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Underlying maternal and pregnancy-related conditions account for a substantial proportion of neonatal morbidity in late preterm infants

Bonnevier, Anna LU ; Brodszki, Jana LU ; Björklund, Lars J. LU and Källén, Karin LU (2018) In Acta Paediatrica, International Journal of Paediatrics 107(9). p.1521-1528
Abstract

Aim: We studied the impact of maternal and pregnancy-related conditions and the effect of gestational age itself, on the health of infants born late preterm. Methods: Singletons born in gestational weeks 34 + 0 to 41 + 6 in 1995–2013 in the southern region of Sweden were identified from a perinatal register. We found 14 030 infants born late preterm and 294 814 born at term. A hierarchical system was developed to examine the impact of pregnancy complications. The outcomes studied were as follows: neonatal death, central nervous system (CNS) or respiratory disease, infection, neonatal admission and respiratory support. Odds ratios (OR) and 95% confidence intervals (95% CI) were obtained using logistic regression analyses. Results: Late... (More)

Aim: We studied the impact of maternal and pregnancy-related conditions and the effect of gestational age itself, on the health of infants born late preterm. Methods: Singletons born in gestational weeks 34 + 0 to 41 + 6 in 1995–2013 in the southern region of Sweden were identified from a perinatal register. We found 14 030 infants born late preterm and 294 814 born at term. A hierarchical system was developed to examine the impact of pregnancy complications. The outcomes studied were as follows: neonatal death, central nervous system (CNS) or respiratory disease, infection, neonatal admission and respiratory support. Odds ratios (OR) and 95% confidence intervals (95% CI) were obtained using logistic regression analyses. Results: Late preterm infants were at increased risk for all outcomes compared to term infants, with adjusted ORs from 13.1 (95% CI: 12.7–13.6) for neonatal admission to 2.3 (95% CI: 1.8–2.9) for infections. Late preterm birth after preterm prelabour rupture of membranes was associated with an overall lower risk compared to late preterm births due to other causes. Exposure to antepartum haemorrhage or maternal diabetes increased the risk for CNS and respiratory morbidity. Conclusion: Morbidity decreased in late preterm infants with increasing gestational age. Underlying conditions accounted for a substantial part of the morbidity.

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author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Late preterm birth, Neonatal morbidity, Neonatal mortality, Outcome, Pregnancy complications
in
Acta Paediatrica, International Journal of Paediatrics
volume
107
issue
9
pages
8 pages
publisher
Wiley-Blackwell
external identifiers
  • scopus:85051439585
  • pmid:29575302
ISSN
0803-5253
DOI
10.1111/apa.14321
language
English
LU publication?
yes
id
23109963-3a7c-4043-8dac-9877aaf16c96
date added to LUP
2018-09-07 11:14:16
date last changed
2021-10-06 02:43:36
@article{23109963-3a7c-4043-8dac-9877aaf16c96,
  abstract     = {<p>Aim: We studied the impact of maternal and pregnancy-related conditions and the effect of gestational age itself, on the health of infants born late preterm. Methods: Singletons born in gestational weeks 34 + 0 to 41 + 6 in 1995–2013 in the southern region of Sweden were identified from a perinatal register. We found 14 030 infants born late preterm and 294 814 born at term. A hierarchical system was developed to examine the impact of pregnancy complications. The outcomes studied were as follows: neonatal death, central nervous system (CNS) or respiratory disease, infection, neonatal admission and respiratory support. Odds ratios (OR) and 95% confidence intervals (95% CI) were obtained using logistic regression analyses. Results: Late preterm infants were at increased risk for all outcomes compared to term infants, with adjusted ORs from 13.1 (95% CI: 12.7–13.6) for neonatal admission to 2.3 (95% CI: 1.8–2.9) for infections. Late preterm birth after preterm prelabour rupture of membranes was associated with an overall lower risk compared to late preterm births due to other causes. Exposure to antepartum haemorrhage or maternal diabetes increased the risk for CNS and respiratory morbidity. Conclusion: Morbidity decreased in late preterm infants with increasing gestational age. Underlying conditions accounted for a substantial part of the morbidity.</p>},
  author       = {Bonnevier, Anna and Brodszki, Jana and Björklund, Lars J. and Källén, Karin},
  issn         = {0803-5253},
  language     = {eng},
  month        = {09},
  number       = {9},
  pages        = {1521--1528},
  publisher    = {Wiley-Blackwell},
  series       = {Acta Paediatrica, International Journal of Paediatrics},
  title        = {Underlying maternal and pregnancy-related conditions account for a substantial proportion of neonatal morbidity in late preterm infants},
  url          = {http://dx.doi.org/10.1111/apa.14321},
  doi          = {10.1111/apa.14321},
  volume       = {107},
  year         = {2018},
}