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Cancer stem cells in tumor heterogeneity.

Pietras, Alexander LU (2011) In Advances in Cancer Research 112. p.255-281
Abstract
Cancer cells within a given tumor were long regarded as a largely homogeneous group of cells originating from a common progenitor cell. However, it is increasingly appreciated that there is a considerable heterogeneity within tumors also on the tumor cell level. This heterogeneity extends to virtually all measurable properties of cancer cells, ranging from differentiation state, proliferation rate, migratory and invasive capacity to size, and therapeutic response. Such heterogeneity likely represents a major therapeutic hurdle, but the mechanisms underlying its emergence remain poorly understood and a controversial topic. The cancer stem cell model of tumor progression has gained increasing support during the past several years. In this... (More)
Cancer cells within a given tumor were long regarded as a largely homogeneous group of cells originating from a common progenitor cell. However, it is increasingly appreciated that there is a considerable heterogeneity within tumors also on the tumor cell level. This heterogeneity extends to virtually all measurable properties of cancer cells, ranging from differentiation state, proliferation rate, migratory and invasive capacity to size, and therapeutic response. Such heterogeneity likely represents a major therapeutic hurdle, but the mechanisms underlying its emergence remain poorly understood and a controversial topic. The cancer stem cell model of tumor progression has gained increasing support during the past several years. In this review, I will discuss some major implications of the cancer stem cell hypothesis on the origins of tumor heterogeneity, focusing both on heterogeneity within the tumor cells proper and on potential transdifferentiation of cancer stem cells into stromal and endothelial lineages, as well as on heterogeneity of the therapeutic response. Evidence for and against a direct and causal role of cancer stem cells in the emergence of tumor heterogeneity will be weighed and alternative explanations for apparently contradictory observations discussed. Finally, I will discuss the potential origins of cancer stem cells and the various implications of origin to the contribution to tumor heterogeneity, and outline some future directions. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Advances in Cancer Research
volume
112
pages
255 - 281
publisher
Elsevier
external identifiers
  • wos:000295818600009
  • pmid:21925307
  • scopus:80052974307
ISSN
0065-230X
DOI
10.1016/B978-0-12-387688-1.00009-0
language
English
LU publication?
yes
id
786ad5da-ca18-4a31-a927-642308cceca7 (old id 2168829)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/21925307?dopt=Abstract
date added to LUP
2011-10-03 11:17:15
date last changed
2017-10-01 04:00:00
@article{786ad5da-ca18-4a31-a927-642308cceca7,
  abstract     = {Cancer cells within a given tumor were long regarded as a largely homogeneous group of cells originating from a common progenitor cell. However, it is increasingly appreciated that there is a considerable heterogeneity within tumors also on the tumor cell level. This heterogeneity extends to virtually all measurable properties of cancer cells, ranging from differentiation state, proliferation rate, migratory and invasive capacity to size, and therapeutic response. Such heterogeneity likely represents a major therapeutic hurdle, but the mechanisms underlying its emergence remain poorly understood and a controversial topic. The cancer stem cell model of tumor progression has gained increasing support during the past several years. In this review, I will discuss some major implications of the cancer stem cell hypothesis on the origins of tumor heterogeneity, focusing both on heterogeneity within the tumor cells proper and on potential transdifferentiation of cancer stem cells into stromal and endothelial lineages, as well as on heterogeneity of the therapeutic response. Evidence for and against a direct and causal role of cancer stem cells in the emergence of tumor heterogeneity will be weighed and alternative explanations for apparently contradictory observations discussed. Finally, I will discuss the potential origins of cancer stem cells and the various implications of origin to the contribution to tumor heterogeneity, and outline some future directions.},
  author       = {Pietras, Alexander},
  issn         = {0065-230X},
  language     = {eng},
  pages        = {255--281},
  publisher    = {Elsevier},
  series       = {Advances in Cancer Research},
  title        = {Cancer stem cells in tumor heterogeneity.},
  url          = {http://dx.doi.org/10.1016/B978-0-12-387688-1.00009-0},
  volume       = {112},
  year         = {2011},
}