LIM-only protein Lmo2 forms a protein complex with erythroid transcription factor GATA-1
(1997) In Leukemia 11(Suppl 3). p.12-307- Abstract
The LIM-only protein Lmo2, originally identified as an oncogenic protein in human T cell leukemia, is essential for erythropoiesis. A possible role for Lmo2 in transcription during erythropoiesis has been investigated. Direct interaction of Lmo2 was observed in vitro and in vivo with the zinc finger transcription factor GATA-1, as well as with the basic helix-loop-helix (bHLH) transcription factor Tall. By using mammalian two-hybrid analysis, E47/Tall/Lmo2/GATA-1 protein complex could be demonstrated. Thus, a molecular link exists between three proteins crucial for erythropoiesis. This data suggest that variations in amounts of complexes involving Lmo2, Tall, and GATA-1 could be important for erythroid differentiation.
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https://lup.lub.lu.se/record/21f613e4-c250-4888-9935-95b13080bcc9
- author
- Osada, H ; Grutz, G G ; Axelson, H LU ; Forster, A and Rabbitts, T H
- organization
- publishing date
- 1997-04
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Adaptor Proteins, Signal Transducing, Animals, Basic Helix-Loop-Helix Transcription Factors, COS Cells, DNA-Binding Proteins, Erythroid-Specific DNA-Binding Factors, Erythropoiesis, GATA1 Transcription Factor, Helix-Loop-Helix Motifs, Humans, LIM Domain Proteins, Leukemia, Erythroblastic, Acute, Leukemia, T-Cell, Metalloproteins, Proto-Oncogene Proteins, Recombinant Proteins, Transcription Factors, Transcription, Genetic, Transfection, Tumor Cells, Cultured, Zinc Fingers
- in
- Leukemia
- volume
- 11
- issue
- Suppl 3
- pages
- 6 pages
- publisher
- Nature Publishing Group
- external identifiers
-
- scopus:0030824801
- pmid:9209374
- ISSN
- 0887-6924
- language
- English
- LU publication?
- yes
- id
- 21f613e4-c250-4888-9935-95b13080bcc9
- date added to LUP
- 2016-08-09 09:13:27
- date last changed
- 2024-01-04 10:35:44
@article{21f613e4-c250-4888-9935-95b13080bcc9, abstract = {{<p>The LIM-only protein Lmo2, originally identified as an oncogenic protein in human T cell leukemia, is essential for erythropoiesis. A possible role for Lmo2 in transcription during erythropoiesis has been investigated. Direct interaction of Lmo2 was observed in vitro and in vivo with the zinc finger transcription factor GATA-1, as well as with the basic helix-loop-helix (bHLH) transcription factor Tall. By using mammalian two-hybrid analysis, E47/Tall/Lmo2/GATA-1 protein complex could be demonstrated. Thus, a molecular link exists between three proteins crucial for erythropoiesis. This data suggest that variations in amounts of complexes involving Lmo2, Tall, and GATA-1 could be important for erythroid differentiation.</p>}}, author = {{Osada, H and Grutz, G G and Axelson, H and Forster, A and Rabbitts, T H}}, issn = {{0887-6924}}, keywords = {{Adaptor Proteins, Signal Transducing; Animals; Basic Helix-Loop-Helix Transcription Factors; COS Cells; DNA-Binding Proteins; Erythroid-Specific DNA-Binding Factors; Erythropoiesis; GATA1 Transcription Factor; Helix-Loop-Helix Motifs; Humans; LIM Domain Proteins; Leukemia, Erythroblastic, Acute; Leukemia, T-Cell; Metalloproteins; Proto-Oncogene Proteins; Recombinant Proteins; Transcription Factors; Transcription, Genetic; Transfection; Tumor Cells, Cultured; Zinc Fingers}}, language = {{eng}}, number = {{Suppl 3}}, pages = {{12--307}}, publisher = {{Nature Publishing Group}}, series = {{Leukemia}}, title = {{LIM-only protein Lmo2 forms a protein complex with erythroid transcription factor GATA-1}}, volume = {{11}}, year = {{1997}}, }