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Optimization of PIXE-sensitivity for detection of Ti in thin human skin sections

Pallon, Jan LU ; Garmer, Mats; Auzelyte, Vaida LU ; Elfman, Mikael LU ; Kristiansson, Per LU ; Malmqvist, Klas LU ; Nilsson, Christer LU ; Shariff, Asad LU and Wegdén, Marie LU (2005) In Nuclear Instruments & Methods in Physics Research. Section B: Beam Interactions with Materials and Atoms 231(1-4). p.274-279
Abstract
Modern sunscreens contain particles like TiO2 having sizes of 25-70 nm and acting as a reflecting substance. For cosmetic reasons the particle size is minimized. Questions have been raised to what degree these nano particles penetrate the skin barrier, and how they do affect the human. The EU funded project "Quality of skin as a barrier to ultra-fine particles" - NANODERM has started with the purpose to evaluate the possible risks of TiO2 penetration into vital skin layers. The purpose of the work presented here was to find the optimal conditions for micro-PIXE analysis of Ti in thin skin sections. In the skin region where Ti is expected to be found, the naturally occurring major elements phosphorus, chlorine, sulphur and potassium have... (More)
Modern sunscreens contain particles like TiO2 having sizes of 25-70 nm and acting as a reflecting substance. For cosmetic reasons the particle size is minimized. Questions have been raised to what degree these nano particles penetrate the skin barrier, and how they do affect the human. The EU funded project "Quality of skin as a barrier to ultra-fine particles" - NANODERM has started with the purpose to evaluate the possible risks of TiO2 penetration into vital skin layers. The purpose of the work presented here was to find the optimal conditions for micro-PIXE analysis of Ti in thin skin sections. In the skin region where Ti is expected to be found, the naturally occurring major elements phosphorus, chlorine, sulphur and potassium have steep gradients and thus influence the X-ray background in a non-predictable manner. Based on experimental studies of Ti-exposed human skin sections using proton energies ranging from 1.8-2.55 MeV, the corresponding PIXE detection limits for Ti were calculated. The energy that was found to be the most favourable, 1.9 MeV, was then selected for future studies. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
skin, nuclear microprobe, PIXE, detection limits
in
Nuclear Instruments & Methods in Physics Research. Section B: Beam Interactions with Materials and Atoms
volume
231
issue
1-4
pages
274 - 279
publisher
Elsevier
external identifiers
  • wos:000229752400047
  • scopus:32144445696
ISSN
0168-583X
DOI
10.1016/j.nimb.2005.01.070
language
English
LU publication?
yes
id
bddd91ad-285c-4a5c-9adf-976fb5aa499f (old id 236039)
date added to LUP
2007-08-21 09:01:58
date last changed
2017-01-01 07:05:05
@article{bddd91ad-285c-4a5c-9adf-976fb5aa499f,
  abstract     = {Modern sunscreens contain particles like TiO2 having sizes of 25-70 nm and acting as a reflecting substance. For cosmetic reasons the particle size is minimized. Questions have been raised to what degree these nano particles penetrate the skin barrier, and how they do affect the human. The EU funded project "Quality of skin as a barrier to ultra-fine particles" - NANODERM has started with the purpose to evaluate the possible risks of TiO2 penetration into vital skin layers. The purpose of the work presented here was to find the optimal conditions for micro-PIXE analysis of Ti in thin skin sections. In the skin region where Ti is expected to be found, the naturally occurring major elements phosphorus, chlorine, sulphur and potassium have steep gradients and thus influence the X-ray background in a non-predictable manner. Based on experimental studies of Ti-exposed human skin sections using proton energies ranging from 1.8-2.55 MeV, the corresponding PIXE detection limits for Ti were calculated. The energy that was found to be the most favourable, 1.9 MeV, was then selected for future studies.},
  author       = {Pallon, Jan and Garmer, Mats and Auzelyte, Vaida and Elfman, Mikael and Kristiansson, Per and Malmqvist, Klas and Nilsson, Christer and Shariff, Asad and Wegdén, Marie},
  issn         = {0168-583X},
  keyword      = {skin,nuclear microprobe,PIXE,detection limits},
  language     = {eng},
  number       = {1-4},
  pages        = {274--279},
  publisher    = {Elsevier},
  series       = {Nuclear Instruments & Methods in Physics Research. Section B: Beam Interactions with Materials and Atoms},
  title        = {Optimization of PIXE-sensitivity for detection of Ti in thin human skin sections},
  url          = {http://dx.doi.org/10.1016/j.nimb.2005.01.070},
  volume       = {231},
  year         = {2005},
}