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A new automated method for analysis of rCBF-SPECT images based on the active-shape algorithm: normal values.

Hägerström, Douglas LU ; Jakobsson, David; Stomrud, Erik LU ; Andersson, Ann-Margret; Ryding, Erik; Londos, Elisabet LU ; Minthon, Lennart LU ; Rosén, Ingmar LU and Edenbrandt, Lars LU (2012) In Clinical Physiology and Functional Imaging 32(2). p.114-119
Abstract
Most nuclear medicine clinicians use only visual assessment when interpreting regional cerebral blood flow (rCBF) from single-photon emission computed tomography (SPECT) images in clinical practice. The aims of this study were to develop a new, easy to use, automated method for quantification of rCBF-SPECT and to create normal values by using the method on a normal population. We developed a 3-dimensional method based on a brain-shaped model and the active-shape algorithm. The method defines the surface shape of the brain and then projects the maximum counts 0-1·5 cm deep for designated surface points. These surface projection values are divided into cortical regions representing the different lobes and presented relative to the whole... (More)
Most nuclear medicine clinicians use only visual assessment when interpreting regional cerebral blood flow (rCBF) from single-photon emission computed tomography (SPECT) images in clinical practice. The aims of this study were to develop a new, easy to use, automated method for quantification of rCBF-SPECT and to create normal values by using the method on a normal population. We developed a 3-dimensional method based on a brain-shaped model and the active-shape algorithm. The method defines the surface shape of the brain and then projects the maximum counts 0-1·5 cm deep for designated surface points. These surface projection values are divided into cortical regions representing the different lobes and presented relative to the whole cortex, cerebellum or cerebellar maximum. (99m) Tc-hexa methyl propylene amine oxime (HMPAO) SPECT was performed on 30 healthy volunteers with a mean age of 74 years (range 64-98). The ability of the active-shape algorithm to define the shape of the brain was satisfactory when visually scrutinized. The results of the quantification show rCBF values in the frontal, temporal and parietal lobes of 87-88% using cerebellum as the reference. There were no significant differences in normal rCBF values between male and female subjects and only a weak relation between rCBF and age. In conclusion, our new automated method was able to quantify rCBF-SPECT images and create normal values in ranges as expected. Further studies are needed to assess the clinical value of this method and the normal values. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Clinical Physiology and Functional Imaging
volume
32
issue
2
pages
114 - 119
publisher
Wiley Online Library
external identifiers
  • wos:000299734400006
  • pmid:22296631
  • scopus:84856410599
ISSN
1475-0961
DOI
10.1111/j.1475-097X.2011.01063.x
language
English
LU publication?
yes
id
d3f16d1d-2cc6-4df6-9a25-784e9cf9098c (old id 2367452)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/22296631?dopt=Abstract
date added to LUP
2012-03-02 08:19:37
date last changed
2017-01-01 07:34:40
@article{d3f16d1d-2cc6-4df6-9a25-784e9cf9098c,
  abstract     = {Most nuclear medicine clinicians use only visual assessment when interpreting regional cerebral blood flow (rCBF) from single-photon emission computed tomography (SPECT) images in clinical practice. The aims of this study were to develop a new, easy to use, automated method for quantification of rCBF-SPECT and to create normal values by using the method on a normal population. We developed a 3-dimensional method based on a brain-shaped model and the active-shape algorithm. The method defines the surface shape of the brain and then projects the maximum counts 0-1·5 cm deep for designated surface points. These surface projection values are divided into cortical regions representing the different lobes and presented relative to the whole cortex, cerebellum or cerebellar maximum. (99m) Tc-hexa methyl propylene amine oxime (HMPAO) SPECT was performed on 30 healthy volunteers with a mean age of 74 years (range 64-98). The ability of the active-shape algorithm to define the shape of the brain was satisfactory when visually scrutinized. The results of the quantification show rCBF values in the frontal, temporal and parietal lobes of 87-88% using cerebellum as the reference. There were no significant differences in normal rCBF values between male and female subjects and only a weak relation between rCBF and age. In conclusion, our new automated method was able to quantify rCBF-SPECT images and create normal values in ranges as expected. Further studies are needed to assess the clinical value of this method and the normal values.},
  author       = {Hägerström, Douglas and Jakobsson, David and Stomrud, Erik and Andersson, Ann-Margret and Ryding, Erik and Londos, Elisabet and Minthon, Lennart and Rosén, Ingmar and Edenbrandt, Lars},
  issn         = {1475-0961},
  language     = {eng},
  number       = {2},
  pages        = {114--119},
  publisher    = {Wiley Online Library},
  series       = {Clinical Physiology and Functional Imaging},
  title        = {A new automated method for analysis of rCBF-SPECT images based on the active-shape algorithm: normal values.},
  url          = {http://dx.doi.org/10.1111/j.1475-097X.2011.01063.x},
  volume       = {32},
  year         = {2012},
}