Advanced

Bioorganic synthesis, characterization and antioxidant activity of esters of natural phenolics and α-lipoic acid.

Shanker, Shiva LU ; Grey, Carl LU and Adlercreutz, Patrick LU (2012) In Journal of Biotechnology 157(2). p.344-349
Abstract
Chemo-enzymatic synthesis of six esters of natural phenolics and α-lipoic acid was carried to produce novel compounds with potential bioactivity. The synthetic route was mild, simple, and efficient with satisfactory yields. The synthesized compounds were screened for antioxidant activities. The prepared derivatives exhibited very good antioxidant activities as determined by DPPH radical scavenging assay and inhibition of lipid oxidation in fish oil emulsion system. Among the prepared derivatives, three compounds exhibited radical scavenging activity similar to the reference antioxidants, BHT and alpha-tocopherol in the DPPH radical scavenging assay, where as in fish oil emulsion system, two derivatives showed activity, which was similar to... (More)
Chemo-enzymatic synthesis of six esters of natural phenolics and α-lipoic acid was carried to produce novel compounds with potential bioactivity. The synthetic route was mild, simple, and efficient with satisfactory yields. The synthesized compounds were screened for antioxidant activities. The prepared derivatives exhibited very good antioxidant activities as determined by DPPH radical scavenging assay and inhibition of lipid oxidation in fish oil emulsion system. Among the prepared derivatives, three compounds exhibited radical scavenging activity similar to the reference antioxidants, BHT and alpha-tocopherol in the DPPH radical scavenging assay, where as in fish oil emulsion system, two derivatives showed activity, which was similar to the reference antioxidants. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Lipase, Synthesis, Antioxidant, alpha-Lipoic acid, Phenolics
in
Journal of Biotechnology
volume
157
issue
2
pages
344 - 349
publisher
Elsevier
external identifiers
  • wos:000300075100009
  • pmid:22138637
  • scopus:84855676090
ISSN
1873-4863
DOI
10.1016/j.jbiotec.2011.11.012
language
English
LU publication?
yes
id
0afe2b1b-407a-4603-a7f8-a71e11472497 (old id 2274597)
date added to LUP
2012-01-12 17:25:41
date last changed
2017-01-01 03:33:18
@article{0afe2b1b-407a-4603-a7f8-a71e11472497,
  abstract     = {Chemo-enzymatic synthesis of six esters of natural phenolics and α-lipoic acid was carried to produce novel compounds with potential bioactivity. The synthetic route was mild, simple, and efficient with satisfactory yields. The synthesized compounds were screened for antioxidant activities. The prepared derivatives exhibited very good antioxidant activities as determined by DPPH radical scavenging assay and inhibition of lipid oxidation in fish oil emulsion system. Among the prepared derivatives, three compounds exhibited radical scavenging activity similar to the reference antioxidants, BHT and alpha-tocopherol in the DPPH radical scavenging assay, where as in fish oil emulsion system, two derivatives showed activity, which was similar to the reference antioxidants.},
  author       = {Shanker, Shiva and Grey, Carl and Adlercreutz, Patrick},
  issn         = {1873-4863},
  keyword      = {Lipase,Synthesis,Antioxidant,alpha-Lipoic acid,Phenolics},
  language     = {eng},
  number       = {2},
  pages        = {344--349},
  publisher    = {Elsevier},
  series       = {Journal of Biotechnology},
  title        = {Bioorganic synthesis, characterization and antioxidant activity of esters of natural phenolics and α-lipoic acid.},
  url          = {http://dx.doi.org/10.1016/j.jbiotec.2011.11.012},
  volume       = {157},
  year         = {2012},
}