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Positive correlation between tumor necrosis factor (TNF)-alpha and cardiorespiratory fitness after six-months of regular aerobic exercise in Peruvian Amerindian women

Lindgärde, Folke LU ; Gottsäter, Anders LU and Ahrén, Bo LU (2011) In Revista Médica de Chile 139(8). p.998-1005
Abstract
Background: Adipose tissue is a source of inflammatory cytokines which may influence insulin action. Aim: To evaluate exercise effects on plasma (p)-levels of tumor necrosis factor (TNF)-alpha, and interleukin (IL)-6 in Peruvian Amerindian women. Material and Methods: After five years of observation during which p-glucose deteriorated and weight increased, 44 Peruvian Amerindian women aged 20-59 years took part in a 6-month exercise program. Plasma TNF-alpha and IL-6 had been measured 5 years earlier, and were reassessed before and after exercise, using ELISA kits. Cardiorespiratory fitness was derived from the results of the twelve minutes' walk and expressed as maximum oxygen uptake (VO2max). Results: After the training program,... (More)
Background: Adipose tissue is a source of inflammatory cytokines which may influence insulin action. Aim: To evaluate exercise effects on plasma (p)-levels of tumor necrosis factor (TNF)-alpha, and interleukin (IL)-6 in Peruvian Amerindian women. Material and Methods: After five years of observation during which p-glucose deteriorated and weight increased, 44 Peruvian Amerindian women aged 20-59 years took part in a 6-month exercise program. Plasma TNF-alpha and IL-6 had been measured 5 years earlier, and were reassessed before and after exercise, using ELISA kits. Cardiorespiratory fitness was derived from the results of the twelve minutes' walk and expressed as maximum oxygen uptake (VO2max). Results: After the training program, estimated VO2max increased from 18.55 +/- 3.79 to 20.91 +/- 4.61 mL kg(-1) min(-1) (p < 0.01) and p-TNF-alpha increased from 3.2 +/- 3.4 to 4.3 +/- 6.6 pg/mL (p = 0.03). There were reductions in p-glucose from 5.19 +/- 1.59 to 4.32 +/- 1.62 mmol/L (p <0.01) and in waist circumference (p=0.01). Weight, p-insulin, and IL-6 did not change. Levels of p-glucose and p-TNF-alpha observed after the training period were identical to values 5 years earlier. P-TNF-alpha was positively associated with estimated VO2max, prior to (r = .414, p < 0.01) as well as after (r = .362, p < 0.05) exercise, independently of adiposity P-IL-6 was associated with waist circumference but not with estimated VO2max. Conclusions: P-TNF-alpha correlated with estimated VO2max independently of adiposity. Beneficial effects of exercise on p-glucose were observed in spite of an increase in p-TNF-alpha. (Rev Med Chile 2011; 139: 998-1005). (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Adiposity, Exercise, Interleukin-6, Physical fitness, Tumor necrosis, factor-alpha
in
Revista Médica de Chile
volume
139
issue
8
pages
998 - 1005
publisher
Sociedad Médica de Santiago
external identifiers
  • wos:000295186900004
  • pmid:22218729
ISSN
0034-9887
language
English
LU publication?
yes
id
6256b75f-0924-4668-962b-eddea6dfe7eb (old id 2179782)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/22218729?dopt=Abstract
date added to LUP
2011-11-01 07:47:29
date last changed
2016-04-15 14:59:27
@article{6256b75f-0924-4668-962b-eddea6dfe7eb,
  abstract     = {Background: Adipose tissue is a source of inflammatory cytokines which may influence insulin action. Aim: To evaluate exercise effects on plasma (p)-levels of tumor necrosis factor (TNF)-alpha, and interleukin (IL)-6 in Peruvian Amerindian women. Material and Methods: After five years of observation during which p-glucose deteriorated and weight increased, 44 Peruvian Amerindian women aged 20-59 years took part in a 6-month exercise program. Plasma TNF-alpha and IL-6 had been measured 5 years earlier, and were reassessed before and after exercise, using ELISA kits. Cardiorespiratory fitness was derived from the results of the twelve minutes' walk and expressed as maximum oxygen uptake (VO2max). Results: After the training program, estimated VO2max increased from 18.55 +/- 3.79 to 20.91 +/- 4.61 mL kg(-1) min(-1) (p &lt; 0.01) and p-TNF-alpha increased from 3.2 +/- 3.4 to 4.3 +/- 6.6 pg/mL (p = 0.03). There were reductions in p-glucose from 5.19 +/- 1.59 to 4.32 +/- 1.62 mmol/L (p &lt;0.01) and in waist circumference (p=0.01). Weight, p-insulin, and IL-6 did not change. Levels of p-glucose and p-TNF-alpha observed after the training period were identical to values 5 years earlier. P-TNF-alpha was positively associated with estimated VO2max, prior to (r = .414, p &lt; 0.01) as well as after (r = .362, p &lt; 0.05) exercise, independently of adiposity P-IL-6 was associated with waist circumference but not with estimated VO2max. Conclusions: P-TNF-alpha correlated with estimated VO2max independently of adiposity. Beneficial effects of exercise on p-glucose were observed in spite of an increase in p-TNF-alpha. (Rev Med Chile 2011; 139: 998-1005).},
  author       = {Lindgärde, Folke and Gottsäter, Anders and Ahrén, Bo},
  issn         = {0034-9887},
  keyword      = {Adiposity,Exercise,Interleukin-6,Physical fitness,Tumor necrosis,factor-alpha},
  language     = {eng},
  number       = {8},
  pages        = {998--1005},
  publisher    = {Sociedad Médica de Santiago},
  series       = {Revista Médica de Chile},
  title        = {Positive correlation between tumor necrosis factor (TNF)-alpha and cardiorespiratory fitness after six-months of regular aerobic exercise in Peruvian Amerindian women},
  volume       = {139},
  year         = {2011},
}