Advanced

Differences in Survival between Patients with Dementia with Lewy Bodies and Patients with Alzheimer's Disease - Measured from a Fixed Cognitive Level.

Stubendorff, Kajsa LU ; Hansson, Oskar LU ; Minthon, Lennart LU and Londos, Elisabet LU (2011) In Dementia and Geriatric Cognitive Disorders 32(6). p.408-416
Abstract
Introduction: The aim of this study was to compare survival in patients with Alzheimer's disease (AD) and patients with dementia with Lewy bodies (DLB). Since anamnestic and retrospective information about disease duration are unreliable variables, we measured survival from a fixed cognitive level. Methods: Survival time was measured from the reported disease onset, from the time of diagnosis, from Mini-Mental State Examination (MMSE) 20 ± 1, and from MMSE 17 ± 1. Results: Survival time was significantly shorter in the DLB group compared to the AD group both from the time of diagnosis and from the cognitive levels of 20 and 17 on the MMSE. There was no difference in survival when measured from the reported disease onset. Discussion: Our... (More)
Introduction: The aim of this study was to compare survival in patients with Alzheimer's disease (AD) and patients with dementia with Lewy bodies (DLB). Since anamnestic and retrospective information about disease duration are unreliable variables, we measured survival from a fixed cognitive level. Methods: Survival time was measured from the reported disease onset, from the time of diagnosis, from Mini-Mental State Examination (MMSE) 20 ± 1, and from MMSE 17 ± 1. Results: Survival time was significantly shorter in the DLB group compared to the AD group both from the time of diagnosis and from the cognitive levels of 20 and 17 on the MMSE. There was no difference in survival when measured from the reported disease onset. Discussion: Our findings indicate that DLB patients have a more malignant clinical course. Our method of investigating survival in a cognitively homogenous population may gain scientific power. Reliable methods to predict survival and the clinical course are of great value for patients, caregivers, doctors, and society. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Dementia and Geriatric Cognitive Disorders
volume
32
issue
6
pages
408 - 416
publisher
Karger
external identifiers
  • wos:000300364500006
  • pmid:22327504
  • scopus:84856805730
ISSN
1420-8008
DOI
10.1159/000335364
language
English
LU publication?
yes
id
6b104443-e071-4c09-9ea2-1159b432525f (old id 2367004)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/22327504?dopt=Abstract
date added to LUP
2012-03-02 11:06:54
date last changed
2017-04-30 15:43:02
@article{6b104443-e071-4c09-9ea2-1159b432525f,
  abstract     = {Introduction: The aim of this study was to compare survival in patients with Alzheimer's disease (AD) and patients with dementia with Lewy bodies (DLB). Since anamnestic and retrospective information about disease duration are unreliable variables, we measured survival from a fixed cognitive level. Methods: Survival time was measured from the reported disease onset, from the time of diagnosis, from Mini-Mental State Examination (MMSE) 20 ± 1, and from MMSE 17 ± 1. Results: Survival time was significantly shorter in the DLB group compared to the AD group both from the time of diagnosis and from the cognitive levels of 20 and 17 on the MMSE. There was no difference in survival when measured from the reported disease onset. Discussion: Our findings indicate that DLB patients have a more malignant clinical course. Our method of investigating survival in a cognitively homogenous population may gain scientific power. Reliable methods to predict survival and the clinical course are of great value for patients, caregivers, doctors, and society.},
  author       = {Stubendorff, Kajsa and Hansson, Oskar and Minthon, Lennart and Londos, Elisabet},
  issn         = {1420-8008},
  language     = {eng},
  number       = {6},
  pages        = {408--416},
  publisher    = {Karger},
  series       = {Dementia and Geriatric Cognitive Disorders},
  title        = {Differences in Survival between Patients with Dementia with Lewy Bodies and Patients with Alzheimer's Disease - Measured from a Fixed Cognitive Level.},
  url          = {http://dx.doi.org/10.1159/000335364},
  volume       = {32},
  year         = {2011},
}