Porous silicon as a potential electrode material in a nerve repair setting: Tissue reactions.
(2009) In Acta Biomaterialia 5. p.2230-2237- Abstract
- We compared porous silicon (pSi) with smooth Si as chip-implant surfaces in a nerve regeneration setting. Silicon chips can be used for recording neural activity and are potential nerve interface devices. A silicon chip with one smooth and one porous side inserted into a tube was used to bridge a 5 mm defect in rat sciatic nerve. Six or 12 weeks later, new nerve structures surrounded by a perineurium-like capsule had formed on each side of the chip. The number of regenerated nerve fibers did not differ on either side of the chip as shown by immunostaining for neurofilaments. However, the capsule that had formed in contact with the chip was significantly thinner on the porous side than on the smooth side. Cellular protrusions had formed on... (More)
- We compared porous silicon (pSi) with smooth Si as chip-implant surfaces in a nerve regeneration setting. Silicon chips can be used for recording neural activity and are potential nerve interface devices. A silicon chip with one smooth and one porous side inserted into a tube was used to bridge a 5 mm defect in rat sciatic nerve. Six or 12 weeks later, new nerve structures surrounded by a perineurium-like capsule had formed on each side of the chip. The number of regenerated nerve fibers did not differ on either side of the chip as shown by immunostaining for neurofilaments. However, the capsule that had formed in contact with the chip was significantly thinner on the porous side than on the smooth side. Cellular protrusions had formed on the pSi side and the regenerated nerve tissue was found to attach firmly to this surface, while the tissue was hardly attached to the smooth silicon surface. We conclude that a pSi surface, due to its large surface area, diminished inflammatory response and firm adhesion to the tissue, should be a good material for the development of new implantable electronic nerve devices. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1367814
- author
- Johansson, Fredrik LU ; Wallman, Lars LU ; Danielsen, Nils LU ; Schouenborg, Jens LU and Kanje, Martin LU
- organization
- publishing date
- 2009
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Acta Biomaterialia
- volume
- 5
- pages
- 2230 - 2237
- publisher
- Elsevier
- external identifiers
-
- wos:000267307900042
- pmid:19285930
- scopus:67349233067
- pmid:19285930
- ISSN
- 1878-7568
- DOI
- 10.1016/j.actbio.2009.02.010
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Functional Zoology (432112239), Science (000006100), Neural Interfaces (013212003), Neurophysiology (013212004), Biology building (Closed 2011) (011008000)
- id
- 22bbaf96-780b-4a9c-b2bd-9e138ed28150 (old id 1367814)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/19285930?dopt=Abstract
- date added to LUP
- 2016-04-04 07:27:11
- date last changed
- 2022-04-15 19:04:08
@article{22bbaf96-780b-4a9c-b2bd-9e138ed28150,
abstract = {{We compared porous silicon (pSi) with smooth Si as chip-implant surfaces in a nerve regeneration setting. Silicon chips can be used for recording neural activity and are potential nerve interface devices. A silicon chip with one smooth and one porous side inserted into a tube was used to bridge a 5 mm defect in rat sciatic nerve. Six or 12 weeks later, new nerve structures surrounded by a perineurium-like capsule had formed on each side of the chip. The number of regenerated nerve fibers did not differ on either side of the chip as shown by immunostaining for neurofilaments. However, the capsule that had formed in contact with the chip was significantly thinner on the porous side than on the smooth side. Cellular protrusions had formed on the pSi side and the regenerated nerve tissue was found to attach firmly to this surface, while the tissue was hardly attached to the smooth silicon surface. We conclude that a pSi surface, due to its large surface area, diminished inflammatory response and firm adhesion to the tissue, should be a good material for the development of new implantable electronic nerve devices.}},
author = {{Johansson, Fredrik and Wallman, Lars and Danielsen, Nils and Schouenborg, Jens and Kanje, Martin}},
issn = {{1878-7568}},
language = {{eng}},
pages = {{2230--2237}},
publisher = {{Elsevier}},
series = {{Acta Biomaterialia}},
title = {{Porous silicon as a potential electrode material in a nerve repair setting: Tissue reactions.}},
url = {{http://dx.doi.org/10.1016/j.actbio.2009.02.010}},
doi = {{10.1016/j.actbio.2009.02.010}},
volume = {{5}},
year = {{2009}},
}