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Age at menarche and the risk of breast cancer in BRCA1 and BRCA2 mutation carriers

Kotsopoulos, J; Lubinski, J; Lynch, H T; Neuhausen, S L; Ghadirian, P; Isaacs, C; Weber, B; Kim-Sing, C; Foulkes, W D and Gershoni-Baruch, R, et al. (2005) In Cancer Causes and Control 16(6). p.667-674
Abstract
Age at menarche is a strong and consistent predictor of breast cancer risk in the general population, but has not been well studied in women with a family history of breast cancer. We conducted this study to examine whether the presence of a deleterious BRCA1 or BRCA2 mutation influences age at menarche and to investigate whether or not there is an association between age at menarche and the risk of breast cancer in BRCA1 or BRCA2 mutation carriers. The presence of a deleterious BRCA1 or BRCA2 mutation did not appear to influence a woman's age at menarche. A matched case-control study was conducted on 1311 pairs of women who have been identified to be carriers of a deleterious mutation in either the BRCA1 (n = 945 pairs) or the BRCA2 gene... (More)
Age at menarche is a strong and consistent predictor of breast cancer risk in the general population, but has not been well studied in women with a family history of breast cancer. We conducted this study to examine whether the presence of a deleterious BRCA1 or BRCA2 mutation influences age at menarche and to investigate whether or not there is an association between age at menarche and the risk of breast cancer in BRCA1 or BRCA2 mutation carriers. The presence of a deleterious BRCA1 or BRCA2 mutation did not appear to influence a woman's age at menarche. A matched case-control study was conducted on 1311 pairs of women who have been identified to be carriers of a deleterious mutation in either the BRCA1 (n = 945 pairs) or the BRCA2 gene (n = 366 pairs). Information about age at menarche was derived from a questionnaire routinely administered to carriers of a mutation in either gene. Among women who carried a deleterious BRCA1 mutation, age at menarche was inversely associated with the risk of breast cancer (p trend = 0.0002). This association was not observed among BRCA2 mutation carriers (p trend = 0.49). Compared with BRCA1 carriers whose age at menarche was <= 11 years, women with a menarcheal age between 14 and 15 years old had a 54% reduction in risk (OR = 0.46; 95% CI 0.30-0.69). This study implicates early age at menarche as a determinant of breast cancer among women with a BRCA1 mutation. (Less)
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published
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keywords
breast cancer, age at menarche, BRCA1, BRCA2, reproductive modifiers, case-control study
in
Cancer Causes and Control
volume
16
issue
6
pages
667 - 674
publisher
Springer
external identifiers
  • wos:000230844600006
  • pmid:16049805
  • scopus:23444448778
ISSN
1573-7225
DOI
10.1007/s10552-005-1724-1
language
English
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yes
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bdc16489-e083-4ae2-9371-9bdc66dad20f (old id 232133)
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2007-08-03 12:04:09
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2017-04-02 03:33:45
@article{bdc16489-e083-4ae2-9371-9bdc66dad20f,
  abstract     = {Age at menarche is a strong and consistent predictor of breast cancer risk in the general population, but has not been well studied in women with a family history of breast cancer. We conducted this study to examine whether the presence of a deleterious BRCA1 or BRCA2 mutation influences age at menarche and to investigate whether or not there is an association between age at menarche and the risk of breast cancer in BRCA1 or BRCA2 mutation carriers. The presence of a deleterious BRCA1 or BRCA2 mutation did not appear to influence a woman's age at menarche. A matched case-control study was conducted on 1311 pairs of women who have been identified to be carriers of a deleterious mutation in either the BRCA1 (n = 945 pairs) or the BRCA2 gene (n = 366 pairs). Information about age at menarche was derived from a questionnaire routinely administered to carriers of a mutation in either gene. Among women who carried a deleterious BRCA1 mutation, age at menarche was inversely associated with the risk of breast cancer (p trend = 0.0002). This association was not observed among BRCA2 mutation carriers (p trend = 0.49). Compared with BRCA1 carriers whose age at menarche was &lt;= 11 years, women with a menarcheal age between 14 and 15 years old had a 54% reduction in risk (OR = 0.46; 95% CI 0.30-0.69). This study implicates early age at menarche as a determinant of breast cancer among women with a BRCA1 mutation.},
  author       = {Kotsopoulos, J and Lubinski, J and Lynch, H T and Neuhausen, S L and Ghadirian, P and Isaacs, C and Weber, B and Kim-Sing, C and Foulkes, W D and Gershoni-Baruch, R and Ainsworth, P and Friedman, E and Daly, M and Garber, J E and Karlan, B and Olopade, O I and Tung, N and Saal, H M and Eisen, A and Osborne, M and Olsson, Håkan and Gilchrist, D and Sun, P and Narod, S A},
  issn         = {1573-7225},
  keyword      = {breast cancer,age at menarche,BRCA1,BRCA2,reproductive modifiers,case-control study},
  language     = {eng},
  number       = {6},
  pages        = {667--674},
  publisher    = {Springer},
  series       = {Cancer Causes and Control},
  title        = {Age at menarche and the risk of breast cancer in BRCA1 and BRCA2 mutation carriers},
  url          = {http://dx.doi.org/10.1007/s10552-005-1724-1},
  volume       = {16},
  year         = {2005},
}