Invasive disease caused by Haemophilus influenzae in Sweden 1997-2009; evidence of increasing incidence and clinical burden of non-type b strains
Resman, Fredrik LU ; Ristovski, Mikael LU ; Ahl, Jonas LU ; Forsgren, Arne LU ; Gilsdorf, J. R. ; Jasir, Aftab LU ; Kaijser, B. ; Kronvall, G. and Riesbeck, Kristian LU
(2011)
In Clinical Microbiology and Infection
17(11).
p.1638-1645
- Abstract
- Introduction of a conjugated vaccine against encapsulated Haemophilus influenzae type b (Hib) has led to a dramatic reduction of invasive Hib disease. However, an increasing incidence of invasive disease by H. influenzae non-type b has recently been reported. Non-type b strains have been suggested to be opportunists in an invasive context, but information on clinical consequences and related medical conditions is scarce. In this retrospective study, all H. influenzae isolates (n = 410) from blood and cerebrospinal fluid in three metropolitan Swedish regions between 1997 and 2009 from a population of approximately 3 million individuals were identified. All available isolates were serotyped by PCR (n = 250). We observed a statistically... (More)
- Introduction of a conjugated vaccine against encapsulated Haemophilus influenzae type b (Hib) has led to a dramatic reduction of invasive Hib disease. However, an increasing incidence of invasive disease by H. influenzae non-type b has recently been reported. Non-type b strains have been suggested to be opportunists in an invasive context, but information on clinical consequences and related medical conditions is scarce. In this retrospective study, all H. influenzae isolates (n = 410) from blood and cerebrospinal fluid in three metropolitan Swedish regions between 1997 and 2009 from a population of approximately 3 million individuals were identified. All available isolates were serotyped by PCR (n = 250). We observed a statistically significant increase in the incidence of invasive H. influenzae disease, ascribed to non-typeable H. influenzae (NTHi) and encapsulated strains type f (Hif) in mainly individuals >60 years of age. The medical reports from a subset of 136 cases of invasive Haemophilus disease revealed that 48% of invasive NTHi cases and 59% of invasive Hif cases, respectively, met the criteria of severe sepsis or septic shock according to the ACCP/SCCM classification of sepsis grading. One-fifth of invasive NTHi cases and more than one-third of invasive Hif cases were admitted to intensive care units. Only 37% of patients with invasive non-type b disease had evidence of immunocompromise, of which conditions related to impaired humoral immunity was the most common. The clinical burden of invasive non-type b H. influenzae disease, measured as days of hospitalization/100 000 individuals at risk and year, increased significantly throughout the study period. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/2254498
- author
- Resman, Fredrik
LU
; Ristovski, Mikael
LU
; Ahl, Jonas
LU
; Forsgren, Arne
LU
; Gilsdorf, J. R.
; Jasir, Aftab
LU
; Kaijser, B.
; Kronvall, G.
and Riesbeck, Kristian
LU
- organization
- publishing date
- 2011
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Haemophilus influenzae, Hib, Hif, invasive disease, meningitis, sepsis
- in
- Clinical Microbiology and Infection
- volume
- 17
- issue
- 11
- pages
- 1638 - 1645
- publisher
- Wiley-Blackwell
- external identifiers
-
- wos:000296916300014
- scopus:79958818465
- pmid:21054663
- pmid:21054663
- ISSN
- 1469-0691
- DOI
- 10.1111/j.1469-0691.2010.03417.x
- language
- English
- LU publication?
- yes
- id
- f336e231-90b0-4103-bbb4-f5c4f52615b0 (old id 2254498)
- date added to LUP
- 2016-04-01 10:40:34
- date last changed
- 2022-05-13 19:09:31
@article{f336e231-90b0-4103-bbb4-f5c4f52615b0,
abstract = {{Introduction of a conjugated vaccine against encapsulated Haemophilus influenzae type b (Hib) has led to a dramatic reduction of invasive Hib disease. However, an increasing incidence of invasive disease by H. influenzae non-type b has recently been reported. Non-type b strains have been suggested to be opportunists in an invasive context, but information on clinical consequences and related medical conditions is scarce. In this retrospective study, all H. influenzae isolates (n = 410) from blood and cerebrospinal fluid in three metropolitan Swedish regions between 1997 and 2009 from a population of approximately 3 million individuals were identified. All available isolates were serotyped by PCR (n = 250). We observed a statistically significant increase in the incidence of invasive H. influenzae disease, ascribed to non-typeable H. influenzae (NTHi) and encapsulated strains type f (Hif) in mainly individuals >60 years of age. The medical reports from a subset of 136 cases of invasive Haemophilus disease revealed that 48% of invasive NTHi cases and 59% of invasive Hif cases, respectively, met the criteria of severe sepsis or septic shock according to the ACCP/SCCM classification of sepsis grading. One-fifth of invasive NTHi cases and more than one-third of invasive Hif cases were admitted to intensive care units. Only 37% of patients with invasive non-type b disease had evidence of immunocompromise, of which conditions related to impaired humoral immunity was the most common. The clinical burden of invasive non-type b H. influenzae disease, measured as days of hospitalization/100 000 individuals at risk and year, increased significantly throughout the study period.}},
author = {{Resman, Fredrik and Ristovski, Mikael and Ahl, Jonas and Forsgren, Arne and Gilsdorf, J. R. and Jasir, Aftab and Kaijser, B. and Kronvall, G. and Riesbeck, Kristian}},
issn = {{1469-0691}},
keywords = {{Haemophilus influenzae; Hib; Hif; invasive disease; meningitis; sepsis}},
language = {{eng}},
number = {{11}},
pages = {{1638--1645}},
publisher = {{Wiley-Blackwell}},
series = {{Clinical Microbiology and Infection}},
title = {{Invasive disease caused by Haemophilus influenzae in Sweden 1997-2009; evidence of increasing incidence and clinical burden of non-type b strains}},
url = {{http://dx.doi.org/10.1111/j.1469-0691.2010.03417.x}},
doi = {{10.1111/j.1469-0691.2010.03417.x}},
volume = {{17}},
year = {{2011}},
}