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Impact of maternal characteristics on fetal growth in the third trimester: a population-based study

Lindell, Gun LU ; Marsal, Karel LU and Källén, Karin LU (2012) In Ultrasound in Obsterics and Gynecology 40(6). p.680-687
Abstract
Objectives. To investigate the association between maternal characteristics and fetal growth during the third trimester of pregnancy. Methods. Using a population-based perinatal register, 48,809 term singleton pregnancies were identified for which a routine ultrasound examination in the third trimester was performed between 1995 and 2009. Fetal and infant weight, respectively, were expressed as gestational age specific standard deviation scores (z-scores) using a Swedish ultrasound-based reference curve. The growth of each fetus was assessed using the difference between the birth weight z-score and the fetal weight z-score estimated at the ultrasound examination, adjusted for gestational age, and divided by the time elapsed between the... (More)
Objectives. To investigate the association between maternal characteristics and fetal growth during the third trimester of pregnancy. Methods. Using a population-based perinatal register, 48,809 term singleton pregnancies were identified for which a routine ultrasound examination in the third trimester was performed between 1995 and 2009. Fetal and infant weight, respectively, were expressed as gestational age specific standard deviation scores (z-scores) using a Swedish ultrasound-based reference curve. The growth of each fetus was assessed using the difference between the birth weight z-score and the fetal weight z-score estimated at the ultrasound examination, adjusted for gestational age, and divided by the time elapsed between the ultrasound examination and birth. Analyses were performed using multivariate linear and polynomial regression analyses. Results. Positive associations were found between maternal body mass index (BMI), height, preexisting diabetes mellitus, and a high fetal growth, whereas maternal smoking had a negative impact. In the univariate analyses, primiparity and grand multiparity (≥4 previous children) were significantly associated with a reduced fetal growth, but in the multivariate analysis, no association between parity and fetal growth could be detected. Both the univariate and the multivariate analyses revealed a significant inverse u-shaped association between maternal age and fetal growth. Conclusions. Fetal third trimester growth was positively associated with increasing maternal BMI, height, and pre-existing diabetes mellitus, and was negatively associated with maternal smoking. No significant association between fetal growth and maternal parity or gestational diabetes mellitus was detected when adjustments were made for gestational age and the other maternal characteristics. Copyright © 2012 ISUOG. Published by John Wiley & Sons, Ltd. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
ultrasound, maternal characteristics, intrauterine growth, fetal gender, fetus
in
Ultrasound in Obsterics and Gynecology
volume
40
issue
6
pages
680 - 687
publisher
John Wiley & Sons
external identifiers
  • wos:000311857700013
  • pmid:22302307
  • scopus:84870533794
ISSN
1469-0705
DOI
10.1002/uog.11125
language
English
LU publication?
yes
id
03218367-cbb2-49f8-9399-be7561222635 (old id 2367337)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/22302307?dopt=Abstract
date added to LUP
2012-03-02 08:37:48
date last changed
2017-11-19 04:00:26
@article{03218367-cbb2-49f8-9399-be7561222635,
  abstract     = {Objectives. To investigate the association between maternal characteristics and fetal growth during the third trimester of pregnancy. Methods. Using a population-based perinatal register, 48,809 term singleton pregnancies were identified for which a routine ultrasound examination in the third trimester was performed between 1995 and 2009. Fetal and infant weight, respectively, were expressed as gestational age specific standard deviation scores (z-scores) using a Swedish ultrasound-based reference curve. The growth of each fetus was assessed using the difference between the birth weight z-score and the fetal weight z-score estimated at the ultrasound examination, adjusted for gestational age, and divided by the time elapsed between the ultrasound examination and birth. Analyses were performed using multivariate linear and polynomial regression analyses. Results. Positive associations were found between maternal body mass index (BMI), height, preexisting diabetes mellitus, and a high fetal growth, whereas maternal smoking had a negative impact. In the univariate analyses, primiparity and grand multiparity (≥4 previous children) were significantly associated with a reduced fetal growth, but in the multivariate analysis, no association between parity and fetal growth could be detected. Both the univariate and the multivariate analyses revealed a significant inverse u-shaped association between maternal age and fetal growth. Conclusions. Fetal third trimester growth was positively associated with increasing maternal BMI, height, and pre-existing diabetes mellitus, and was negatively associated with maternal smoking. No significant association between fetal growth and maternal parity or gestational diabetes mellitus was detected when adjustments were made for gestational age and the other maternal characteristics. Copyright © 2012 ISUOG. Published by John Wiley & Sons, Ltd.},
  author       = {Lindell, Gun and Marsal, Karel and Källén, Karin},
  issn         = {1469-0705},
  keyword      = {ultrasound,maternal characteristics,intrauterine growth,fetal gender,fetus},
  language     = {eng},
  number       = {6},
  pages        = {680--687},
  publisher    = {John Wiley & Sons},
  series       = {Ultrasound in Obsterics and Gynecology},
  title        = {Impact of maternal characteristics on fetal growth in the third trimester: a population-based study},
  url          = {http://dx.doi.org/10.1002/uog.11125},
  volume       = {40},
  year         = {2012},
}