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Ceylon cinnamon does not affect postprandial plasma glucose or insulin in subjects with impaired glucose tolerance.

Wickenberg, Jennie LU ; Lindstedt Ingemansson, Sandra LU ; Berntorp, Kerstin LU ; Nilsson, Jan LU and Hlebowicz, Joanna LU (2012) In British Journal of Nutrition 107(12). p.1845-1849
Abstract
Previous studies on healthy subjects have shown that the intake of 6 g Cinnamomum cassia reduces postprandial glucose and that the intake of 3 g C. cassia reduces insulin response, without affecting postprandial glucose concentrations. Coumarin, which may damage the liver, is present in C. cassia, but not in Cinnamomum zeylanicum. The aim of the present study was to study the effect of C. zeylanicum on postprandial concentrations of plasma glucose, insulin, glycaemic index (GI) and insulinaemic index (GII) in subjects with impaired glucose tolerance (IGT). A total of ten subjects with IGT were assessed in a crossover trial. A standard 75 g oral glucose tolerance test (OGTT) was administered together with placebo or C. zeylanicum capsules.... (More)
Previous studies on healthy subjects have shown that the intake of 6 g Cinnamomum cassia reduces postprandial glucose and that the intake of 3 g C. cassia reduces insulin response, without affecting postprandial glucose concentrations. Coumarin, which may damage the liver, is present in C. cassia, but not in Cinnamomum zeylanicum. The aim of the present study was to study the effect of C. zeylanicum on postprandial concentrations of plasma glucose, insulin, glycaemic index (GI) and insulinaemic index (GII) in subjects with impaired glucose tolerance (IGT). A total of ten subjects with IGT were assessed in a crossover trial. A standard 75 g oral glucose tolerance test (OGTT) was administered together with placebo or C. zeylanicum capsules. Finger-prick capillary blood samples were taken for glucose measurements and venous blood for insulin measurements, before and at 15, 30, 45, 60, 90, 120, 150 and 180 min after the start of the OGTT. The ingestion of 6 g C. zeylanicum had no significant effect on glucose level, insulin response, GI or GII. Ingestion of C. zeylanicum does not affect postprandial plasma glucose or insulin levels in human subjects. The Federal Institute for Risk Assessment in Europe has suggested the replacement of C. cassia by C. zeylanicum or the use of aqueous extracts of C. cassia to lower coumarin exposure. However, the positive effects seen with C. cassia in subjects with poor glycaemic control would then be lost. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Insulin, Glucose, Ceylon cinnamon, Impaired glucose tolerance
in
British Journal of Nutrition
volume
107
issue
12
pages
1845 - 1849
publisher
Cambridge University Press
external identifiers
  • wos:000306092400014
  • pmid:21929834
  • scopus:84862517949
ISSN
1475-2662
DOI
10.1017/S0007114511005113
language
English
LU publication?
yes
id
f5235a03-4465-41c9-9681-d5c5561273da (old id 2168772)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/21929834?dopt=Abstract
date added to LUP
2011-10-03 11:33:05
date last changed
2017-07-02 03:17:34
@article{f5235a03-4465-41c9-9681-d5c5561273da,
  abstract     = {Previous studies on healthy subjects have shown that the intake of 6 g Cinnamomum cassia reduces postprandial glucose and that the intake of 3 g C. cassia reduces insulin response, without affecting postprandial glucose concentrations. Coumarin, which may damage the liver, is present in C. cassia, but not in Cinnamomum zeylanicum. The aim of the present study was to study the effect of C. zeylanicum on postprandial concentrations of plasma glucose, insulin, glycaemic index (GI) and insulinaemic index (GII) in subjects with impaired glucose tolerance (IGT). A total of ten subjects with IGT were assessed in a crossover trial. A standard 75 g oral glucose tolerance test (OGTT) was administered together with placebo or C. zeylanicum capsules. Finger-prick capillary blood samples were taken for glucose measurements and venous blood for insulin measurements, before and at 15, 30, 45, 60, 90, 120, 150 and 180 min after the start of the OGTT. The ingestion of 6 g C. zeylanicum had no significant effect on glucose level, insulin response, GI or GII. Ingestion of C. zeylanicum does not affect postprandial plasma glucose or insulin levels in human subjects. The Federal Institute for Risk Assessment in Europe has suggested the replacement of C. cassia by C. zeylanicum or the use of aqueous extracts of C. cassia to lower coumarin exposure. However, the positive effects seen with C. cassia in subjects with poor glycaemic control would then be lost.},
  author       = {Wickenberg, Jennie and Lindstedt Ingemansson, Sandra and Berntorp, Kerstin and Nilsson, Jan and Hlebowicz, Joanna},
  issn         = {1475-2662},
  keyword      = {Insulin,Glucose,Ceylon cinnamon,Impaired glucose tolerance},
  language     = {eng},
  number       = {12},
  pages        = {1845--1849},
  publisher    = {Cambridge University Press},
  series       = {British Journal of Nutrition},
  title        = {Ceylon cinnamon does not affect postprandial plasma glucose or insulin in subjects with impaired glucose tolerance.},
  url          = {http://dx.doi.org/10.1017/S0007114511005113},
  volume       = {107},
  year         = {2012},
}