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Meteorin is a chemokinetic factor in neuroblast migration and promotes stroke-induced striatal neurogenesis.

Wang, Zhaolu LU ; Andrade, Nuno; Torp, Malene; Wattananit, Somsak LU ; Arvidsson, Andreas LU ; Kokaia, Zaal LU ; Jørgensen, Jesper Roland and Lindvall, Olle LU (2012) In Journal of Cerebral Blood Flow and Metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 32. p.387-398
Abstract
Ischemic stroke affecting the adult brain causes increased progenitor proliferation in the subventricular zone (SVZ) and generation of neuroblasts, which migrate into the damaged striatum and differentiate to mature neurons. Meteorin (METRN), a newly discovered neurotrophic factor, is highly expressed in neural progenitor cells and immature neurons during development, suggesting that it may be involved in neurogenesis. Here, we show that METRN promotes migration of neuroblasts from SVZ explants of postnatal rats and stroke-subjected adult rats via a chemokinetic mechanism, and reduces N-methyl-D-asparate-induced apoptotic cell death in SVZ cells in vitro. Stroke induced by middle cerebral artery occlusion upregulates the expression of... (More)
Ischemic stroke affecting the adult brain causes increased progenitor proliferation in the subventricular zone (SVZ) and generation of neuroblasts, which migrate into the damaged striatum and differentiate to mature neurons. Meteorin (METRN), a newly discovered neurotrophic factor, is highly expressed in neural progenitor cells and immature neurons during development, suggesting that it may be involved in neurogenesis. Here, we show that METRN promotes migration of neuroblasts from SVZ explants of postnatal rats and stroke-subjected adult rats via a chemokinetic mechanism, and reduces N-methyl-D-asparate-induced apoptotic cell death in SVZ cells in vitro. Stroke induced by middle cerebral artery occlusion upregulates the expression of endogenous METRN in cells with neuronal phenotype in striatum. Recombinant METRN infused into the stroke-damaged brain stimulates cell proliferation in SVZ, promotes neuroblast migration, and increases the number of immature and mature neurons in the ischemic striatum. Our findings identify METRN as a new factor promoting neurogenesis both in vitro and in vivo by multiple mechanisms. Further work will be needed to translate METRN's actions on endogenous neurogenesis into improved recovery after stroke.Journal of Cerebral Blood Flow & Metabolism advance online publication, 2 November 2011; doi:10.1038/jcbfm.2011.156. (Less)
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published
subject
in
Journal of Cerebral Blood Flow and Metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
volume
32
pages
387 - 398
publisher
Nature Publishing Group
external identifiers
  • WOS:000299857200018
  • PMID:22044868
  • Scopus:84856418869
ISSN
1559-7016
DOI
10.1038/jcbfm.2011.156
language
English
LU publication?
yes
id
2c0709ca-aed1-41b7-bd6a-cd0571417224 (old id 2221288)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/22044868?dopt=Abstract
date added to LUP
2011-12-02 18:29:11
date last changed
2017-01-01 07:53:37
@article{2c0709ca-aed1-41b7-bd6a-cd0571417224,
  abstract     = {Ischemic stroke affecting the adult brain causes increased progenitor proliferation in the subventricular zone (SVZ) and generation of neuroblasts, which migrate into the damaged striatum and differentiate to mature neurons. Meteorin (METRN), a newly discovered neurotrophic factor, is highly expressed in neural progenitor cells and immature neurons during development, suggesting that it may be involved in neurogenesis. Here, we show that METRN promotes migration of neuroblasts from SVZ explants of postnatal rats and stroke-subjected adult rats via a chemokinetic mechanism, and reduces N-methyl-D-asparate-induced apoptotic cell death in SVZ cells in vitro. Stroke induced by middle cerebral artery occlusion upregulates the expression of endogenous METRN in cells with neuronal phenotype in striatum. Recombinant METRN infused into the stroke-damaged brain stimulates cell proliferation in SVZ, promotes neuroblast migration, and increases the number of immature and mature neurons in the ischemic striatum. Our findings identify METRN as a new factor promoting neurogenesis both in vitro and in vivo by multiple mechanisms. Further work will be needed to translate METRN's actions on endogenous neurogenesis into improved recovery after stroke.Journal of Cerebral Blood Flow & Metabolism advance online publication, 2 November 2011; doi:10.1038/jcbfm.2011.156.},
  author       = {Wang, Zhaolu and Andrade, Nuno and Torp, Malene and Wattananit, Somsak and Arvidsson, Andreas and Kokaia, Zaal and Jørgensen, Jesper Roland and Lindvall, Olle},
  issn         = {1559-7016},
  language     = {eng},
  pages        = {387--398},
  publisher    = {Nature Publishing Group},
  series       = {Journal of Cerebral Blood Flow and Metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism},
  title        = {Meteorin is a chemokinetic factor in neuroblast migration and promotes stroke-induced striatal neurogenesis.},
  url          = {http://dx.doi.org/10.1038/jcbfm.2011.156},
  volume       = {32},
  year         = {2012},
}