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Computational Perspectives on Neuromodulation of Aging

Sikström, Sverker LU (2007) In Acta Neurochirurgica. Supplementum 97. p.513-518
Abstract
Cognitive functions, such as memory, attention, and perception, declines with age. Besides other neuroanatomical changes, the level of dopamine also attenuates during aging. We review how computational modeling can provide insights in how these lifetime changes in dopamine levels is expressed at the behavioral level yielding a bridge across different levels. Results indicate that attenuation of dopamine lowers the signal to noise ratio providing a less distinctive neural representation, and detrimental cognitive performance.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
cognitive functions, neural networks, aging, neuromodulation, Dopamine, noise
in
Acta Neurochirurgica. Supplementum
volume
97
pages
513 - 518
publisher
Springer
external identifiers
  • wos:000274732500059
  • scopus:34648822992
ISSN
0065-1419
DOI
10.1007/978-3-211-33081-4
language
English
LU publication?
yes
id
e4adbfd7-9a97-4e32-99d3-0dedab78b474 (old id 2199964)
date added to LUP
2011-10-31 13:54:47
date last changed
2017-01-01 06:57:12
@article{e4adbfd7-9a97-4e32-99d3-0dedab78b474,
  abstract     = {Cognitive functions, such as memory, attention, and perception, declines with age. Besides other neuroanatomical changes, the level of dopamine also attenuates during aging. We review how computational modeling can provide insights in how these lifetime changes in dopamine levels is expressed at the behavioral level yielding a bridge across different levels. Results indicate that attenuation of dopamine lowers the signal to noise ratio providing a less distinctive neural representation, and detrimental cognitive performance.},
  author       = {Sikström, Sverker},
  issn         = {0065-1419},
  keyword      = {cognitive functions,neural networks,aging,neuromodulation,Dopamine,noise},
  language     = {eng},
  pages        = {513--518},
  publisher    = {Springer},
  series       = {Acta Neurochirurgica. Supplementum},
  title        = {Computational Perspectives on Neuromodulation of Aging},
  url          = {http://dx.doi.org/10.1007/978-3-211-33081-4},
  volume       = {97},
  year         = {2007},
}