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Influence of alpha-ketoglutarate on bone mineral density of the femur in piglets

Kowalik, S; Filip, RS; Sliwa, E; Tatara, MR; Pierzynowski, Stefan LU and Studzinski, T (2005) In Bulletin of the Veterinary Institute in Puławy 49(3). p.343-348
Abstract
The aim of this study was to determine the influence of daily oral administration of alpha-ketoglutarate (AKG) on bone mineral density of the femur and concentration of 17-beta-oestradiol in blood plasma during 70 d of postnatal life in piglets. All the animals were kept under standard rearing conditions. AKG was administered orally from the 1(st) d of life, while the control piglets were treated in the same way and time with physiological saline. The experimental and control groups were assigned to 6 age subgroups: 3, 14, 21, 35, 56 and 70 d of life. The animals from both groups were euthanised, then bone samples were collected and frozen at -25 degrees C until further analyses. Using dual-energy x-ray absorptiometry (DEXA method) bone... (More)
The aim of this study was to determine the influence of daily oral administration of alpha-ketoglutarate (AKG) on bone mineral density of the femur and concentration of 17-beta-oestradiol in blood plasma during 70 d of postnatal life in piglets. All the animals were kept under standard rearing conditions. AKG was administered orally from the 1(st) d of life, while the control piglets were treated in the same way and time with physiological saline. The experimental and control groups were assigned to 6 age subgroups: 3, 14, 21, 35, 56 and 70 d of life. The animals from both groups were euthanised, then bone samples were collected and frozen at -25 degrees C until further analyses. Using dual-energy x-ray absorptiometry (DEXA method) bone mineral density of the femora was estimated. Additionally, 17-beta-oestradiol concentration in blood plasma was assayed using RIA-test. The obtained results indicate positive influence of enteral AKG administration on bone mineral density of the femur in piglets. Moreover, AKG increased the level of 17-beta-oestradiol in blood plasma in post-weaned piglets. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
17-beta-oestradiol, bone mineral density, femur, piglets, alpha-ketoglutarate
in
Bulletin of the Veterinary Institute in Puławy
volume
49
issue
3
pages
343 - 348
publisher
National Veterinary Research Institute
external identifiers
  • wos:000232255300017
  • scopus:27644462120
ISSN
0042-4870
language
English
LU publication?
yes
id
6ba33ce4-2eed-421f-a9dd-6e2b356312f0 (old id 222311)
alternative location
http://www.piwet.pulawy.pl/doc/biuletyn_49-3/17_kowalik.pdf
date added to LUP
2007-08-15 11:47:50
date last changed
2017-01-01 06:43:21
@article{6ba33ce4-2eed-421f-a9dd-6e2b356312f0,
  abstract     = {The aim of this study was to determine the influence of daily oral administration of alpha-ketoglutarate (AKG) on bone mineral density of the femur and concentration of 17-beta-oestradiol in blood plasma during 70 d of postnatal life in piglets. All the animals were kept under standard rearing conditions. AKG was administered orally from the 1(st) d of life, while the control piglets were treated in the same way and time with physiological saline. The experimental and control groups were assigned to 6 age subgroups: 3, 14, 21, 35, 56 and 70 d of life. The animals from both groups were euthanised, then bone samples were collected and frozen at -25 degrees C until further analyses. Using dual-energy x-ray absorptiometry (DEXA method) bone mineral density of the femora was estimated. Additionally, 17-beta-oestradiol concentration in blood plasma was assayed using RIA-test. The obtained results indicate positive influence of enteral AKG administration on bone mineral density of the femur in piglets. Moreover, AKG increased the level of 17-beta-oestradiol in blood plasma in post-weaned piglets.},
  author       = {Kowalik, S and Filip, RS and Sliwa, E and Tatara, MR and Pierzynowski, Stefan and Studzinski, T},
  issn         = {0042-4870},
  keyword      = {17-beta-oestradiol,bone mineral density,femur,piglets,alpha-ketoglutarate},
  language     = {eng},
  number       = {3},
  pages        = {343--348},
  publisher    = {National Veterinary Research Institute},
  series       = {Bulletin of the Veterinary Institute in Puławy},
  title        = {Influence of alpha-ketoglutarate on bone mineral density of the femur in piglets},
  volume       = {49},
  year         = {2005},
}