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Factors affecting obstetric outcome of singletons born after IVF

Sazonova, Antonina; Källén, Karin LU ; Thurin-Kjellberg, Ann; Wennerholm, Ulla-Britt and Bergh, Christina (2011) In Human Reproduction 26(10). p.2878-2886
Abstract
BACKGROUND: Singletons born after IVF have an adverse perinatal outcome when compared with singletons in the general population. This study investigates maternal characteristics and IVF-treatment-related variables, for a possible influence on obstetric outcomes. METHODS: Data from all IVF clinics in Sweden, including all IVF singletons born after fresh treatment cycles and own oocytes during 2002-2006, were included (n = 8941) and cross-linked with the Swedish Medical Birth Registry. Four major outcomes were investigated: very preterm birth (<32 weeks), small for gestational age (SGA), placenta previa and placental abruption. Maternal characteristics (age, parity, BMI, smoking and years of infertility) and treatment-related variables... (More)
BACKGROUND: Singletons born after IVF have an adverse perinatal outcome when compared with singletons in the general population. This study investigates maternal characteristics and IVF-treatment-related variables, for a possible influence on obstetric outcomes. METHODS: Data from all IVF clinics in Sweden, including all IVF singletons born after fresh treatment cycles and own oocytes during 2002-2006, were included (n = 8941) and cross-linked with the Swedish Medical Birth Registry. Four major outcomes were investigated: very preterm birth (<32 weeks), small for gestational age (SGA), placenta previa and placental abruption. Maternal characteristics (age, parity, BMI, smoking and years of infertility) and treatment-related variables (number of oocytes retrieved, number of embryo culture days, number of transferred and cryopreserved embryos, 'vanishing twin') were investigated for independent association with the four selected outcomes. Adjusted odds ratios (AORs) were calculated by logistic regression. RESULTS: Primiparity, smoking, BMI and 'vanishing twin' were associated with an increased risk of very preterm birth. Maternal age, primiparity, smoking, BMI and years of infertility were associated with an increased risk of SGA. Maternal age and blastocyst transfer were associated with an increased risk, and primiparity with a decreased risk, of placenta previa. Smoking was significantly associated with placental abruption. CONCLUSIONS: In singletons born after fresh IVF, certain maternal characteristics and the number of embryos transferred, when there was a 'vanishing twin' affected the obstetric outcome negatively. An increased rate of placenta previa was observed after blastocyst transfer. The results support the use of single embryo transfer and indicate that lifestyle factors are important for obstetric outcome. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
IVF, single embryo transfer, children outcome, obstetric outcome
in
Human Reproduction
volume
26
issue
10
pages
2878 - 2886
publisher
Oxford University Press
external identifiers
  • wos:000294969500035
  • scopus:80052873345
ISSN
0268-1161
DOI
10.1093/humrep/der241
language
English
LU publication?
yes
id
fb256cd8-5e5a-485c-9b4f-e541030258ae (old id 2180182)
date added to LUP
2011-11-01 07:49:18
date last changed
2017-08-20 03:10:37
@article{fb256cd8-5e5a-485c-9b4f-e541030258ae,
  abstract     = {BACKGROUND: Singletons born after IVF have an adverse perinatal outcome when compared with singletons in the general population. This study investigates maternal characteristics and IVF-treatment-related variables, for a possible influence on obstetric outcomes. METHODS: Data from all IVF clinics in Sweden, including all IVF singletons born after fresh treatment cycles and own oocytes during 2002-2006, were included (n = 8941) and cross-linked with the Swedish Medical Birth Registry. Four major outcomes were investigated: very preterm birth (&lt;32 weeks), small for gestational age (SGA), placenta previa and placental abruption. Maternal characteristics (age, parity, BMI, smoking and years of infertility) and treatment-related variables (number of oocytes retrieved, number of embryo culture days, number of transferred and cryopreserved embryos, 'vanishing twin') were investigated for independent association with the four selected outcomes. Adjusted odds ratios (AORs) were calculated by logistic regression. RESULTS: Primiparity, smoking, BMI and 'vanishing twin' were associated with an increased risk of very preterm birth. Maternal age, primiparity, smoking, BMI and years of infertility were associated with an increased risk of SGA. Maternal age and blastocyst transfer were associated with an increased risk, and primiparity with a decreased risk, of placenta previa. Smoking was significantly associated with placental abruption. CONCLUSIONS: In singletons born after fresh IVF, certain maternal characteristics and the number of embryos transferred, when there was a 'vanishing twin' affected the obstetric outcome negatively. An increased rate of placenta previa was observed after blastocyst transfer. The results support the use of single embryo transfer and indicate that lifestyle factors are important for obstetric outcome.},
  author       = {Sazonova, Antonina and Källén, Karin and Thurin-Kjellberg, Ann and Wennerholm, Ulla-Britt and Bergh, Christina},
  issn         = {0268-1161},
  keyword      = {IVF,single embryo transfer,children outcome,obstetric outcome},
  language     = {eng},
  number       = {10},
  pages        = {2878--2886},
  publisher    = {Oxford University Press},
  series       = {Human Reproduction},
  title        = {Factors affecting obstetric outcome of singletons born after IVF},
  url          = {http://dx.doi.org/10.1093/humrep/der241},
  volume       = {26},
  year         = {2011},
}