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Graft-Induced Dyskinesias in Parkinson's Disease: High Striatal Serotonin/Dopamine Transporter Ratio

Politis, Marios; Oertel, Wolfgang H.; Wu, Kit; Quinn, Niall P.; Pogarell, Oliver; Brooks, David J.; Björklund, Anders LU ; Lindvall, Olle LU and Piccini, Paola (2011) In Movement Disorders 26(11). p.1997-2003
Abstract
Graft-induced dyskinesias are a serious complication after neural transplantation in Parkinson's disease. One patient with Parkinson's disease, treated with fetal grafts 14 years ago and deep brain stimulation 6 years ago, showed marked improvement of motor symptoms but continued to suffer from OFF-medication graft-induced dyskinesias. The patient received a series of clinical and imaging assessments. Positron emission tomography and single-photon emission computed tomography 14 years posttransplantation revealed an elevated serotonin/dopamine transporter ratio in the grafted striatum compatible with serotonergic hyperinnervation. Inhibition of serotonin neuron activity by systemic administration of a 5-HT1A agonist suppressed... (More)
Graft-induced dyskinesias are a serious complication after neural transplantation in Parkinson's disease. One patient with Parkinson's disease, treated with fetal grafts 14 years ago and deep brain stimulation 6 years ago, showed marked improvement of motor symptoms but continued to suffer from OFF-medication graft-induced dyskinesias. The patient received a series of clinical and imaging assessments. Positron emission tomography and single-photon emission computed tomography 14 years posttransplantation revealed an elevated serotonin/dopamine transporter ratio in the grafted striatum compatible with serotonergic hyperinnervation. Inhibition of serotonin neuron activity by systemic administration of a 5-HT1A agonist suppressed graft-induced dyskinesias. Our data provide further evidence that serotonergic neurons mediate graft-induced dyskinesias in Parkinson's disease. Achieving a normal striatal serotonin/dopamine transporter ratio following transplantation of fetal tissue or stem cells should be necessary to avoid the development of graft-induced dyskinesias. (C) 2011 Movement Disorder Society (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Parkinson, transplantation, dyskinesias, serotonin transporter, dopamine transporter
in
Movement Disorders
volume
26
issue
11
pages
1997 - 2003
publisher
John Wiley & Sons
external identifiers
  • wos:000295456300008
  • scopus:80052971467
ISSN
0885-3185
DOI
10.1002/mds.23743
language
English
LU publication?
yes
id
49e357ef-141b-4583-a82a-6fd4c05ae5ad (old id 2211682)
date added to LUP
2011-12-01 08:36:57
date last changed
2017-11-05 03:20:25
@article{49e357ef-141b-4583-a82a-6fd4c05ae5ad,
  abstract     = {Graft-induced dyskinesias are a serious complication after neural transplantation in Parkinson's disease. One patient with Parkinson's disease, treated with fetal grafts 14 years ago and deep brain stimulation 6 years ago, showed marked improvement of motor symptoms but continued to suffer from OFF-medication graft-induced dyskinesias. The patient received a series of clinical and imaging assessments. Positron emission tomography and single-photon emission computed tomography 14 years posttransplantation revealed an elevated serotonin/dopamine transporter ratio in the grafted striatum compatible with serotonergic hyperinnervation. Inhibition of serotonin neuron activity by systemic administration of a 5-HT1A agonist suppressed graft-induced dyskinesias. Our data provide further evidence that serotonergic neurons mediate graft-induced dyskinesias in Parkinson's disease. Achieving a normal striatal serotonin/dopamine transporter ratio following transplantation of fetal tissue or stem cells should be necessary to avoid the development of graft-induced dyskinesias. (C) 2011 Movement Disorder Society},
  author       = {Politis, Marios and Oertel, Wolfgang H. and Wu, Kit and Quinn, Niall P. and Pogarell, Oliver and Brooks, David J. and Björklund, Anders and Lindvall, Olle and Piccini, Paola},
  issn         = {0885-3185},
  keyword      = {Parkinson,transplantation,dyskinesias,serotonin transporter,dopamine transporter},
  language     = {eng},
  number       = {11},
  pages        = {1997--2003},
  publisher    = {John Wiley & Sons},
  series       = {Movement Disorders},
  title        = {Graft-Induced Dyskinesias in Parkinson's Disease: High Striatal Serotonin/Dopamine Transporter Ratio},
  url          = {http://dx.doi.org/10.1002/mds.23743},
  volume       = {26},
  year         = {2011},
}