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Early menopause is an independent predictor of rheumatoid arthritis.

Pikwer, Mitra LU ; Bergström, Ulf LU ; Nilsson, Jan-Åke LU ; Jacobsson, Lennart LU and Turesson, Carl LU (2012) In Annals of the Rheumatic Diseases 71. p.378-381
Abstract
BACKGROUND: As rheumatoid arthritis (RA) occurs more often in women than in men, it has been suggested that reproductive hormones may play an important role in the pathogenesis.METHODS: Between 1991 and 1996, 30 447 subjects (18 326 women) were included in a community-based health survey. Information on female hormonal changes and stress-related factors was obtained using a self-administered questionnaire. This population was linked to four different local and national RA registers. The medical records for patients with a diagnosis of RA were subjected to a structured review and all women with incident RA according to the 1987 American College of Rheumatology criteria after inclusion in the health survey were included in a nested... (More)
BACKGROUND: As rheumatoid arthritis (RA) occurs more often in women than in men, it has been suggested that reproductive hormones may play an important role in the pathogenesis.METHODS: Between 1991 and 1996, 30 447 subjects (18 326 women) were included in a community-based health survey. Information on female hormonal changes and stress-related factors was obtained using a self-administered questionnaire. This population was linked to four different local and national RA registers. The medical records for patients with a diagnosis of RA were subjected to a structured review and all women with incident RA according to the 1987 American College of Rheumatology criteria after inclusion in the health survey were included in a nested case-control study. Matched controls (1:4) were selected from the health survey population.RESULTS: Early age at menopause (≤45 years) was associated with the subsequent development of RA (OR 2.42, 95% CI 1.32 to 4.45). The effect of early menopause remained significant after adjusting for smoking, level of education and length of breastfeeding (OR 1.92, 95% CI 1.02 to 3.64)CONCLUSION: RA was predicted by an early age at menopause. This implicates an influence of hormonal changes during the fertile period on the development of RA in postmenopausal women. (Less)
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Contribution to journal
publication status
published
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in
Annals of the Rheumatic Diseases
volume
71
pages
378 - 381
publisher
British Medical Association
external identifiers
  • wos:000300039700012
  • pmid:21972241
  • scopus:84857237793
ISSN
1468-2060
DOI
10.1136/ard.2011.200059
language
English
LU publication?
yes
id
f3eefc3c-a50b-4214-867e-96504a4d2d49 (old id 2200820)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/21972241?dopt=Abstract
date added to LUP
2011-11-02 07:48:00
date last changed
2017-07-23 04:59:14
@article{f3eefc3c-a50b-4214-867e-96504a4d2d49,
  abstract     = {BACKGROUND: As rheumatoid arthritis (RA) occurs more often in women than in men, it has been suggested that reproductive hormones may play an important role in the pathogenesis.METHODS: Between 1991 and 1996, 30 447 subjects (18 326 women) were included in a community-based health survey. Information on female hormonal changes and stress-related factors was obtained using a self-administered questionnaire. This population was linked to four different local and national RA registers. The medical records for patients with a diagnosis of RA were subjected to a structured review and all women with incident RA according to the 1987 American College of Rheumatology criteria after inclusion in the health survey were included in a nested case-control study. Matched controls (1:4) were selected from the health survey population.RESULTS: Early age at menopause (≤45 years) was associated with the subsequent development of RA (OR 2.42, 95% CI 1.32 to 4.45). The effect of early menopause remained significant after adjusting for smoking, level of education and length of breastfeeding (OR 1.92, 95% CI 1.02 to 3.64)CONCLUSION: RA was predicted by an early age at menopause. This implicates an influence of hormonal changes during the fertile period on the development of RA in postmenopausal women.},
  author       = {Pikwer, Mitra and Bergström, Ulf and Nilsson, Jan-Åke and Jacobsson, Lennart and Turesson, Carl},
  issn         = {1468-2060},
  language     = {eng},
  pages        = {378--381},
  publisher    = {British Medical Association},
  series       = {Annals of the Rheumatic Diseases},
  title        = {Early menopause is an independent predictor of rheumatoid arthritis.},
  url          = {http://dx.doi.org/10.1136/ard.2011.200059},
  volume       = {71},
  year         = {2012},
}