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Effect of lactobacilli on paracellular permeability in the gut.

Ahrné, Siv LU and Johansson Hagslatt, Marie-Louise (2011) In Nutrients 3(1). p.104-117
Abstract
Paracellular permeability is determined by the complex structures of junctions that are located between the epithelial cells. Already in 1996, it was shown that the human probiotic strain Lactobacillus plantarum 299v and the rat-originating strain Lactobacillus reuteri R2LC could reduce this permeability in a methotrexate-induced colitis model in the rat. Subsequently, many animal models and cell culture systems have shown indications that lactobacilli are able to counteract increased paracellular permeability evoked by cytokines, chemicals, infections, or stress. There have been few human studies focusing on the effect of lactobacilli on intestinal paracellular permeability but recently it has been shown that they could influence the... (More)
Paracellular permeability is determined by the complex structures of junctions that are located between the epithelial cells. Already in 1996, it was shown that the human probiotic strain Lactobacillus plantarum 299v and the rat-originating strain Lactobacillus reuteri R2LC could reduce this permeability in a methotrexate-induced colitis model in the rat. Subsequently, many animal models and cell culture systems have shown indications that lactobacilli are able to counteract increased paracellular permeability evoked by cytokines, chemicals, infections, or stress. There have been few human studies focusing on the effect of lactobacilli on intestinal paracellular permeability but recently it has been shown that they could influence the tight junctions. More precisely, short-term administration of L. plantarum WCSF1 to healthy volunteers increased the relocation of occludin and ZO-1 into the tight junction area between duodenal epithelial cells. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Nutrients
volume
3
issue
1
pages
104 - 117
publisher
MDPI AG
external identifiers
  • wos:000298239900006
  • pmid:22254077
  • scopus:79952046775
ISSN
2072-6643
DOI
10.3390/nu3010104
language
English
LU publication?
yes
id
43f769cc-40ad-4366-b9f9-1c5cb2a676e9 (old id 2336252)
date added to LUP
2012-02-07 17:38:55
date last changed
2017-11-05 03:55:41
@article{43f769cc-40ad-4366-b9f9-1c5cb2a676e9,
  abstract     = {Paracellular permeability is determined by the complex structures of junctions that are located between the epithelial cells. Already in 1996, it was shown that the human probiotic strain Lactobacillus plantarum 299v and the rat-originating strain Lactobacillus reuteri R2LC could reduce this permeability in a methotrexate-induced colitis model in the rat. Subsequently, many animal models and cell culture systems have shown indications that lactobacilli are able to counteract increased paracellular permeability evoked by cytokines, chemicals, infections, or stress. There have been few human studies focusing on the effect of lactobacilli on intestinal paracellular permeability but recently it has been shown that they could influence the tight junctions. More precisely, short-term administration of L. plantarum WCSF1 to healthy volunteers increased the relocation of occludin and ZO-1 into the tight junction area between duodenal epithelial cells.},
  author       = {Ahrné, Siv and Johansson Hagslatt, Marie-Louise},
  issn         = {2072-6643},
  language     = {eng},
  number       = {1},
  pages        = {104--117},
  publisher    = {MDPI AG},
  series       = {Nutrients},
  title        = {Effect of lactobacilli on paracellular permeability in the gut.},
  url          = {http://dx.doi.org/10.3390/nu3010104},
  volume       = {3},
  year         = {2011},
}