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Effect of short chain fatty acids infused intraileally on interdigestive exocrine pancreatic secretions in growing pigs

Sileikiene, V; Mosenthin, R; Tafaj, M; Kruszewska, Danuta LU ; Weström, Björn LU ; Mattsson, Inger LU and Pierzynowski, Stefan LU (2005) In Journal of Animal Physiology and Animal Nutrition 89(7-8). p.253-259
Abstract
The effect of intraileally infused short chain fatty acids (SCFA) and saline as control on the exocrine pancreatic secretions during the interdigestive phase was studied using three 8-weeks-old piglets. Pigs were surgically fitted with a pancreatic duct catheter, re-entrant duodenal T-cannula for collection and subsequent return of pancreatic juice, and with an infusion T-cannula at the distal ileum. Saline as control, 5.0 and 10.0 mm butyrate, 7.5 and 15.0 mm propionate and 85.0 and 170.0 mm acetate were infused at 2 ml/kg body weight (BW) for 30 min into the ileum of overnight fasted piglets via ileal T-cannula. The calculated volume of infusates was administrated in five equal bolus at 6 min intervals over a period of 30 min. The... (More)
The effect of intraileally infused short chain fatty acids (SCFA) and saline as control on the exocrine pancreatic secretions during the interdigestive phase was studied using three 8-weeks-old piglets. Pigs were surgically fitted with a pancreatic duct catheter, re-entrant duodenal T-cannula for collection and subsequent return of pancreatic juice, and with an infusion T-cannula at the distal ileum. Saline as control, 5.0 and 10.0 mm butyrate, 7.5 and 15.0 mm propionate and 85.0 and 170.0 mm acetate were infused at 2 ml/kg body weight (BW) for 30 min into the ileum of overnight fasted piglets via ileal T-cannula. The calculated volume of infusates was administrated in five equal bolus at 6 min intervals over a period of 30 min. The pancreatic juice was collected 60 and 30 min before and 30, 60, 90 and 120 min after the start of infusion. The trypsin ( p = 0.07, p > 0.15 respectively) and protein ( p > 0.15, p = 0.05 respectively) outputs immediately decreased after the infusion of acetate at the dose of 85.0 and 170.0 mm, respectively, whereas pancreatic juice outflow ( p > 0.15) was not significantly affected when compared with levels 30 min before infusion. After the infusion of butyrate at the dose of 5.0 mm, trypsin ( p = 0.01) and protein ( p = 0.12) outputs increased immediately whereas pancreatic juice outflow was not affected ( p > 0.15) in comparison with levels 30 min before infusion. No significant differences were observed after infusion of butyrate at the dose of 10 mm for the pancreatic juice outflow, trypsin and protein outputs when compared with the level before infusion, although these values were numerically lower immediately after the infusion. The pancreatic juice outflow increased ( p = 0.03) after the infusion of propionate at the dose of 7.5 mm and decreased ( p = 0.005) immediately after the infusion of propionate at the dose of 15.0 mm when compared with the levels 30 min before the infusions. After the infusion of propionate at the dose of 7.5 or 15.0 mm for the output of protein and trypsin, no significant differences ( p > 0.15) were observed when compared with levels 30 min before infusion. In summary, the intraileal infusion of SCFA at different doses exerts a short-term and moderate effect on the interdigestive exocrine pancreatic secretions in pigs. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Animal Physiology and Animal Nutrition
volume
89
issue
7-8
pages
253 - 259
publisher
Wiley-Blackwell
external identifiers
  • pmid:15972075
  • wos:000230006600003
  • scopus:22244465546
ISSN
0931-2439
DOI
10.1111/j.1439-0396.2005.00511.x
language
English
LU publication?
yes
id
abb9628d-166c-4a2c-8432-11e5fb443724 (old id 235699)
date added to LUP
2007-08-13 09:06:35
date last changed
2017-01-01 07:10:35
@article{abb9628d-166c-4a2c-8432-11e5fb443724,
  abstract     = {The effect of intraileally infused short chain fatty acids (SCFA) and saline as control on the exocrine pancreatic secretions during the interdigestive phase was studied using three 8-weeks-old piglets. Pigs were surgically fitted with a pancreatic duct catheter, re-entrant duodenal T-cannula for collection and subsequent return of pancreatic juice, and with an infusion T-cannula at the distal ileum. Saline as control, 5.0 and 10.0 mm butyrate, 7.5 and 15.0 mm propionate and 85.0 and 170.0 mm acetate were infused at 2 ml/kg body weight (BW) for 30 min into the ileum of overnight fasted piglets via ileal T-cannula. The calculated volume of infusates was administrated in five equal bolus at 6 min intervals over a period of 30 min. The pancreatic juice was collected 60 and 30 min before and 30, 60, 90 and 120 min after the start of infusion. The trypsin ( p = 0.07, p > 0.15 respectively) and protein ( p > 0.15, p = 0.05 respectively) outputs immediately decreased after the infusion of acetate at the dose of 85.0 and 170.0 mm, respectively, whereas pancreatic juice outflow ( p > 0.15) was not significantly affected when compared with levels 30 min before infusion. After the infusion of butyrate at the dose of 5.0 mm, trypsin ( p = 0.01) and protein ( p = 0.12) outputs increased immediately whereas pancreatic juice outflow was not affected ( p > 0.15) in comparison with levels 30 min before infusion. No significant differences were observed after infusion of butyrate at the dose of 10 mm for the pancreatic juice outflow, trypsin and protein outputs when compared with the level before infusion, although these values were numerically lower immediately after the infusion. The pancreatic juice outflow increased ( p = 0.03) after the infusion of propionate at the dose of 7.5 mm and decreased ( p = 0.005) immediately after the infusion of propionate at the dose of 15.0 mm when compared with the levels 30 min before the infusions. After the infusion of propionate at the dose of 7.5 or 15.0 mm for the output of protein and trypsin, no significant differences ( p > 0.15) were observed when compared with levels 30 min before infusion. In summary, the intraileal infusion of SCFA at different doses exerts a short-term and moderate effect on the interdigestive exocrine pancreatic secretions in pigs.},
  author       = {Sileikiene, V and Mosenthin, R and Tafaj, M and Kruszewska, Danuta and Weström, Björn and Mattsson, Inger and Pierzynowski, Stefan},
  issn         = {0931-2439},
  language     = {eng},
  number       = {7-8},
  pages        = {253--259},
  publisher    = {Wiley-Blackwell},
  series       = {Journal of Animal Physiology and Animal Nutrition},
  title        = {Effect of short chain fatty acids infused intraileally on interdigestive exocrine pancreatic secretions in growing pigs},
  url          = {http://dx.doi.org/10.1111/j.1439-0396.2005.00511.x},
  volume       = {89},
  year         = {2005},
}