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Risk of cancer of unknown primary among immigrants to Sweden.

Shu, Xiaochen LU ; Sundquist, Kristina LU ; Sundquist, Jan LU and Hemminki, Kari LU (2012) In European Journal of Cancer Prevention 21(1). p.10-14
Abstract
Incidence of cancer of unknown primary (CUP) varies globally, and environmental factors are suspected to be related to its development. Immigrant studies offer insights into disease etiology, but no studies have been published on CUP. We investigated CUP risk in immigrants to Sweden to search for etiological clues. The nationwide Swedish Family Cancer Database was used to calculate standardized incidence ratios for CUP in the first-generation immigrants compared with native Swedes from 1958 to 2008. A total of 2340 patients with CUP were identified among immigrants during a follow-up of 23 million person-years compared with 30 507 patients with CUP identified in native Swedes who were followed for 260 million person-years, showing an... (More)
Incidence of cancer of unknown primary (CUP) varies globally, and environmental factors are suspected to be related to its development. Immigrant studies offer insights into disease etiology, but no studies have been published on CUP. We investigated CUP risk in immigrants to Sweden to search for etiological clues. The nationwide Swedish Family Cancer Database was used to calculate standardized incidence ratios for CUP in the first-generation immigrants compared with native Swedes from 1958 to 2008. A total of 2340 patients with CUP were identified among immigrants during a follow-up of 23 million person-years compared with 30 507 patients with CUP identified in native Swedes who were followed for 260 million person-years, showing an overall standardized incidence ratio of 0.88 (95% confidence interval: 0.85-0.93). The median age at immigration was 28 years for men and 27 for women. Significantly lower CUP risks, ranging from 0.18 to 0.89, were mainly observed among Finnish, German, and Asian immigrants. The decreased risks tended to be lower for women compared with men. Danes of both sexes had an increased risk. The increased or decreased CUP risks observed in this novel study suggested that early life environmental risk factors or genetic factors influence the development of CUP. The risk patterns were modified by sex. The observed differences may give clues about incidence rates in countries of origin for which incidence data are lacking. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
European Journal of Cancer Prevention
volume
21
issue
1
pages
10 - 14
publisher
Lippincott Williams & Wilkins
external identifiers
  • wos:000298119400002
  • pmid:22044851
  • scopus:82555170297
ISSN
1473-5709
DOI
10.1097/CEJ.0b013e3283498ded
language
English
LU publication?
yes
id
7e450c27-260f-4674-91f0-2c862fd5c5de (old id 2221299)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/22044851?dopt=Abstract
date added to LUP
2011-12-02 18:32:00
date last changed
2017-01-01 07:29:54
@article{7e450c27-260f-4674-91f0-2c862fd5c5de,
  abstract     = {Incidence of cancer of unknown primary (CUP) varies globally, and environmental factors are suspected to be related to its development. Immigrant studies offer insights into disease etiology, but no studies have been published on CUP. We investigated CUP risk in immigrants to Sweden to search for etiological clues. The nationwide Swedish Family Cancer Database was used to calculate standardized incidence ratios for CUP in the first-generation immigrants compared with native Swedes from 1958 to 2008. A total of 2340 patients with CUP were identified among immigrants during a follow-up of 23 million person-years compared with 30 507 patients with CUP identified in native Swedes who were followed for 260 million person-years, showing an overall standardized incidence ratio of 0.88 (95% confidence interval: 0.85-0.93). The median age at immigration was 28 years for men and 27 for women. Significantly lower CUP risks, ranging from 0.18 to 0.89, were mainly observed among Finnish, German, and Asian immigrants. The decreased risks tended to be lower for women compared with men. Danes of both sexes had an increased risk. The increased or decreased CUP risks observed in this novel study suggested that early life environmental risk factors or genetic factors influence the development of CUP. The risk patterns were modified by sex. The observed differences may give clues about incidence rates in countries of origin for which incidence data are lacking.},
  author       = {Shu, Xiaochen and Sundquist, Kristina and Sundquist, Jan and Hemminki, Kari},
  issn         = {1473-5709},
  language     = {eng},
  number       = {1},
  pages        = {10--14},
  publisher    = {Lippincott Williams & Wilkins},
  series       = {European Journal of Cancer Prevention},
  title        = {Risk of cancer of unknown primary among immigrants to Sweden.},
  url          = {http://dx.doi.org/10.1097/CEJ.0b013e3283498ded},
  volume       = {21},
  year         = {2012},
}