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Light-activated channels in acute seizures.

Kokaia, Merab LU (2011) In Epilepsia 52 Suppl 8. p.16-18
Abstract
Optogenetics allow for timely precise and cell-population specific activation or inhibition of neuronal activity. Hallorhodopsin NpHR is an inward cholride pump, which when activated by orange light, hyperpolarises neuronal membrane and inhibitis action potential generation. We were first to show that transduction of principal neurons with NpHR in organotypic hippocampal slice cultures effectivey attenuates epileptiform activity when exposed to orange light. Our data suggest that optogenetic approach may become a useful method for controlling epileptiform activity, and may open novel avenues to develop alternative treatment strategies for epilepsy.
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Epilepsia
volume
52 Suppl 8
pages
16 - 18
publisher
Wiley-Blackwell
external identifiers
  • wos:000296065200006
  • pmid:21967352
  • scopus:80053581286
ISSN
0013-9580
DOI
10.1111/j.1528-1167.2011.03226.x
language
English
LU publication?
yes
id
65f8fad0-8d5a-418f-b1ec-1777503591da (old id 2200581)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/21967352?dopt=Abstract
date added to LUP
2011-11-02 10:03:31
date last changed
2017-01-01 07:34:56
@article{65f8fad0-8d5a-418f-b1ec-1777503591da,
  abstract     = {Optogenetics allow for timely precise and cell-population specific activation or inhibition of neuronal activity. Hallorhodopsin NpHR is an inward cholride pump, which when activated by orange light, hyperpolarises neuronal membrane and inhibitis action potential generation. We were first to show that transduction of principal neurons with NpHR in organotypic hippocampal slice cultures effectivey attenuates epileptiform activity when exposed to orange light. Our data suggest that optogenetic approach may become a useful method for controlling epileptiform activity, and may open novel avenues to develop alternative treatment strategies for epilepsy.},
  author       = {Kokaia, Merab},
  issn         = {0013-9580},
  language     = {eng},
  pages        = {16--18},
  publisher    = {Wiley-Blackwell},
  series       = {Epilepsia},
  title        = {Light-activated channels in acute seizures.},
  url          = {http://dx.doi.org/10.1111/j.1528-1167.2011.03226.x},
  volume       = {52 Suppl 8},
  year         = {2011},
}