Coeliac disease in children: a social epidemiological study in Sweden
Wingren, Carl Johan LU ; Björck, Sara LU ; Lynch, Kristian LU ; Ohlsson, Henrik LU ; Agardh, Daniel LU and Merlo, Juan LU
(2012)
In Acta Pædiatrica
101(2).
p.185-191
- Abstract
- Aim: Little is known on the possible existence of socioeconomic and geographical differences in early coeliac disease (CD) risk. Therefore, we investigated these aspects in children before age two. Methods: Linking the Swedish Medical Birth Registry to several other national registries, we identified all singletons born in Sweden from 1987 to 1993 (n = 792 401) and followed them until 2 years of age to identify cases of CD. Applying multilevel logistic regression analysis, we investigated the association between socioeconomic position (SEP) and CD in children and also whether a possible geographical variation in CD risk was explained by individual characteristics. Results: Low SEP was associated with CD in boys OR 1.37 (95% CI 1.03-1.82),... (More)
- Aim: Little is known on the possible existence of socioeconomic and geographical differences in early coeliac disease (CD) risk. Therefore, we investigated these aspects in children before age two. Methods: Linking the Swedish Medical Birth Registry to several other national registries, we identified all singletons born in Sweden from 1987 to 1993 (n = 792 401) and followed them until 2 years of age to identify cases of CD. Applying multilevel logistic regression analysis, we investigated the association between socioeconomic position (SEP) and CD in children and also whether a possible geographical variation in CD risk was explained by individual characteristics. Results: Low SEP was associated with CD in boys OR 1.37 (95% CI 1.03-1.82), but not in girls OR 0.87 (95% CI 0.68-1.12). We found a considerable geographical variation in disease risk (i.e. intra-municipality correlation approximate to 10%) that was not explained by individual characteristics. Conclusions: Low SEP is associated with CD in boys but not in girls. Also, CD appears to be conditioned by geographical area of residence. While our study represents an innovative contribution to the epidemiology of CD in children, the reasons for the observed geographical and socioeconomic differences could be speculated but are still unknown. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/2358559
- author
- Wingren, Carl Johan
LU
; Björck, Sara
LU
; Lynch, Kristian
LU
; Ohlsson, Henrik
LU
; Agardh, Daniel
LU
and Merlo, Juan
LU
- organization
- publishing date
- 2012
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Child, Coeliac disease, Infant, Risk factors, Socioeconomic factors
- in
- Acta Pædiatrica
- volume
- 101
- issue
- 2
- pages
- 185 - 191
- publisher
- Wiley-Blackwell
- external identifiers
-
- wos:000298914000024
- pmid:21824189
- scopus:84855742755
- pmid:21824189
- ISSN
- 1651-2227
- DOI
- 10.1111/j.1651-2227.2011.02434.x
- language
- English
- LU publication?
- yes
- id
- 941032c9-88f9-49d7-9526-1864d182a890 (old id 2358559)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/21824189?dopt=Abstract
- date added to LUP
- 2016-04-01 14:24:28
- date last changed
- 2022-03-06 19:07:31
@article{941032c9-88f9-49d7-9526-1864d182a890,
abstract = {{Aim: Little is known on the possible existence of socioeconomic and geographical differences in early coeliac disease (CD) risk. Therefore, we investigated these aspects in children before age two. Methods: Linking the Swedish Medical Birth Registry to several other national registries, we identified all singletons born in Sweden from 1987 to 1993 (n = 792 401) and followed them until 2 years of age to identify cases of CD. Applying multilevel logistic regression analysis, we investigated the association between socioeconomic position (SEP) and CD in children and also whether a possible geographical variation in CD risk was explained by individual characteristics. Results: Low SEP was associated with CD in boys OR 1.37 (95% CI 1.03-1.82), but not in girls OR 0.87 (95% CI 0.68-1.12). We found a considerable geographical variation in disease risk (i.e. intra-municipality correlation approximate to 10%) that was not explained by individual characteristics. Conclusions: Low SEP is associated with CD in boys but not in girls. Also, CD appears to be conditioned by geographical area of residence. While our study represents an innovative contribution to the epidemiology of CD in children, the reasons for the observed geographical and socioeconomic differences could be speculated but are still unknown.}},
author = {{Wingren, Carl Johan and Björck, Sara and Lynch, Kristian and Ohlsson, Henrik and Agardh, Daniel and Merlo, Juan}},
issn = {{1651-2227}},
keywords = {{Child; Coeliac disease; Infant; Risk factors; Socioeconomic factors}},
language = {{eng}},
number = {{2}},
pages = {{185--191}},
publisher = {{Wiley-Blackwell}},
series = {{Acta Pædiatrica}},
title = {{Coeliac disease in children: a social epidemiological study in Sweden}},
url = {{http://dx.doi.org/10.1111/j.1651-2227.2011.02434.x}},
doi = {{10.1111/j.1651-2227.2011.02434.x}},
volume = {{101}},
year = {{2012}},
}