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Venous Thromboembolism Does Not Share Strong Familial Susceptibility with Ischemic Stroke: A Nationwide Family Study in Sweden.

Zöller, Bengt LU ; Li, Xinjun LU ; Ohlsson, Henrik LU ; Sundquist, Jan LU and Sundquist, Kristina LU (2011) In Circulation: Cardiovascular Genetics 4(5). p.484-490
Abstract
BACKGROUND: -Coagulation allelic variants associated with venous thromboembolism (VTE) have been suggested to be involved in the pathogenesis of ischemic stroke. This nationwide study aimed at determining whether VTE shares familial susceptibility with ischemic stroke. Method and Results-The Swedish Multigeneration Register of 0-75-year-old subjects was linked to the Swedish Hospital Discharge Register and the Cause of Death Register for the period 1987-2007. Odds ratios (OR), for VTE, and ischemic stroke were determined in two ways: odds of ischemic stroke in offspring whose parents had been diagnosed with VTE, and odds of VTE in offspring whose parents had been diagnosed with ischemic stroke. The analyses were repeated for siblings and... (More)
BACKGROUND: -Coagulation allelic variants associated with venous thromboembolism (VTE) have been suggested to be involved in the pathogenesis of ischemic stroke. This nationwide study aimed at determining whether VTE shares familial susceptibility with ischemic stroke. Method and Results-The Swedish Multigeneration Register of 0-75-year-old subjects was linked to the Swedish Hospital Discharge Register and the Cause of Death Register for the period 1987-2007. Odds ratios (OR), for VTE, and ischemic stroke were determined in two ways: odds of ischemic stroke in offspring whose parents had been diagnosed with VTE, and odds of VTE in offspring whose parents had been diagnosed with ischemic stroke. The analyses were repeated for siblings and spouses. Offspring of parents with VTE (n=25 929) were at increased risk for ischemic stroke (n=5595): OR 1.10 (95% CI 1.06-1.14). Siblings of probands with VTE (n=45 132) had no increased risk of ischemic stroke (n=1716): OR 1.05 (95% CI 1.00-1.11). Spouses of probands with VTE (n=24 106) were at increased risk for ischemic stroke (n=940): OR 1.18 (95% CI 1.10-1.27). The risks for VTE in relatives of probands with ischemic stroke were: OR 1.15, 95% CI 1.10-1.21 (offspring), OR 1.07, 95% CI 1.02-1.12 (siblings), and OR 1.21, 95% CI 1.11-1.32 (spouses). CONCLUSIONS: -Venous thromboembolism does not share strong familial susceptibility with ischemic stroke in the Swedish population. Moreover, familial non-genetic factors contribute to the observed weak familial associations. The present study suggests that it is unlikely that strong shared disease-causing mutations exist to a large extent in the Swedish population. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
genetics, risk factors, thrombosis, ischemic stroke, family history
in
Circulation: Cardiovascular Genetics
volume
4
issue
5
pages
484 - 490
publisher
American Heart Association
external identifiers
  • wos:000296529200008
  • pmid:21880672
  • scopus:82955173752
ISSN
1942-325X
DOI
10.1161/CIRCGENETICS.111.959882
language
English
LU publication?
yes
id
a83174dd-10e3-41f8-bcf5-9edbb17f99c7 (old id 2169255)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/21880672?dopt=Abstract
date added to LUP
2011-10-03 08:51:46
date last changed
2017-09-10 03:16:55
@article{a83174dd-10e3-41f8-bcf5-9edbb17f99c7,
  abstract     = {BACKGROUND: -Coagulation allelic variants associated with venous thromboembolism (VTE) have been suggested to be involved in the pathogenesis of ischemic stroke. This nationwide study aimed at determining whether VTE shares familial susceptibility with ischemic stroke. Method and Results-The Swedish Multigeneration Register of 0-75-year-old subjects was linked to the Swedish Hospital Discharge Register and the Cause of Death Register for the period 1987-2007. Odds ratios (OR), for VTE, and ischemic stroke were determined in two ways: odds of ischemic stroke in offspring whose parents had been diagnosed with VTE, and odds of VTE in offspring whose parents had been diagnosed with ischemic stroke. The analyses were repeated for siblings and spouses. Offspring of parents with VTE (n=25 929) were at increased risk for ischemic stroke (n=5595): OR 1.10 (95% CI 1.06-1.14). Siblings of probands with VTE (n=45 132) had no increased risk of ischemic stroke (n=1716): OR 1.05 (95% CI 1.00-1.11). Spouses of probands with VTE (n=24 106) were at increased risk for ischemic stroke (n=940): OR 1.18 (95% CI 1.10-1.27). The risks for VTE in relatives of probands with ischemic stroke were: OR 1.15, 95% CI 1.10-1.21 (offspring), OR 1.07, 95% CI 1.02-1.12 (siblings), and OR 1.21, 95% CI 1.11-1.32 (spouses). CONCLUSIONS: -Venous thromboembolism does not share strong familial susceptibility with ischemic stroke in the Swedish population. Moreover, familial non-genetic factors contribute to the observed weak familial associations. The present study suggests that it is unlikely that strong shared disease-causing mutations exist to a large extent in the Swedish population.},
  author       = {Zöller, Bengt and Li, Xinjun and Ohlsson, Henrik and Sundquist, Jan and Sundquist, Kristina},
  issn         = {1942-325X},
  keyword      = {genetics,risk factors,thrombosis,ischemic stroke,family history},
  language     = {eng},
  number       = {5},
  pages        = {484--490},
  publisher    = {American Heart Association},
  series       = {Circulation: Cardiovascular Genetics},
  title        = {Venous Thromboembolism Does Not Share Strong Familial Susceptibility with Ischemic Stroke: A Nationwide Family Study in Sweden.},
  url          = {http://dx.doi.org/10.1161/CIRCGENETICS.111.959882},
  volume       = {4},
  year         = {2011},
}