Changes in the Levels of Neurospecific Proteins and in Behavioral Phenomena in Rats with Hepatic Encephalopathy
(2011) In Neurophysiology 43(3). p.205-208- Abstract
- We showed that, under conditions of experimental chronic hepatitis, excessive increases in the levels of a Ca-binding protein, S-100b, and a neuronal cell adhesion molecule, NCAM, occur in all parts of the brain of Wistar rats. This is accompanied by suppression of locomotor and orientational/research activity of the animals and increase in their stress sensitivity. Treatment by a ketoglutarate and cytoflavin in chronic hepatitis provides a clear neuroprotective effect.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/2291613
- author
- Ushakova, G. A. ; Fomenko, O. Z. and Pierzynowski, Stefan LU
- organization
- publishing date
- 2011
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- hepatic encephalopathy, S-100b, NCAM, behavior
- in
- Neurophysiology
- volume
- 43
- issue
- 3
- pages
- 205 - 208
- publisher
- Springer
- external identifiers
-
- wos:000297624700008
- scopus:83555173286
- ISSN
- 0090-2977
- DOI
- 10.1007/s11062-011-9206-4
- language
- English
- LU publication?
- yes
- id
- b31385fc-b6a9-427e-9038-a9f683589e31 (old id 2291613)
- date added to LUP
- 2016-04-01 14:45:32
- date last changed
- 2022-01-28 02:25:44
@article{b31385fc-b6a9-427e-9038-a9f683589e31, abstract = {{We showed that, under conditions of experimental chronic hepatitis, excessive increases in the levels of a Ca-binding protein, S-100b, and a neuronal cell adhesion molecule, NCAM, occur in all parts of the brain of Wistar rats. This is accompanied by suppression of locomotor and orientational/research activity of the animals and increase in their stress sensitivity. Treatment by a ketoglutarate and cytoflavin in chronic hepatitis provides a clear neuroprotective effect.}}, author = {{Ushakova, G. A. and Fomenko, O. Z. and Pierzynowski, Stefan}}, issn = {{0090-2977}}, keywords = {{hepatic encephalopathy; S-100b; NCAM; behavior}}, language = {{eng}}, number = {{3}}, pages = {{205--208}}, publisher = {{Springer}}, series = {{Neurophysiology}}, title = {{Changes in the Levels of Neurospecific Proteins and in Behavioral Phenomena in Rats with Hepatic Encephalopathy}}, url = {{http://dx.doi.org/10.1007/s11062-011-9206-4}}, doi = {{10.1007/s11062-011-9206-4}}, volume = {{43}}, year = {{2011}}, }