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Reference values for venous and capillary S100B in children

Åstrand, Ramona LU ; Romner, Bertil LU ; Lanke, Jan LU and Undén, Johan LU (2011) In Clinica Chimica Acta 412(23-24). p.2190-2193
Abstract (Swedish)
Abstract in Undetermined

Background: The current management guidelines for pediatric mild head injury (MHI) liberally recommend computed tomography (CT) and frequent admission. Serum protein S100B, currently used in management of adult head injury, has recently shown potential for reducing unnecessary CT scans after pediatric mild head injury. Capillary sampling in children is commonly used when venous sampling fails or is inappropriate. We present reference values for both venous and capillary samples of protein S100B in children.



Methods: Neurologically healthy children aged 1–16, scheduled for minor surgery requiring general anesthesia, were prospectively included. Samples for S100B were drawn before... (More)
Abstract in Undetermined

Background: The current management guidelines for pediatric mild head injury (MHI) liberally recommend computed tomography (CT) and frequent admission. Serum protein S100B, currently used in management of adult head injury, has recently shown potential for reducing unnecessary CT scans after pediatric mild head injury. Capillary sampling in children is commonly used when venous sampling fails or is inappropriate. We present reference values for both venous and capillary samples of protein S100B in children.



Methods: Neurologically healthy children aged 1–16, scheduled for minor surgery requiring general anesthesia, were prospectively included. Samples for S100B were drawn before (venous) and after (venous and capillary) sedation.



Results: Serum values of 455 children (255 boys, 200 girls) aged 1–14 were computed. S100B was higher in younger children for both venous (r = − 0.32) and capillary samples (r = − 0.28). Reference levels for children aged 1 and 2 were significantly higher than for children aged 3–14 years (venous 0.15 μg/L, capillary 0.37 μg/L). For capillary blood, a gender difference was found in the youngest age groups.



Conclusions: We present reference values for venous and capillary S100B in healthy children. These results can be utilized when considering future studies on pediatric head injury and S100B levels. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Protein S100B, Children, Reference values, Capillary, Head injury
in
Clinica Chimica Acta
volume
412
issue
23-24
pages
2190 - 2193
publisher
Elsevier
external identifiers
  • wos:000296686100028
  • scopus:80053626295
ISSN
0009-8981
DOI
10.1016/j.cca.2011.08.009
language
English
LU publication?
yes
id
4a759ca1-d3cc-48b7-9f29-5235a6737586 (old id 2225044)
alternative location
http://www.sciencedirect.com/science/article/pii/S0009898111004578
date added to LUP
2011-12-19 10:55:08
date last changed
2017-02-26 04:24:53
@article{4a759ca1-d3cc-48b7-9f29-5235a6737586,
  abstract     = {<b>Abstract in Undetermined</b><br/><br>
Background: The current management guidelines for pediatric mild head injury (MHI) liberally recommend computed tomography (CT) and frequent admission. Serum protein S100B, currently used in management of adult head injury, has recently shown potential for reducing unnecessary CT scans after pediatric mild head injury. Capillary sampling in children is commonly used when venous sampling fails or is inappropriate. We present reference values for both venous and capillary samples of protein S100B in children.<br/><br>
<br/><br>
Methods: Neurologically healthy children aged 1–16, scheduled for minor surgery requiring general anesthesia, were prospectively included. Samples for S100B were drawn before (venous) and after (venous and capillary) sedation.<br/><br>
<br/><br>
Results: Serum values of 455 children (255 boys, 200 girls) aged 1–14 were computed. S100B was higher in younger children for both venous (r = − 0.32) and capillary samples (r = − 0.28). Reference levels for children aged 1 and 2 were significantly higher than for children aged 3–14 years (venous 0.15 μg/L, capillary 0.37 μg/L). For capillary blood, a gender difference was found in the youngest age groups.<br/><br>
<br/><br>
Conclusions: We present reference values for venous and capillary S100B in healthy children. These results can be utilized when considering future studies on pediatric head injury and S100B levels.},
  author       = {Åstrand, Ramona and Romner, Bertil and Lanke, Jan and Undén, Johan},
  issn         = {0009-8981},
  keyword      = {Protein S100B,Children,Reference values,Capillary,Head injury},
  language     = {eng},
  number       = {23-24},
  pages        = {2190--2193},
  publisher    = {Elsevier},
  series       = {Clinica Chimica Acta},
  title        = {Reference values for venous and capillary S100B in children},
  url          = {http://dx.doi.org/10.1016/j.cca.2011.08.009},
  volume       = {412},
  year         = {2011},
}