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Risks of papillary and follicular thyroid cancer among immigrants to Sweden

Mousavi, Seyed Mohsen; Brandt, Andreas; Sundquist, Jan LU and Hemminki, Kari LU (2011) In International Journal of Cancer 129(9). p.2248-2255
Abstract
Previous studies have indicated that ionizing radiation, particularly during childhood, is the main established risk factor for thyroid cancer. History of benign nodules/adenoma, goiter, iodine deficiency or high-iodine intake might be other associated factors. We wanted to define the histology-specific thyroid cancer risk in the first-generation immigrants to Sweden. We used the 2010 update of the nation-wide Swedish Family-Cancer Database (>12 million individuals; 1.8 million immigrants; histology code in force since 1958) to calculate standardized incidence ratios (SIRs) for histology-specific thyroid cancer among immigrants compared to the native Swedes. The patient series covered 2,604 male and 6,406 female Swedes, and 247 and 863... (More)
Previous studies have indicated that ionizing radiation, particularly during childhood, is the main established risk factor for thyroid cancer. History of benign nodules/adenoma, goiter, iodine deficiency or high-iodine intake might be other associated factors. We wanted to define the histology-specific thyroid cancer risk in the first-generation immigrants to Sweden. We used the 2010 update of the nation-wide Swedish Family-Cancer Database (>12 million individuals; 1.8 million immigrants; histology code in force since 1958) to calculate standardized incidence ratios (SIRs) for histology-specific thyroid cancer among immigrants compared to the native Swedes. The patient series covered 2,604 male and 6,406 female Swedes, and 247 and 863 immigrants. The median age at immigration was 29 years, and the median age at thyroid cancer diagnosis was 46 years. Increased risks for female papillary carcinoma were observed for Finns (SIR = 1.63), former Yugoslavians (2.36), Russians (2.34), other East Europeans (2.14), Turks (3.16), Iranians (2.68), Iraqis (2.77), East and Southeast Asians (2.92), other Asians (1.69) and South Americans (2.23). Male Iranians (2.85), East and Southeast Asians (3.57) and other Asians (2.26) had an increased risk for papillary carcinoma. Only male East and Southeast Asians (2.93) had an increased risk for follicular carcinoma. The data might suggest that immigrant populations in Sweden from areas of low or high-iodine intake are at risk of papillary carcinoma, implicating iodine imbalance as a contributing factor to our findings. The increased risk of thyroid cancer among Asian immigrants may confirm the role of childhood-ionizing radiation on thyroid cancer risk. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
follicular carcinoma, iodine salt, papillary carcinoma, risk, thyroid, cancer
in
International Journal of Cancer
volume
129
issue
9
pages
2248 - 2255
publisher
John Wiley & Sons
external identifiers
  • wos:000295230500019
  • scopus:80052196818
ISSN
0020-7136
DOI
10.1002/ijc.25867
language
English
LU publication?
yes
id
47cf4c25-b849-4acf-8276-7cad9a8baf01 (old id 2179888)
date added to LUP
2011-11-01 07:47:59
date last changed
2017-01-01 04:11:10
@article{47cf4c25-b849-4acf-8276-7cad9a8baf01,
  abstract     = {Previous studies have indicated that ionizing radiation, particularly during childhood, is the main established risk factor for thyroid cancer. History of benign nodules/adenoma, goiter, iodine deficiency or high-iodine intake might be other associated factors. We wanted to define the histology-specific thyroid cancer risk in the first-generation immigrants to Sweden. We used the 2010 update of the nation-wide Swedish Family-Cancer Database (>12 million individuals; 1.8 million immigrants; histology code in force since 1958) to calculate standardized incidence ratios (SIRs) for histology-specific thyroid cancer among immigrants compared to the native Swedes. The patient series covered 2,604 male and 6,406 female Swedes, and 247 and 863 immigrants. The median age at immigration was 29 years, and the median age at thyroid cancer diagnosis was 46 years. Increased risks for female papillary carcinoma were observed for Finns (SIR = 1.63), former Yugoslavians (2.36), Russians (2.34), other East Europeans (2.14), Turks (3.16), Iranians (2.68), Iraqis (2.77), East and Southeast Asians (2.92), other Asians (1.69) and South Americans (2.23). Male Iranians (2.85), East and Southeast Asians (3.57) and other Asians (2.26) had an increased risk for papillary carcinoma. Only male East and Southeast Asians (2.93) had an increased risk for follicular carcinoma. The data might suggest that immigrant populations in Sweden from areas of low or high-iodine intake are at risk of papillary carcinoma, implicating iodine imbalance as a contributing factor to our findings. The increased risk of thyroid cancer among Asian immigrants may confirm the role of childhood-ionizing radiation on thyroid cancer risk.},
  author       = {Mousavi, Seyed Mohsen and Brandt, Andreas and Sundquist, Jan and Hemminki, Kari},
  issn         = {0020-7136},
  keyword      = {follicular carcinoma,iodine salt,papillary carcinoma,risk,thyroid,cancer},
  language     = {eng},
  number       = {9},
  pages        = {2248--2255},
  publisher    = {John Wiley & Sons},
  series       = {International Journal of Cancer},
  title        = {Risks of papillary and follicular thyroid cancer among immigrants to Sweden},
  url          = {http://dx.doi.org/10.1002/ijc.25867},
  volume       = {129},
  year         = {2011},
}