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Measurements of the Optical-properties of Tissue In Conjunction With Photodynamic Therapy

Nilsson, A. M. K; Berg, R and Andersson-Engels, Stefan LU (1995) In Applied Optics 34(21). p.4609-4619
Abstract
A simple optical dosimeter was used to measure the light intensity in rat liver and muscle in vivo with fibers positioned at different depths to investigate whether the light penetration changed during photodynamic therapy (PDT). The results were then correlated with measurements of the three optical-interaction coefficients mu(s), mu(a), and g for wavelengths in the range 500-800 nm for PDT-treated and nontreated rat liver and muscle tissue in vitro. A distinct increase in the absorption coefficient was seen immediately after treatment, in agreement with the decreasing light intensity observed during the treatment, as measured with the optical dosimeter. The collimated transmittance was measured with a narrow-beam setup, and an optical... (More)
A simple optical dosimeter was used to measure the light intensity in rat liver and muscle in vivo with fibers positioned at different depths to investigate whether the light penetration changed during photodynamic therapy (PDT). The results were then correlated with measurements of the three optical-interaction coefficients mu(s), mu(a), and g for wavelengths in the range 500-800 nm for PDT-treated and nontreated rat liver and muscle tissue in vitro. A distinct increase in the absorption coefficient was seen immediately after treatment, in agreement with the decreasing light intensity observed during the treatment, as measured with the optical dosimeter. The collimated transmittance was measured with a narrow-beam setup, and an optical integrating sphere was used to measure the diffuse reflectance and total transmittance of the samples. The corresponding optical properties were obtained by spline interpolation of Monte Carlo-simulated data. To ensure that the measured values were correct, we performed calibration measurements with suspensions of polystyrene microspheres and ink. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Applied Optics
volume
34
issue
21
pages
4609 - 4619
publisher
OSA
external identifiers
  • scopus:0000948303
ISSN
2155-3165
DOI
10.1364/AO.34.004609
language
English
LU publication?
yes
id
248fe26f-60e6-4273-9b6b-8a5b071d9f02 (old id 2259047)
date added to LUP
2012-02-17 22:44:32
date last changed
2017-01-01 07:40:53
@article{248fe26f-60e6-4273-9b6b-8a5b071d9f02,
  abstract     = {A simple optical dosimeter was used to measure the light intensity in rat liver and muscle in vivo with fibers positioned at different depths to investigate whether the light penetration changed during photodynamic therapy (PDT). The results were then correlated with measurements of the three optical-interaction coefficients mu(s), mu(a), and g for wavelengths in the range 500-800 nm for PDT-treated and nontreated rat liver and muscle tissue in vitro. A distinct increase in the absorption coefficient was seen immediately after treatment, in agreement with the decreasing light intensity observed during the treatment, as measured with the optical dosimeter. The collimated transmittance was measured with a narrow-beam setup, and an optical integrating sphere was used to measure the diffuse reflectance and total transmittance of the samples. The corresponding optical properties were obtained by spline interpolation of Monte Carlo-simulated data. To ensure that the measured values were correct, we performed calibration measurements with suspensions of polystyrene microspheres and ink.},
  author       = {Nilsson, A. M. K and Berg, R and Andersson-Engels, Stefan},
  issn         = {2155-3165},
  language     = {eng},
  number       = {21},
  pages        = {4609--4619},
  publisher    = {OSA},
  series       = {Applied Optics},
  title        = {Measurements of the Optical-properties of Tissue In Conjunction With Photodynamic Therapy},
  url          = {http://dx.doi.org/10.1364/AO.34.004609},
  volume       = {34},
  year         = {1995},
}