosomes resulting in hyperhaploid-hypodiploid cells is common and that these cells may polyploidize. Sixteen chondrosarcomas were investigated by single nucleotide polymorphism (SNP) array and the majority displayed SNP patterns indicative of a hyperhaploid-hypodiploid origin, with or without subsequent polyploidization. Except for chromosomes 5, 7, 19, 20 and 21, autosomal loss of heterozygosity was commonly found, resulting from chromosome loss and subsequent duplication of monosomic chromosomes giving rise to uniparental disomy. Additional gains, losses and rearrangements of genetic material, and even repeated rounds of polyploidization, may affect chondrosarcoma cells resulting in highly complex karyotypes. Loss of chromosomes and subsequent polyploidization was not restricted to a particular chondrosarcoma subtype and, although commonly found in chondrosarcoma, binucleated cells did not seem to be involved in these events. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/2168394
- author
- Olsson, Linda LU ; Paulsson, Kajsa LU ; Bovée, Judith V M G and Hansén Nord, Karolin LU
- organization
- publishing date
- 2011
- type
- Contribution to journal
- publication status
- published
- subject
- in
- PLoS ONE
- volume
- 6
- issue
- 9
- article number
- e24977
- publisher
- Public Library of Science (PLoS)
- external identifiers
-
- wos:000295260400027
- pmid:21949816
- scopus:80052917970
- pmid:21949816
- ISSN
- 1932-6203
- DOI
- 10.1371/journal.pone.0024977
- language
- English
- LU publication?
- yes
- id
- 226d7315-f11d-4d55-98b2-74fb8689a6e6 (old id 2168394)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/21949816?dopt=Abstract
- date added to LUP
- 2016-04-01 14:39:56
- date last changed
- 2022-04-14 19:01:22
@article{226d7315-f11d-4d55-98b2-74fb8689a6e6, abstract = {{Near-haploid chromosome numbers have been found in less than 1% of cytogenetically reported tumors, but seem to be more common in certain neoplasms including the malignant cartilage-producing tumor chondrosarcoma. By a literature survey of published karyotypes from chondrosarcomas we could confirm that loss of chromosomes resulting in hyperhaploid-hypodiploid cells is common and that these cells may polyploidize. Sixteen chondrosarcomas were investigated by single nucleotide polymorphism (SNP) array and the majority displayed SNP patterns indicative of a hyperhaploid-hypodiploid origin, with or without subsequent polyploidization. Except for chromosomes 5, 7, 19, 20 and 21, autosomal loss of heterozygosity was commonly found, resulting from chromosome loss and subsequent duplication of monosomic chromosomes giving rise to uniparental disomy. Additional gains, losses and rearrangements of genetic material, and even repeated rounds of polyploidization, may affect chondrosarcoma cells resulting in highly complex karyotypes. Loss of chromosomes and subsequent polyploidization was not restricted to a particular chondrosarcoma subtype and, although commonly found in chondrosarcoma, binucleated cells did not seem to be involved in these events.}}, author = {{Olsson, Linda and Paulsson, Kajsa and Bovée, Judith V M G and Hansén Nord, Karolin}}, issn = {{1932-6203}}, language = {{eng}}, number = {{9}}, publisher = {{Public Library of Science (PLoS)}}, series = {{PLoS ONE}}, title = {{Clonal Evolution through Loss of Chromosomes and Subsequent Polyploidization in Chondrosarcoma.}}, url = {{https://lup.lub.lu.se/search/files/4094377/2369958.pdf}}, doi = {{10.1371/journal.pone.0024977}}, volume = {{6}}, year = {{2011}}, }