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Association of polymorphisms in genes encoding hormone receptors ESR1, ESR2 and LHCGR with the risk and clinical features of testicular germ cell cancer.

Brokken, Leon LU ; Giwercman, Yvonne LU ; Rajpert De-Meyts, Ewa; Eberhard, Jakob LU ; Ståhl, Olof LU ; Cohn-Cedermark, Gabriella; Daugaard, Gedske; Arver, Stefan and Giwercman, Aleksander LU (2012) In Molecular and Cellular Endocrinology 351(2). p.279-285
Abstract
Testicular germ cell cancer (TGCC) is the most common malignancy in young men. Genetic variants known to be associated with risk of TGCC only partially account for the observed familial risks. We aimed to identify additional polymorphisms associated with risk as well as histological and clinical features of TGCC in 367 patients and 214 controls. Polymorphisms in ESR2 (rs1256063; OR=0.53, 95% CI: 0.35-0.79) and LHCGR (rs4597581; OR=0.68, 95% CI: 0.51-0.89, and rs4953617; OR=1.88, 95% CI: 1.21-2.94) associated with risk of TGCC. Polymorphisms in ESR1 (rs9397080; OR=1.85, 95% CI: 1.18-2.91) and LHCGR (rs7371084; OR=2.37, 95% CI: 1.26-4.49) associated with risk of seminoma and metastasis, respectively. SNPs in ESR1 (rs9397080) and LHCGR... (More)
Testicular germ cell cancer (TGCC) is the most common malignancy in young men. Genetic variants known to be associated with risk of TGCC only partially account for the observed familial risks. We aimed to identify additional polymorphisms associated with risk as well as histological and clinical features of TGCC in 367 patients and 214 controls. Polymorphisms in ESR2 (rs1256063; OR=0.53, 95% CI: 0.35-0.79) and LHCGR (rs4597581; OR=0.68, 95% CI: 0.51-0.89, and rs4953617; OR=1.88, 95% CI: 1.21-2.94) associated with risk of TGCC. Polymorphisms in ESR1 (rs9397080; OR=1.85, 95% CI: 1.18-2.91) and LHCGR (rs7371084; OR=2.37, 95% CI: 1.26-4.49) associated with risk of seminoma and metastasis, respectively. SNPs in ESR1 (rs9397080) and LHCGR (rs7371084) were predictors of higher LH levels and higher androgen sensitivity index in healthy subjects. The results suggest that polymorphisms in ESR1, ESR2 and LHCGR contribute to the risk of developing TGCC, histological subtype, and risk to metastasis. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Molecular and Cellular Endocrinology
volume
351
issue
2
pages
279 - 285
publisher
Elsevier
external identifiers
  • wos:000301906500015
  • pmid:22245602
  • scopus:84857138660
ISSN
1872-8057
DOI
10.1016/j.mce.2011.12.018
language
English
LU publication?
yes
id
94c7ca68-fd10-4e21-8d7a-55bbc2be3c43 (old id 2336414)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/22245602?dopt=Abstract
date added to LUP
2012-02-01 21:03:39
date last changed
2017-04-16 03:21:53
@article{94c7ca68-fd10-4e21-8d7a-55bbc2be3c43,
  abstract     = {Testicular germ cell cancer (TGCC) is the most common malignancy in young men. Genetic variants known to be associated with risk of TGCC only partially account for the observed familial risks. We aimed to identify additional polymorphisms associated with risk as well as histological and clinical features of TGCC in 367 patients and 214 controls. Polymorphisms in ESR2 (rs1256063; OR=0.53, 95% CI: 0.35-0.79) and LHCGR (rs4597581; OR=0.68, 95% CI: 0.51-0.89, and rs4953617; OR=1.88, 95% CI: 1.21-2.94) associated with risk of TGCC. Polymorphisms in ESR1 (rs9397080; OR=1.85, 95% CI: 1.18-2.91) and LHCGR (rs7371084; OR=2.37, 95% CI: 1.26-4.49) associated with risk of seminoma and metastasis, respectively. SNPs in ESR1 (rs9397080) and LHCGR (rs7371084) were predictors of higher LH levels and higher androgen sensitivity index in healthy subjects. The results suggest that polymorphisms in ESR1, ESR2 and LHCGR contribute to the risk of developing TGCC, histological subtype, and risk to metastasis.},
  author       = {Brokken, Leon and Giwercman, Yvonne and Rajpert De-Meyts, Ewa and Eberhard, Jakob and Ståhl, Olof and Cohn-Cedermark, Gabriella and Daugaard, Gedske and Arver, Stefan and Giwercman, Aleksander},
  issn         = {1872-8057},
  language     = {eng},
  number       = {2},
  pages        = {279--285},
  publisher    = {Elsevier},
  series       = {Molecular and Cellular Endocrinology},
  title        = {Association of polymorphisms in genes encoding hormone receptors ESR1, ESR2 and LHCGR with the risk and clinical features of testicular germ cell cancer.},
  url          = {http://dx.doi.org/10.1016/j.mce.2011.12.018},
  volume       = {351},
  year         = {2012},
}