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Clinical system for interstitial photodynamic therapy with combined on-line dosimetry measurements

Soto Thompson, Marcelo LU ; Johansson, Ann LU ; Johansson, Thomas LU ; Andersson-Engels, Stefan LU ; Svanberg, Sune LU ; Bendsöe, Niels LU and Svanberg, Katarina LU (2005) In Applied Optics 44(19). p.4023-4031
Abstract
A system for interstitial photodynamic therapy with delta-aminolaevulinic acid and multiple optical fibers has been developed. The system enables photodynamic treatment of large embedded tumor volumes and utilizes real-time measurements to allow on-line dosimetry. Important parameters such as light fluence rate, sensitizer fluorescence intensity, and changes in local blood oxygen saturation are measured with the same fibers that deliver the therapeutic light. Data from the first clinical treatments on nodular basal cell carcinomas indicate a major treatment-induced light absorption increase, rapid sensitizer photo-bleaching, and a relatively constant global tissue oxygen saturation level during the treatment.
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Applied Optics
volume
44
issue
19
pages
4023 - 4031
publisher
OSA
external identifiers
  • wos:000230153800020
  • pmid:16004049
  • scopus:22144474393
ISSN
2155-3165
language
English
LU publication?
yes
id
90d40a03-d1b4-4710-b4ed-8b43382d64cd (old id 233989)
alternative location
http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=PubMed&list_uids=16004049&dopt=AbstractPlus
date added to LUP
2007-08-08 09:43:25
date last changed
2017-10-01 03:55:59
@article{90d40a03-d1b4-4710-b4ed-8b43382d64cd,
  abstract     = {A system for interstitial photodynamic therapy with delta-aminolaevulinic acid and multiple optical fibers has been developed. The system enables photodynamic treatment of large embedded tumor volumes and utilizes real-time measurements to allow on-line dosimetry. Important parameters such as light fluence rate, sensitizer fluorescence intensity, and changes in local blood oxygen saturation are measured with the same fibers that deliver the therapeutic light. Data from the first clinical treatments on nodular basal cell carcinomas indicate a major treatment-induced light absorption increase, rapid sensitizer photo-bleaching, and a relatively constant global tissue oxygen saturation level during the treatment.},
  author       = {Soto Thompson, Marcelo and Johansson, Ann and Johansson, Thomas and Andersson-Engels, Stefan and Svanberg, Sune and Bendsöe, Niels and Svanberg, Katarina},
  issn         = {2155-3165},
  language     = {eng},
  number       = {19},
  pages        = {4023--4031},
  publisher    = {OSA},
  series       = {Applied Optics},
  title        = {Clinical system for interstitial photodynamic therapy with combined on-line dosimetry measurements},
  volume       = {44},
  year         = {2005},
}