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Retinol May Counteract the Negative Effect of Cadmium on Bone

Engstrom, Annette; Hakansson, Helen; Skerfving, Staffan LU ; Biellerup, Per; Lidfeldt, Jonas LU ; Lundh, Thomas; Samsioe, Göran LU ; Vahter, Marie and Akesson, Agneta (2011) In Journal of Nutrition 141(12). p.2198-2203
Abstract
Cadmium and high vitamin A intake are both proposed risk factors for low bone mineral density (BMD), but potential interactions have not been studied. Within the Women's Health in the Lund Area, a population-based study in southern Sweden, we measured retinol in serum among 606 women aged 54-64 y. Data on BMD were measured by DXA at the distal forearm. Parathyroid hormone (PTH), bone alkaline phosphatase (bALP), and osteocalcin in serum and deoxypyridinoline (DPD) and cadmium in urine were available. Associations were evaluated using multivariable-adjusted linear regression analysis. Serum retinol concentrations (median, 1.9; range, 0.97-4.3 mu mol/L) were inversely associated with the bone formation markers bALP and osteocalcin (P <=... (More)
Cadmium and high vitamin A intake are both proposed risk factors for low bone mineral density (BMD), but potential interactions have not been studied. Within the Women's Health in the Lund Area, a population-based study in southern Sweden, we measured retinol in serum among 606 women aged 54-64 y. Data on BMD were measured by DXA at the distal forearm. Parathyroid hormone (PTH), bone alkaline phosphatase (bALP), and osteocalcin in serum and deoxypyridinoline (DPD) and cadmium in urine were available. Associations were evaluated using multivariable-adjusted linear regression analysis. Serum retinol concentrations (median, 1.9; range, 0.97-4.3 mu mol/L) were inversely associated with the bone formation markers bALP and osteocalcin (P <= 0.04) and with PTH (P = 0.07) and tended to be positively associated with BMD (P = 0.08) but not with the bone resorption marker DPD, indicating different effects on bone compared to urinary cadmium (median, 0.66; range, 0.12-3.6 nmol/mmol creatinine). Women with serum retinol less than the median and cadmium greater than the median had lower BMD than those with retinol greater than the median and cadmium less than the median (P = 0.016 among all women and P = 0.010 among never-smokers). Our findings suggest that adequate vitamin A status may counteract the adverse association between cadmium and BMD. J. Nutr. 141: 2198-2203, 2011. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Nutrition
volume
141
issue
12
pages
2198 - 2203
publisher
American Society for Nutrition
external identifiers
  • wos:000297387200016
  • scopus:84855519849
ISSN
1541-6100
DOI
10.3945/jn.111.146944
language
English
LU publication?
yes
id
22658e8c-3e5e-4d15-9772-4c02e641c759 (old id 2272013)
date added to LUP
2012-01-02 09:47:39
date last changed
2017-01-01 03:00:19
@article{22658e8c-3e5e-4d15-9772-4c02e641c759,
  abstract     = {Cadmium and high vitamin A intake are both proposed risk factors for low bone mineral density (BMD), but potential interactions have not been studied. Within the Women's Health in the Lund Area, a population-based study in southern Sweden, we measured retinol in serum among 606 women aged 54-64 y. Data on BMD were measured by DXA at the distal forearm. Parathyroid hormone (PTH), bone alkaline phosphatase (bALP), and osteocalcin in serum and deoxypyridinoline (DPD) and cadmium in urine were available. Associations were evaluated using multivariable-adjusted linear regression analysis. Serum retinol concentrations (median, 1.9; range, 0.97-4.3 mu mol/L) were inversely associated with the bone formation markers bALP and osteocalcin (P &lt;= 0.04) and with PTH (P = 0.07) and tended to be positively associated with BMD (P = 0.08) but not with the bone resorption marker DPD, indicating different effects on bone compared to urinary cadmium (median, 0.66; range, 0.12-3.6 nmol/mmol creatinine). Women with serum retinol less than the median and cadmium greater than the median had lower BMD than those with retinol greater than the median and cadmium less than the median (P = 0.016 among all women and P = 0.010 among never-smokers). Our findings suggest that adequate vitamin A status may counteract the adverse association between cadmium and BMD. J. Nutr. 141: 2198-2203, 2011.},
  author       = {Engstrom, Annette and Hakansson, Helen and Skerfving, Staffan and Biellerup, Per and Lidfeldt, Jonas and Lundh, Thomas and Samsioe, Göran and Vahter, Marie and Akesson, Agneta},
  issn         = {1541-6100},
  language     = {eng},
  number       = {12},
  pages        = {2198--2203},
  publisher    = {American Society for Nutrition},
  series       = {Journal of Nutrition},
  title        = {Retinol May Counteract the Negative Effect of Cadmium on Bone},
  url          = {http://dx.doi.org/10.3945/jn.111.146944},
  volume       = {141},
  year         = {2011},
}