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Coeliac disease in children: a social epidemiological study in Sweden

Wingren, Carl Johan LU ; Björck, Sara LU ; Lynch, Kristian LU ; Ohlsson, Henrik LU ; Agardh, Daniel LU and Merlo, Juan LU (2012) In Acta Pædiatrica 101(2). p.185-191
Abstract
Aim: Little is known on the possible existence of socioeconomic and geographical differences in early coeliac disease (CD) risk. Therefore, we investigated these aspects in children before age two. Methods: Linking the Swedish Medical Birth Registry to several other national registries, we identified all singletons born in Sweden from 1987 to 1993 (n = 792 401) and followed them until 2 years of age to identify cases of CD. Applying multilevel logistic regression analysis, we investigated the association between socioeconomic position (SEP) and CD in children and also whether a possible geographical variation in CD risk was explained by individual characteristics. Results: Low SEP was associated with CD in boys OR 1.37 (95% CI 1.03-1.82),... (More)
Aim: Little is known on the possible existence of socioeconomic and geographical differences in early coeliac disease (CD) risk. Therefore, we investigated these aspects in children before age two. Methods: Linking the Swedish Medical Birth Registry to several other national registries, we identified all singletons born in Sweden from 1987 to 1993 (n = 792 401) and followed them until 2 years of age to identify cases of CD. Applying multilevel logistic regression analysis, we investigated the association between socioeconomic position (SEP) and CD in children and also whether a possible geographical variation in CD risk was explained by individual characteristics. Results: Low SEP was associated with CD in boys OR 1.37 (95% CI 1.03-1.82), but not in girls OR 0.87 (95% CI 0.68-1.12). We found a considerable geographical variation in disease risk (i.e. intra-municipality correlation approximate to 10%) that was not explained by individual characteristics. Conclusions: Low SEP is associated with CD in boys but not in girls. Also, CD appears to be conditioned by geographical area of residence. While our study represents an innovative contribution to the epidemiology of CD in children, the reasons for the observed geographical and socioeconomic differences could be speculated but are still unknown. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Child, Coeliac disease, Infant, Risk factors, Socioeconomic factors
in
Acta Pædiatrica
volume
101
issue
2
pages
185 - 191
publisher
Wiley-Blackwell Publishing Ltd
external identifiers
  • wos:000298914000024
  • pmid:21824189
  • scopus:84855742755
ISSN
1651-2227
DOI
10.1111/j.1651-2227.2011.02434.x
language
English
LU publication?
yes
id
941032c9-88f9-49d7-9526-1864d182a890 (old id 2358559)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/21824189?dopt=Abstract
date added to LUP
2012-03-01 11:31:43
date last changed
2017-09-03 04:18:02
@article{941032c9-88f9-49d7-9526-1864d182a890,
  abstract     = {Aim: Little is known on the possible existence of socioeconomic and geographical differences in early coeliac disease (CD) risk. Therefore, we investigated these aspects in children before age two. Methods: Linking the Swedish Medical Birth Registry to several other national registries, we identified all singletons born in Sweden from 1987 to 1993 (n = 792 401) and followed them until 2 years of age to identify cases of CD. Applying multilevel logistic regression analysis, we investigated the association between socioeconomic position (SEP) and CD in children and also whether a possible geographical variation in CD risk was explained by individual characteristics. Results: Low SEP was associated with CD in boys OR 1.37 (95% CI 1.03-1.82), but not in girls OR 0.87 (95% CI 0.68-1.12). We found a considerable geographical variation in disease risk (i.e. intra-municipality correlation approximate to 10%) that was not explained by individual characteristics. Conclusions: Low SEP is associated with CD in boys but not in girls. Also, CD appears to be conditioned by geographical area of residence. While our study represents an innovative contribution to the epidemiology of CD in children, the reasons for the observed geographical and socioeconomic differences could be speculated but are still unknown.},
  author       = {Wingren, Carl Johan and Björck, Sara and Lynch, Kristian and Ohlsson, Henrik and Agardh, Daniel and Merlo, Juan},
  issn         = {1651-2227},
  keyword      = {Child,Coeliac disease,Infant,Risk factors,Socioeconomic factors},
  language     = {eng},
  number       = {2},
  pages        = {185--191},
  publisher    = {Wiley-Blackwell Publishing Ltd},
  series       = {Acta Pædiatrica},
  title        = {Coeliac disease in children: a social epidemiological study in Sweden},
  url          = {http://dx.doi.org/10.1111/j.1651-2227.2011.02434.x},
  volume       = {101},
  year         = {2012},
}