Advanced

Neuroblastoma aggressiveness in relation to sympathetic neuronal differentiation stage.

Mohlin, Sofie LU ; Wigerup, Caroline LU and Påhlman, Sven LU (2011) In Seminars in Cancer Biology 21(4). p.276-282
Abstract
Neuroblastoma is a childhood malignancy of the sympathetic neuronal lineage. It is a rare disease, but since it is frequently diagnosed during infancy, neuroblastoma causes life-long medical follow up of those children that survive the disease. It was early recognized that a high tumor cell differentiation stage correlates to favorable clinical stage and positive clinical outcome. Today, highly differentiated tumors are surgically removed and not further treated. Cells of many established human neuroblastoma cell lines have the capacity to differentiate when stimulated properly, and these cell lines have been used as models for studying and understanding central concepts of tumor cell differentiation. One recent aspect of this issue is the... (More)
Neuroblastoma is a childhood malignancy of the sympathetic neuronal lineage. It is a rare disease, but since it is frequently diagnosed during infancy, neuroblastoma causes life-long medical follow up of those children that survive the disease. It was early recognized that a high tumor cell differentiation stage correlates to favorable clinical stage and positive clinical outcome. Today, highly differentiated tumors are surgically removed and not further treated. Cells of many established human neuroblastoma cell lines have the capacity to differentiate when stimulated properly, and these cell lines have been used as models for studying and understanding central concepts of tumor cell differentiation. One recent aspect of this issue is the observation that tumor cells can dedifferentiate and gain a stem cell-like phenotype during hypoxic conditions, which was first shown in neuroblastoma. Aberrant or blocked differentiation is a central aspect of neuroblastoma genesis. In this review we summarize known genetic and non-genetic events in neuroblastoma that might be coupled to an aberrant sympathetic neuronal differentiation and thereby indirectly influencing tumorigenesis and/or aggressive neuroblastoma behavior. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Seminars in Cancer Biology
volume
21
issue
4
pages
276 - 282
publisher
Academic Press
external identifiers
  • wos:000297444700008
  • pmid:21945591
  • scopus:80655146975
ISSN
1096-3650
DOI
10.1016/j.semcancer.2011.09.002
language
English
LU publication?
yes
id
6adb05ad-f742-4aa8-8c1f-ea4319326acb (old id 2168408)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/21945591?dopt=Abstract
date added to LUP
2011-10-03 14:16:34
date last changed
2017-11-05 04:13:19
@article{6adb05ad-f742-4aa8-8c1f-ea4319326acb,
  abstract     = {Neuroblastoma is a childhood malignancy of the sympathetic neuronal lineage. It is a rare disease, but since it is frequently diagnosed during infancy, neuroblastoma causes life-long medical follow up of those children that survive the disease. It was early recognized that a high tumor cell differentiation stage correlates to favorable clinical stage and positive clinical outcome. Today, highly differentiated tumors are surgically removed and not further treated. Cells of many established human neuroblastoma cell lines have the capacity to differentiate when stimulated properly, and these cell lines have been used as models for studying and understanding central concepts of tumor cell differentiation. One recent aspect of this issue is the observation that tumor cells can dedifferentiate and gain a stem cell-like phenotype during hypoxic conditions, which was first shown in neuroblastoma. Aberrant or blocked differentiation is a central aspect of neuroblastoma genesis. In this review we summarize known genetic and non-genetic events in neuroblastoma that might be coupled to an aberrant sympathetic neuronal differentiation and thereby indirectly influencing tumorigenesis and/or aggressive neuroblastoma behavior.},
  author       = {Mohlin, Sofie and Wigerup, Caroline and Påhlman, Sven},
  issn         = {1096-3650},
  language     = {eng},
  number       = {4},
  pages        = {276--282},
  publisher    = {Academic Press},
  series       = {Seminars in Cancer Biology},
  title        = {Neuroblastoma aggressiveness in relation to sympathetic neuronal differentiation stage.},
  url          = {http://dx.doi.org/10.1016/j.semcancer.2011.09.002},
  volume       = {21},
  year         = {2011},
}