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LIM-only protein Lmo2 forms a protein complex with erythroid transcription factor GATA-1

Osada, H ; Grutz, G G ; Axelson, H LU ; Forster, A and Rabbitts, T H (1997) In Leukemia 11(Suppl 3). p.12-307
Abstract

The LIM-only protein Lmo2, originally identified as an oncogenic protein in human T cell leukemia, is essential for erythropoiesis. A possible role for Lmo2 in transcription during erythropoiesis has been investigated. Direct interaction of Lmo2 was observed in vitro and in vivo with the zinc finger transcription factor GATA-1, as well as with the basic helix-loop-helix (bHLH) transcription factor Tall. By using mammalian two-hybrid analysis, E47/Tall/Lmo2/GATA-1 protein complex could be demonstrated. Thus, a molecular link exists between three proteins crucial for erythropoiesis. This data suggest that variations in amounts of complexes involving Lmo2, Tall, and GATA-1 could be important for erythroid differentiation.

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author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Adaptor Proteins, Signal Transducing, Animals, Basic Helix-Loop-Helix Transcription Factors, COS Cells, DNA-Binding Proteins, Erythroid-Specific DNA-Binding Factors, Erythropoiesis, GATA1 Transcription Factor, Helix-Loop-Helix Motifs, Humans, LIM Domain Proteins, Leukemia, Erythroblastic, Acute, Leukemia, T-Cell, Metalloproteins, Proto-Oncogene Proteins, Recombinant Proteins, Transcription Factors, Transcription, Genetic, Transfection, Tumor Cells, Cultured, Zinc Fingers
in
Leukemia
volume
11
issue
Suppl 3
pages
6 pages
publisher
Nature Publishing Group
external identifiers
  • scopus:0030824801
  • pmid:9209374
ISSN
0887-6924
language
English
LU publication?
yes
id
21f613e4-c250-4888-9935-95b13080bcc9
date added to LUP
2016-08-09 09:13:27
date last changed
2024-01-04 10:35:44
@article{21f613e4-c250-4888-9935-95b13080bcc9,
  abstract     = {{<p>The LIM-only protein Lmo2, originally identified as an oncogenic protein in human T cell leukemia, is essential for erythropoiesis. A possible role for Lmo2 in transcription during erythropoiesis has been investigated. Direct interaction of Lmo2 was observed in vitro and in vivo with the zinc finger transcription factor GATA-1, as well as with the basic helix-loop-helix (bHLH) transcription factor Tall. By using mammalian two-hybrid analysis, E47/Tall/Lmo2/GATA-1 protein complex could be demonstrated. Thus, a molecular link exists between three proteins crucial for erythropoiesis. This data suggest that variations in amounts of complexes involving Lmo2, Tall, and GATA-1 could be important for erythroid differentiation.</p>}},
  author       = {{Osada, H and Grutz, G G and Axelson, H and Forster, A and Rabbitts, T H}},
  issn         = {{0887-6924}},
  keywords     = {{Adaptor Proteins, Signal Transducing; Animals; Basic Helix-Loop-Helix Transcription Factors; COS Cells; DNA-Binding Proteins; Erythroid-Specific DNA-Binding Factors; Erythropoiesis; GATA1 Transcription Factor; Helix-Loop-Helix Motifs; Humans; LIM Domain Proteins; Leukemia, Erythroblastic, Acute; Leukemia, T-Cell; Metalloproteins; Proto-Oncogene Proteins; Recombinant Proteins; Transcription Factors; Transcription, Genetic; Transfection; Tumor Cells, Cultured; Zinc Fingers}},
  language     = {{eng}},
  number       = {{Suppl 3}},
  pages        = {{12--307}},
  publisher    = {{Nature Publishing Group}},
  series       = {{Leukemia}},
  title        = {{LIM-only protein Lmo2 forms a protein complex with erythroid transcription factor GATA-1}},
  volume       = {{11}},
  year         = {{1997}},
}