Advanced

Changes in the Levels of Neurospecific Proteins and in Behavioral Phenomena in Rats with Hepatic Encephalopathy

Ushakova, G. A.; Fomenko, O. Z. and Pierzynowski, Stefan LU (2011) In Neurophysiology 43(3). p.205-208
Abstract
We showed that, under conditions of experimental chronic hepatitis, excessive increases in the levels of a Ca-binding protein, S-100b, and a neuronal cell adhesion molecule, NCAM, occur in all parts of the brain of Wistar rats. This is accompanied by suppression of locomotor and orientational/research activity of the animals and increase in their stress sensitivity. Treatment by a ketoglutarate and cytoflavin in chronic hepatitis provides a clear neuroprotective effect.
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
hepatic encephalopathy, S-100b, NCAM, behavior
in
Neurophysiology
volume
43
issue
3
pages
205 - 208
publisher
Springer
external identifiers
  • wos:000297624700008
  • scopus:83555173286
ISSN
0090-2977
DOI
10.1007/s11062-011-9206-4
language
English
LU publication?
yes
id
b31385fc-b6a9-427e-9038-a9f683589e31 (old id 2291613)
date added to LUP
2012-01-11 13:18:33
date last changed
2017-01-01 06:25:14
@article{b31385fc-b6a9-427e-9038-a9f683589e31,
  abstract     = {We showed that, under conditions of experimental chronic hepatitis, excessive increases in the levels of a Ca-binding protein, S-100b, and a neuronal cell adhesion molecule, NCAM, occur in all parts of the brain of Wistar rats. This is accompanied by suppression of locomotor and orientational/research activity of the animals and increase in their stress sensitivity. Treatment by a ketoglutarate and cytoflavin in chronic hepatitis provides a clear neuroprotective effect.},
  author       = {Ushakova, G. A. and Fomenko, O. Z. and Pierzynowski, Stefan},
  issn         = {0090-2977},
  keyword      = {hepatic encephalopathy,S-100b,NCAM,behavior},
  language     = {eng},
  number       = {3},
  pages        = {205--208},
  publisher    = {Springer},
  series       = {Neurophysiology},
  title        = {Changes in the Levels of Neurospecific Proteins and in Behavioral Phenomena in Rats with Hepatic Encephalopathy},
  url          = {http://dx.doi.org/10.1007/s11062-011-9206-4},
  volume       = {43},
  year         = {2011},
}