Light-activated channels in acute seizures.
(2011) In Epilepsia 52 Suppl 8. p.16-18- Abstract
- Optogenetics allow for timely precise and cell-population specific activation or inhibition of neuronal activity. Hallorhodopsin NpHR is an inward cholride pump, which when activated by orange light, hyperpolarises neuronal membrane and inhibitis action potential generation. We were first to show that transduction of principal neurons with NpHR in organotypic hippocampal slice cultures effectivey attenuates epileptiform activity when exposed to orange light. Our data suggest that optogenetic approach may become a useful method for controlling epileptiform activity, and may open novel avenues to develop alternative treatment strategies for epilepsy.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/2200581
- author
- Kokaia, Merab LU
- organization
- publishing date
- 2011
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Epilepsia
- volume
- 52 Suppl 8
- pages
- 16 - 18
- publisher
- Wiley-Blackwell
- external identifiers
-
- wos:000296065200006
- pmid:21967352
- scopus:80053581286
- pmid:21967352
- ISSN
- 0013-9580
- DOI
- 10.1111/j.1528-1167.2011.03226.x
- language
- English
- LU publication?
- yes
- id
- 65f8fad0-8d5a-418f-b1ec-1777503591da (old id 2200581)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/21967352?dopt=Abstract
- date added to LUP
- 2016-04-04 08:05:24
- date last changed
- 2022-01-29 02:59:54
@article{65f8fad0-8d5a-418f-b1ec-1777503591da,
abstract = {{Optogenetics allow for timely precise and cell-population specific activation or inhibition of neuronal activity. Hallorhodopsin NpHR is an inward cholride pump, which when activated by orange light, hyperpolarises neuronal membrane and inhibitis action potential generation. We were first to show that transduction of principal neurons with NpHR in organotypic hippocampal slice cultures effectivey attenuates epileptiform activity when exposed to orange light. Our data suggest that optogenetic approach may become a useful method for controlling epileptiform activity, and may open novel avenues to develop alternative treatment strategies for epilepsy.}},
author = {{Kokaia, Merab}},
issn = {{0013-9580}},
language = {{eng}},
pages = {{16--18}},
publisher = {{Wiley-Blackwell}},
series = {{Epilepsia}},
title = {{Light-activated channels in acute seizures.}},
url = {{http://dx.doi.org/10.1111/j.1528-1167.2011.03226.x}},
doi = {{10.1111/j.1528-1167.2011.03226.x}},
volume = {{52 Suppl 8}},
year = {{2011}},
}